No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults

Osler, Merete; Andreasen, Anne Helms; Høidrup, Susanne

doi:10.1016/s0895-4356(02)00600-5

Cited by 87 publications

(69 citation statements)

References 18 publications

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“…[1][2][3][4][5] In some studies no such association has been observed, [33][34][35] or an association has been seen for some but not for other cardiovascular outcomes. 36 Based on our English-language Medline search through October 2010, it is apparent that only a few studies have been Figure.…”

Section: Discussionmentioning

confidence: 99%

Fish, n-3 Fatty Acids, and Cardiovascular Diseases in Women of Reproductive Age

Strøm

Halldórsson²,

Mortensen³

et al. 2012

Hypertension

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Abstract-Previous studies have indicated a protective effect of long-chain n-3 polyunsaturated fatty acids (LCn3FAs) against cardiovascular disease; however, women are underrepresented in cardiovascular research. The aim of this study was to explore the association between intake of LCn3FAs and the risk of cardiovascular disease in a large prospective cohort of young women (mean age at baseline: 29.9 years [range: 15.7-46.9] Key Words: cardiovascular diseases Ⅲ fatty acids Ⅲ epidemiology Ⅲ follow-up study Ⅲ women E vidence from observational prospective studies, 1-5 as well as randomized, controlled trials, 6 -8 suggests a protective effect of fish consumption and intake of the essential long-chain n-3 polyunsaturated fatty acids (LCn3FAs) against cardiovascular disease. The hypothesis of a beneficial cardiovascular effect of LCn3FAs originally stems from studies in the Greenland Inuit, where the incidence of coronary heart disease, and, in particular, acute myocardial infarction, was very low. 9 Although findings have not been consistent, 10,11 both previous and recent reviews have concluded that there is solid evidence of a protective effect of LCn3FAs against cardiovascular diseases, 12-16 whereas, on the other hand, a much debated Cochrane review from 2004 concluded that it is unclear whether dietary or supplemental LCn3FAs alter the risk of cardiovascular events in high-risk groups or in the general population. 17 A recent review of the cardiovascular effects of LCn3FAs concluded that, whereas there is evidence of several beneficial cardiovascular effects of LCn3FAs, there are still many uncertainties in the field, for example, regarding arrhythmic events. 18 Recently it has been emphasized by experts that cardiovascular risk in women is underestimated, and women are underrepresented in cardiovascular research. 19,20 Even if most risk factors are shared by men and women, there might be sex differences with regard to their impact, 21 and inflammation, high-density lipoprotein, and triglyceride levels might have a more negative influence on cardiovascular risk in women than in men. 21 Because these risk factors are supposedly affected by LCn3FA intake, this underlines a need for studies on the importance of LCn3FAs in women.The large birth cohorts that have emerged in several countries in the last decade provide information collected on a wide range of exposures and characteristics, which can facilitate such observational studies on etiologic associations in female populations. The aim of this study was to examine

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Section: Discussionmentioning

confidence: 99%

Fish, n-3 Fatty Acids, and Cardiovascular Diseases in Women of Reproductive Age

Strøm

Halldórsson²,

Mortensen³

et al. 2012

Hypertension

View full text Add to dashboard Cite

show abstract

“…98 in the highest quintile). In a Danish study (Osler et al 2003) of 7000 participants the frequency of total fish consumption was found to have no significant effect on CHD mortality or morbidity, with hazard rate ratios of 1 . 09 and 0 .…”

Section: Studies Examining the Health Benefits Of Oily Fish Intakementioning

confidence: 96%

The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype

Anil

2007

Proc. Nutr. Soc.

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Fish and fish oil-rich sources of long-chainn-3 fatty acids have been shown to be cardio-protective, through a multitude of different pathways including effects on arrythymias, endothelial function, inflammation and thrombosis, as well as modulation of both the fasting and postprandial blood lipid profile. To date the majority of studies have examined the impact of EPA and DHA fed simultaneously as fish or fish oil supplements. However, a number of recent studies have compared the relative biopotency of EPAv. DHA in relation to their effect on blood lipid levels. Although many beneficial effects of fish oils have been demonstrated, concern exists about the potential deleterious impact of EPA and DHA on LDL-cholesterol, with a highly-heterogenous response of this lipid fraction reported in the literature. Recent evidence suggests that apoE genotype may be in part responsible. In the present review the impact of EPA and DHA on cardiovascular risk and the blood lipoprotein profile will be considered, with a focus on the apoE gene locus as a possible determinant of lipid responsiveness to fish oil intervention.

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“…Data on fish and all-causes mortality from population-based cohorts are inconsistent and vary from 0% to 30%. [55][56][57][58][59][60] Null findings in some of the studies can possibly be explained by the adverse effects of the high mercury content of fish in some geographic areas 56,61 or by the fact that the protective effect is specific for fatty fish and not for total fish consumption. 62 The association with CAD mortality is more frequently studied than allcauses mortality, and significant risk reductions are reported.…”

Section: Regular Fish (Oil) Consumptionmentioning

confidence: 99%

Effect Size Estimates of Lifestyle and Dietary Changes on All-Cause Mortality in Coronary Artery Disease Patients

et al. 2005

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Background-Guidelines for lifestyle and dietary modification in patients with coronary artery disease (CAD) are mainly supported by evidence from general population studies. CAD patients, however, differ from the general population in age (older) and treatment with preventive drugs. This review seeks to provide evidence for a prognostic benefit of lifestyle and dietary recommendations from studies in CAD patients. Methods and Results-A literature search was performed on the effect of lifestyle and dietary changes on mortality in CAD patients. Prospective cohort studies and randomized controlled trials of patients with established CAD were included if they reported all-causes mortality and had at least 6 months of follow-up.

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No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults

Cited by 87 publications

References 18 publications

Fish, n-3 Fatty Acids, and Cardiovascular Diseases in Women of Reproductive Age

Fish, n-3 Fatty Acids, and Cardiovascular Diseases in Women of Reproductive Age

The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype

Effect Size Estimates of Lifestyle and Dietary Changes on All-Cause Mortality in Coronary Artery Disease Patients

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