No Fentanyl Sparing Effect of Intraoperative I.V. Ketorolac After Laparoscopic Tubal Ligation

Green, Carmen R.; Pandit, Sujit K.; Kothary, Sarla P.; Levy, Loren; Mathai, Mary

doi:10.1097/00000542-199209001-00007

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prostaglandins play a significant role in the mediation of post-surgical pain and their inhibition by NSAIDs suggests an attractive supplement to opiate analgesia in this situation 16 . However, while their efficacy in a variety of surgical procedures has been demonstrated [17][18][19] , as discussed above no clear benefit is seen with all laparoscopic procedures, some authors finding them an effective analgesic [1][2][3][4] while others found no benefit [5][6][7][8] . In this group with generally very low pain scores, differences may be hard to distinguish.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Comparison of the Efficacy of Ketorolac and Indomethacin for Postoperative Analgesia following Laparoscopic Surgery in Day Patients

Murrell

Leake

Hughes

1996

Anaesth Intensive Care

View full text Add to dashboard Cite

The analgesia provided in the postoperative period by three regimens commonly used in our private anaesthetic practice were compared in a double-blind study of one hundred and thirty-seven women presenting for day-case laparoscopic procedures. After random allocation into three groups, all patients were similarly anaesthetized and then received both a rectal suppository and an IM injection. Group P received two placebos, Group I had an indomethacin suppository 100 mg, and Group K an IM injection of ketorolac 30 mg. The trial showed a statistically significant reduction in pain at 180 minutes postoperatively in the group receiving ketorolac (visual analog pain score of 13.8 v 21.7). The parenterally administered ketorolac may be a useful analgesic supplement in these patients. However the trial was aborted following the appearance in the literature of case reports of postoperative renal failure. Further investigation of the efficacy and side-effect profile of reduced doses may be warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

“…We noted several regimens in use by our colleagues to achieve the aim of opiatesparing analgesia, and noted that some previous studies in laparoscopic gynaecological surgery have shown benefit from NSAID administration [1][2][3][4] . However other papers show no benefit [5][6][7][8] . This topic was the subject of an extensive review by Souter et al 9 .…”

mentioning

confidence: 97%