Screening for Antidepressant-Like Effect of Methanolic Seed Extract of Avena Sativa using Animal Models

K, Usha Rani; Maddi, Ramaiah; Nagaphani, K.; Preethi, V; Srinadh, M

doi:10.5530/pj.2014.3.13

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…The decrease of monoamines, such as that of serotonin, in the brain, is considered to be the main cause of depression [ 103 ]. The plant extract of the mesodermal alkaloid family (Aizoaceae) has the characteristics of serotonin reuptake inhibitor in pharmacology because it contains mesodermal alkaloids.…”

Section: Recent Advances and Successful Examples Of Virtual Screening...mentioning

confidence: 99%

Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases

Zhao

et al. 2023

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The incidence rate of nervous system diseases is increasing in recent years. Nerve injury or neurodegenerative diseases usually cause neuronal loss and neuronal circuit damage, which seriously affect motor nerve and autonomic nervous function. Therefore, a safe and effective treatment is needed. As traditional drug research becomes slower and more expensive, it is vital to enlist the help of cutting-edge technology. Virtual screening (VS) is an attractive option for the identification and development of promising new compounds with high efficiency and low cost. With the assistance of computer-aided drug design (CADD), VS is becoming more and more popular in new drug development and research. In recent years, it has become a reality to transform non-neuronal cells into functional neurons through small molecular compounds, which provides a broader application prospect than transcription factor-mediated neuronal reprogramming. This review mainly summarizes related theory and technology of VS and the drug research and development using VS technology in nervous system diseases in recent years, and focuses more on the potential application of VS technology in neuronal reprogramming, thus facilitating new drug design for both prevention and treatment of nervous system diseases.

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Section: Recent Advances and Successful Examples Of Virtual Screening...mentioning

confidence: 99%

Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases

Zhao

et al. 2023

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Antidepressant potential of Mesembryanthemum cordifolium roots assisted by metabolomic analysis and virtual screening

Said

Ali

Attia

et al. 2020

Natural Product Research

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Depression is a common mental disturbance that can be categorized as mild, moderate or severe. Mesemberine alkaloids, the main recognized phytoconstituents of some plants belonging to family Mesembryanthemaceae, are well-known as serotonin reuptake inhibitors. Therefore, the objective of this study is to evaluate the antidepressant activity of the alkaloidal fraction of Mesembryanthemum cordifolium L.f. (Aptenia cordifolia) roots, family Mesembryanthemaceae using forced swimming test, assisted by metabolomic analysis and in silico ligand-based and structure-based screening. Results showed that the alkaloidal fraction displayed an antidepressant activity superior to imipramine hydrochloride, a standard antidepressant agent. Nine alkaloids were annotated from the metabolomic analysis. Interestingly, among the dereplicated constituents, mesembrane (5) displayed strong binding affinity to SERT protein, which is slightly higher than the antidepressant drug venlafaxine. In conclusion, the alkaloidal fraction of the M. cordifolium (A. cordifolia) root exhibits an antidepressant activity which can be attributed in part to mesembrane (5).

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An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Almost every region of Pakistan is stacked with a large number of medicinal plants. Due to high cost and unavailability of allopathic medicines for the neurological diseases, especially in rural areas, traditional healers prescribe phytotherapy for various neurological diseases like epilepsy, depression, anxiety, insomnia, Alzheimer, and migraine. Such treatments are considered to be most effective by the native people. Methods. The data was collected from articles published on medicinal plants of various districts of Pakistan, using article search engines like Medline, Pubmed, Web of Science, Science Direct, and Google Scholar. Also, information regarding various neurological uses and mode of applications of medicinal plants was obtained from traditional healers, folk medicine users, and local elderly people having knowledge of medicinal plants. Results. A total of 54 families were found to be used in various neurological diseases, of which the highest use was of Solanaceae (22.22%), Asteraceae (12.96%), Lamiaceae, Papaveraceae, and Poaceae, 9% each, and Caprifoliaceae, Cucurbitaceae, Rhamnaceae, and Rosaceae, 5.5% each. According to districts, 15% of plants that were effective in neurological affections were found in Bahawalpur, 11% in Swat, 8% in Muzaffarabad, 7% in Malakand, and 6% in Bahawalnagar, Dir, Gilgat, and Sarghoda each, with 5% in Dera ghazi khan and Jhelum each. According to the plant’s habit, out of total of 103 plants, 61.15% were found to be herbs, 22.33% trees, 11.65% shrubs, and 4.85% climbers. According to the part used of plant, whole plant, leaves, fruits, roots, seeds, and flowers were found to be used 32.03%, 24.27%, 20.38%, 16.50%, 13.59%, and 11.65%, respectively. According to disease’s types, 45.63% were found to be effective in insomnia, 31.06% in epilepsy 12.62% in depression, 6.80% in anxiety, 7.77% in hysteria, and 5.88% in migraine. Conclusion. Taking into consideration this useful knowledge on medicinal properties of the plants for curing neurologic diseases, it is believed that research in areas of ethnomedicine and ethnopharmacology can bring auspicious results that have potential of adding value to the very rich natural resources of Pakistan. This study will help all the researchers from diverse backgrounds working on plants based medicine for neurological diseases.

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Screening for Antidepressant-Like Effect of Methanolic Seed Extract of Avena Sativa using Animal Models

Cited by 4 publications

References 17 publications

Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases

Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases

Antidepressant potential of Mesembryanthemum cordifolium roots assisted by metabolomic analysis and virtual screening

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

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