No harm from five year ingestion of oats in coeliac disease

Janatuinen, E; Kemppainen, Tarja; Julkunen, Risto; Kosma, Veli‐Matti; Mäki, Markku; Heikkinen, Markku; Uusitupa, Matti

doi:10.1136/gut.50.3.332

Cited by 234 publications

(155 citation statements)

References 17 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…The lack of response to oats in the present study was probably not due to a relatively small amount of the potentially active amino acids in the protein fraction. One can speculate whether the latent time before the symptoms and adverse effects occur is longer on an oat diet than on a gliadin challenge, however Finnish coeliac patients consuming oats have been followed for 5 y without any deterioration (Janatuinen et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adult coeliac patients do tolerate large amounts of oats

et al. 2003

View full text Add to dashboard Cite

Objective: The aim of the present study was to investigate whether adult patients with coeliac disease in remission could include large amounts of oats in their daily gluten-free diet for an extended period of time without adverse effects. Design, subjects and methods: Twenty adult coeliac patients in remission included large amounts of uncontaminated rolled oats in their daily diet for a prolonged period. The examinations, performed four times during the study period, included small bowel endoscopy with biopsies, blood samples (nutritional status, serological analysis), height and body weight, gastrointestinal symptoms and dietary records. Gastrointestinal symptoms and diet were also investigated through unannounced telephone interviews once a month during the study period. Results: No adverse effects of a large intake of oats were seen in small bowel histology, serology nor in nutritional status in the 15 subjects who completed the whole study period. Two of the subjects dropped out because of gastrointestinal symptoms and three for non-medical reasons. The median intake of oats was 93 g=day and the compliance to the oat diet was found to be good. Examinations of the patients after drop-out did not show any deterioration in small bowel histology or nutritional status nor raised levels of antibodies. Conclusion: Results from this study indicate that adult patients with coeliac disease in remission can include large amounts of controlled wheat-free rolled oats for an extended period of time without adverse effects.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Administration of oats to the gluten-free diet has only been studied for short periods of 2 weeks to 6 months, except for the 5 y follow-up of 23 of the participants in the Finnish study (Janatuinen et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Adult coeliac patients do tolerate large amounts of oats

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Proposed nomenclature for food hypersensitivity (1) . Proceedings of the Nutrition Society (93,94) Use of alternative grains should be individualised and based on tolerance as determined by clinician and/or dietitian Proceedings of the Nutrition Society …”

Section: Food Allergymentioning

confidence: 99%

Session 1: Allergic disease The challenges of managing food hypersensitivity

Venter

2009

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Food hypersensitivity (FHS) is the umbrella term used for food allergies that involve the immune system and food intolerances that do not involve the immune system. FHS has a huge impact on quality of life and any dietary advice given should aim to minimise this effect. Despite many advances made in diagnosing and managing patients with FHS, the cornerstone of management still remains avoidance of the relevant food. However, a commonly-presenting dilemma in clinical practice is deciding to what extent the food(s) should be avoided. The level of avoidance required is currently based on the type of FHS the patient has, characteristics of the particular food protein and the natural history of the particular FHS. In addition to management of other FHS, management of cow's milk allergy requires the healthcare professional to choose the appropriate formula. Information required by the patient also includes understanding food labels and issues surrounding cross-contamination. In order to ensure that the diet is nutritionally sound, advice should be given about suitable food choices and following a healthy balanced diet, whilst taking into account the dietary restrictions. Practical issues that need to be addressed include going on holiday, travelling and eating away from home. The dietitian plays a crucial role in this process. At present, there are no standardised documents or protocols for the management of FHS and practices differ within and between countries. If adrenaline auto-injectors are prescribed, correct administration should be demonstrated and reviewed on an ongoing basis. Dietary management: Food allergy: Food intoleranceIn 2004 the European Academy for Allergy and Clinical Immunology and WHO published the revised nomenclature for food hypersensitivity (FHS) as guidance for the management of allergic diseases (1)

show abstract

“…[3] The primary chemical constituents includes saponins (Avenacosides A and B), flavonoids, starch, (trigonelline, avenine, gramine), steroids, calcium, B-vitamins, lysine, methionine and alkaloids such as gramine, they also contain iron, manganese, zinc. [4][5][6] The plant used for depression, exhaustion, stress reduction, nervous system tonic, sexual performance, detoxification, nicotine cravings, fibroids, candidiasis, attention deficit disorder, respiratory and immune support and migraine headaches. [7] There is no significant work has been carried out on the antidepressant effect of this plant extract till date.…”

Section: Introductionmentioning

confidence: 99%

Screening for Antidepressant-Like Effect of Methanolic Seed Extract of Avena Sativa using Animal Models

K¹,

Maddi²,

Nagaphani³

et al. 2014

Phcog J.

View full text Add to dashboard Cite

Depression affects about up to 20% of the population across the globe.The present study was designed to screen antidepressant activity of methanolic seed extract of Avena sativa (MSEAS). An in-vivo experimental methods were designed such as behavioral models like Forced swim test (FST), Tail suspension test (TST) and based on mechanism of action i.e., Antagonism of Apomorphine induced hypothermia on Swiss male albino mice. MSEAS 100 and 200 mg/kg, p.o were administered daily for 7 days. Fluoxetine 25mg/kg p.o was standard antidepressant drug in behavioral models and Desipramine 20mg/kg p.o in Apomorphine induced hypothermia.The methanolic extract produces a significant antidepressant effect in both FST and TST as they reduce the immobility. It was also found, effective in antagonizing or reversing hypothermia produced by apomorphine. The Anti-depressant activity of methanolic seed extract of Avena sativa was found to be significant at low doses (100mg/kg, po). The present study clearly demonstrated that Avena sativa exerts an antidepressant effect in these two behavioral models. The flavonoid components of MSEAS might be interacting with adrenergic system in mediating the anti depressant effect of Avena sativa.

show abstract

No harm from five year ingestion of oats in coeliac disease

Cited by 234 publications

References 17 publications

Adult coeliac patients do tolerate large amounts of oats

Adult coeliac patients do tolerate large amounts of oats

Session 1: Allergic disease The challenges of managing food hypersensitivity

Screening for Antidepressant-Like Effect of Methanolic Seed Extract of Avena Sativa using Animal Models

Contact Info

Product

Resources

About