No elevation of the frequencies of chromosomal alterations as a consequence of handling cytostatic drugs analyses with peripheral blood and urine of hospital personnel

Stiller, Anna; Obe, G.; Boll, Irene; Pribilla, W

doi:10.1016/0165-7992(83)90211-7

Cited by 40 publications

(14 citation statements)

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“…In some studies, no significant difference in mean number of SCE was found between nurses and controls (Kolmodin-Hedman et al, 1983;Stiller et al, 1983;Barale et al, 1985;Jordan et al, 1986;Stucker et al, 1986). Similar results were obtained in our study.…”

Section: Discussionsupporting

confidence: 94%

“…Similar results have been obtained in 2 other studies (Stiller et al, 1983;Stucker et al, 1986). However, our results must be interpreted with caution.…”

Section: Discussionsupporting

confidence: 92%

“…Conflicting results were obtained: in some studies (Norppa et (Nikula et al, 1984) and an increase in chromosome gap frequency but not in chromosome breaks (Waksvik et al, 1981) were also reported. These last results were not confirmed in 2 other studies (Stiller et al, 1983;Stucker et al, 1986).…”

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confidence: 71%

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Sister chromatid exchanges and chromosomal aberrations in lymphocytes of nurses handling cytostatic agents

Benhamou

Pot-Deprun

Sancho‐Garnier

et al. 1988

Intl Journal of Cancer

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A cohort study of 29 nurses who constantly handled cytostatic drugs, and 29 controls matched according to sex and age, was carried out between 1983 and 1986. Cytogenetic damage was assessed by sister chromatid exchanges (SCE) and chromosomal aberrations. No significant increase in mean number of SCE was found for nurses (7.37) as compared to matched controls (7.00), whereas a significant excess of SCE (p less than 0.001) was observed for smokers (8.23) as compared to non-smokers (6.75). The number of SCE was studied in relation to the amount and nature of cytostatics handled as well as to the duration of exposure. A significant association (p less than 0.05) was found between individual mean number of SCE and the total number of drugs handled after adjustment for confounding factors. In contrast, the number of SCE was not significantly related to the nature of drugs handled or to the duration of exposure. With regard to chromosomal damage, no significant difference was observed between nurses and controls in gap, break, dicentric and translocation frequencies.

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Section: Discussionsupporting

confidence: 94%

“…Similar results have been obtained in 2 other studies (Stiller et al, 1983;Stucker et al, 1986). However, our results must be interpreted with caution.…”

Section: Discussionsupporting

confidence: 92%

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Sister chromatid exchanges and chromosomal aberrations in lymphocytes of nurses handling cytostatic agents

Benhamou

Pot-Deprun

Sancho‐Garnier

et al. 1988

Intl Journal of Cancer

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“…In Hospital 3 nurses, the fluctuation in AC and HFC during the study raises the possibility of genotoxic exposure with cytostatics even when suitable safety cabinets are used, drawing attention to other possible routes of exposure. However, the results in the literature are somewhat contradictory (Stiller et al, 1983;Stucker et al, 1986;Benhamou et al, 1988;Krepinsky et al, 1990;Sarto et al, 1990;Cooke et al, 1991), which can be explained with differences in the working conditions of the referred populations. The discrepancies may also reflect differences in handling, type of drugs handled, and the type and the use of protective equipment (Grummt et al, 1993;Oestreicher et al, 1990).…”

Section: Discussionmentioning

confidence: 70%

“…Negative results were also reported in lymphocyte assays or in bacterial urine mutagenicity assays in nurses (Staiano 308 M. G. JAKAB ET AL. Gibson et al, 1983;Stiller et al, 1983;Barale et al, 1985;Benhamou et al, 1988;Krepinsky et al, 1990). Increased numbers of SCEs, CAs, and gene mutations in lymphocytes of oncology nurses and pharmacists were found (Norppa et al, 1980;Waksvik et al, 1981;Nikula et al, 1984;Chrysostomou et al, 1984;Anwar et al, 1994).…”

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confidence: 91%

Follow-Up Genotoxicological Monitoring of Nurses Handling Antineoplastic Drugs

Jakab

Major

Tompa

2001

Journal of Toxicology and Environmental Health, Part A

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Most of the antineoplastic drugs used in the treatment of tumors are carcinogenic to humans. Hospital nurses are often subject to possible occupational carcinogen exposure. Exposure may occur during handling and administration of infusion solutions containing cytostatics. A genotoxicological monitoring system to detect genotoxic changes was developed in our laboratory, helping to improve working conditions and subserving primary prevention. Multiple-endpoint follow-up genotoxicological monitoring was performed in peripheral blood lymphocytes (PBLs) among 4 groups of 95 nurses (152 investigations) occupationally exposed to cytostatics. The results were compared to those of historical and industrial controls. The genotoxicological endpoints were the determination of the frequency of sister chromatid exchanges (SCEs) and the cells with high-frequency SCEs (HFC), the frequency of structural and numerical chromosome aberrations. and the measurement of ultraviolet-light-induced unscheduled DNA-repair synthesis (UDS). In Hospital 1, where nurses worked without a safety cabinet, the percentage of cells with chromosome aberrations (AC) was significantly higher than that of the controls. In Hospital 2, where nurses used inadequate safety cabinets (with horizontal airflow), significantly elevated levels of AC, SCE, HFC, and UDS were detected. During follow-up, in Hospital 2 at the time of the second investigation AC was still significantly higher, although safety conditions had been improved. The results indicate the presence of genotoxic damage in hospital nurses working with no or inadequate safety equipment. In Hospitals 3 and 4 where nurses using biological safety cabinets, the results were lower than those in the previous two groups. In Hospital 3 in the first year of the study AC was as at the level of industrial controls. During follow-up in the course of the repeated investigations a fluctuation in AC above the control level and an increase in HFC in yr 4 and 6 of the study were observed. In this group, the fluctuation in AC and HFC during the study points to the possibility of genotoxic exposure with cytostatics despite of the use of suitable safety cabinets, drawing attention to other possible routes of exposure. In Hospital 4, both AC and HFC were elevated. These data corroborate the need to maintain safety measures to avoid exposure, and the necessity of intervention in the case of exposure when using and handling hazardous carcinogenic agents. The results also indicate a certain expression time for genotoxic changes, which can lead to late somatic mutations as well as to a possible higher risk of cancer.

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Analysis of sister chromatid exchange and micronuclei in peripheral blood lymphocytes of nurses handling cytostatic drugs

1999

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The genotoxic effect of occupational exposure of 20 nurses who handled cytostatic drugs in medical oncology and haematology units was evaluated by micronucleus and sister chromatide exchange test. The duration of employment in the units and of exposure to cytostatics ranged from 1 to 31 years. The exposed nurses manifested an increase in cells with micronuclei as compared to the control group (P < 0.05). Nurses exposed to cytostatic drugs for 20–31 years showed a higher frequency of micronuclei (P < 0.05), whereas there was no difference in frequencies between the control group and the group exposed for 1–14 years (P > 0.05). The influence of the exposure period proved to be a significant parameter for the micronucleus test. No statistically significant differences were observed in sister chromatid exchange (P > 0.05). Copyright © 1999 John Wiley & Sons, Ltd.

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No elevation of the frequencies of chromosomal alterations as a consequence of handling cytostatic drugs analyses with peripheral blood and urine of hospital personnel

Cited by 40 publications

References 3 publications

Sister chromatid exchanges and chromosomal aberrations in lymphocytes of nurses handling cytostatic agents

Sister chromatid exchanges and chromosomal aberrations in lymphocytes of nurses handling cytostatic agents

Follow-Up Genotoxicological Monitoring of Nurses Handling Antineoplastic Drugs

Analysis of sister chromatid exchange and micronuclei in peripheral blood lymphocytes of nurses handling cytostatic drugs

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