No Evidence of IFN-γ Increase in the Serum of HIV-Positive and Healthy Subjects after Subcutaneous Injection of a Non-Fermented &lt;i&gt;Viscum album&lt;/i&gt; L. Extract

Stoss, Matthias; Gorter, Robert W.

doi:10.1159/000069440

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…However, IFN-g increase in the serum of HIVpositive and healthy subjects was not noticed following subcutaneous injection of a non-fermented V. album extracts. 144 5.10. Anti-mutagenic V. album var.…”

Section: Anti-microbialmentioning

confidence: 99%

European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

et al. 2016

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International audienceViscum album L. or European mistletoe (Loranthaceae), a semi-parasitic shrub, has been used as a traditional medicine in Europe for centuries to treat various diseases like cancer, cardiovascular disorder, epilepsy, infertility, hypertension and arthritis. V. album contains diverse phytochemicals, which exert a large number of biological and pharmacological activities. The aim of this review is to compile the developments in the domain of V. album and research trends, with a focus on ethnopharmacology, phytochemistry and pharmacological properties, to illustrate the potential of this phytotherapeutic as an attractive commercial herbal medicine. Crude extracts and isolated chemical constituents from V. album have exhibited significant medicinal effects in experimental models and in patients with cancer, autoimmune and inflammatory conditions. Importantly, recent randomized clinical trials have suggested improved overall survival and quality of life in cancer patients treated with different mistletoe preparations. The current phytochemical studies have shown that lectins, hetero-dimeric glycoproteins, polysaccharides, viscotoxins, alkaloids, lipids, triterpenes, peptides, vesicles, flavonoids, cyclitols and amines are principal bioactive phytochemicals of V. album. Clinical studies and experimental models have revealed that V. album exhibits several pharmacological functions such as immunomodulatory, anti-hypertensive, anti-oxidant, cytotoxicity, anti-tumor, anti-inflammation, anti-diabetic, anti-microbial and sedative activities. It is conceivable that the heterogenous profile of biochemical compounds provides the basis for the broad diversity of pharmacological activities of mistletoe, as each single component contributes diverse modes of action in addition to imparting a synergistic beneficial action in conjunction with other molecules

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Section: Anti-microbialmentioning

confidence: 99%

European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

et al. 2016

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“…Due to the strong impact of mistletoe on the immune system, it was proposed that it might be useful as a complementary treatment of patients with human immunodeficiency virus (HIV). Studies to confirm the induction of immunomodulation and possibility of the inhibition of the progression of HIV disease are needed (Gorter et al 1996(Gorter et al , 1999Stoss and Gorter 1998;Stoss et al 1999). An in vitro study revealed that a phenolic glycoside, homoeriodictyol-7-O-β-D-glucopyranoside-4′-O-β-D-apiofuranoside, isolated from Viscum articulatum Burm.…”

Section: Antiviral Activitymentioning

confidence: 99%

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

2020

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Boiss. Mistletoe is a semi-parasitic evergreen shrub, which means it depends on having water and some nutrients supplied from another plant (host tree) while it produces carbohydrates in a process of photosynthesis. Viscum species inhabit many types of wooded habitats and parasitize both deciduous and coniferous trees (Bussing 2000). For clinical applications, the most popular species are mistletoe parasitizing fir, maple, almond, birch, hawthorn, ash, apple, pine, poplar, oak, willow, lime and elm (Kienle et al. 2011). Viscum species have been used in the traditional medicine of Europe for centuries. Hippocrates used mistletoe to treat diseases of the spleen and complaints associated with menstruation, while Pliny the Elder used it to treat epilepsy, infertility and ulcers. In the Middle Ages, Paracelsus recommended mistletoe as a treatment for epilepsy. Hildegard von Bingen described mistletoe as a treatment for diseases of the spleen and liver. Mistletoe was also applied for deworming children, to treat labour pains, gout, affections of the lungs and liver, leprosy, mumps, fractures and hepatitis. During the eighteenth century, mistletoe was applied for "weakness of the heart" and oedema (Bussing 2000). By the end of the nineteenth century, mistletoe was rejected by scientists as a folklore remedy. The scientific interest on mistletoe was awakened in the twentieth century, as Gaultier investigated the effect of oral or subcutaneous Abstract Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on membrane receptors, enzymes, ion channels, transporter proteins and transcriptional targets. Still, pharmacological activities of mistletoe have been investigated mainly for crude extracts. It is a new field for scientists to determined which chemical compounds are responsible for the individual biological activities of mistletoe and how these activities are achieved. As a result, mistletoe might become a source of new complementary therapies supporting the treatment of many diseases.

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“…is toxic (Ogunmefun et al 2013). The compounds obtained from V. album are prevalently used for gastro-intestinal, diabetes, blood pressure problems, treatment of cancer, the hepatitis C virus (HCV), HIV, and human parainfluenza virus type 2 (HPIV-2) (Stoss & Gorter 1998, Tusenius et al 2001, Karagöz et al 2003, but the field of the use of the plant may vary based on the chemical properties of host tree which in turn affect compounds present in V. album.…”

Section: Introductionmentioning

confidence: 99%

SCREENING FOR ANTI-QUORUM SENSING AND ANTI-BIOFILM ACTIVITY IN Viscum album L. EXTRACTS AND ITS BIOCHEMICAL COMPOSITION

Erdönmez

Kenar²,

Türkmen³

2018

Trakya University Journal of Natural Sciences

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Many opportunistic pathogenic bacteria use the Quorum Sensing (QS) system to coordinate their virulence expressions. Thus, QS can likely be a new approach to control bacterial infections. The aim of this study was to evaluate the antimicrobial, anti-biofilm, and anti-quorum sensing activities of ethanol, chloroform, and dichloromethane: methanol extracts of leaf, stem, and fruits of the European mistletoe Viscum album L. on 2 Gram-positive and 7 Gram-negative pathogenic bacteria. The extracts at concentrations ranging from 50 to 250mg/ml were tested depending on the extracts of the plant parts and the test bacteria. The extract with 50mg/ml concentration, in which no antimicrobial activity was observed, was used for anti-quorum sensing and antibiofilm studies. The dichloromethane: methanol extracts were found to show the highest biological activities. QS activities of the plant extracts were also determined using the recently established Chromobacterium violaceum CV026 reporter strain and the signaling molecule N-(ß-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL) agar well diffusion assay. Biofilm was quantified using the microtiter plate test and the crystal violet assay. Anti-microbial, anti-biofilm, and anti-quorum sensing activity of leaf and stem extracts showed higher efficiency than fruit extracts. It was concluded that the extracts of V. album had the potential to treat microbial infections by biofilm inhibition or inhibition of QS.

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No Evidence of IFN-γ Increase in the Serum of HIV-Positive and Healthy Subjects after Subcutaneous Injection of a Non-Fermented <i>Viscum album</i> L. Extract

Cited by 4 publications

References 23 publications

European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

SCREENING FOR ANTI-QUORUM SENSING AND ANTI-BIOFILM ACTIVITY IN Viscum album L. EXTRACTS AND ITS BIOCHEMICAL COMPOSITION

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