No lymphokines in T-cells around loosened hip prostheses

Li, Tian-Fang; Santavirta, Seppo; Waris, Ville; Lassus, Jan; Lindroos, Lauri; Xu, Jingwen; Virtanen, Ismo; Konttinen, Yrjö T.

doi:10.1080/00016470152846556

Cited by 32 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results from these studies indicate that the T cells do not respond in a classical manner, suggesting they have no role in periprosthetic osteolysis. This could depend on a lack of antigen presenting, induction of tolerance over time or production of inhibitory molecules by other inflammatory cells at the implant site [9,11].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with osteolysis caused by bone metastases, we previously described spontaneous osteoclastogenesis, which is due to patients' peripheral blood mononuclear cells (PBMCs) capability to differentiate into OCs in vitro, without adding exogenous factors. Spontaneous osteoclastogenesis depends on T cells, which support and promote OC differentiation and activation [7] The histological analysis of periprosthetic tissues, harvested at revision surgery from patients with aseptic loosening, showed contradictory results about the presence and the role of T cells: some studies documented activated T cells [8,9], others described non-active T cells [10,11] and seldom specific T cells activated by debris were observed [12,13]. New findings in osteoimmunology may provide a different perspective for periprosthetic osteolysis.…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues

Roato¹,

Caldo

D’Amico³

et al. 2010

Biomaterials

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues

Roato¹,

Caldo

D’Amico³

et al. 2010

Biomaterials

View full text Add to dashboard Cite

“…The proliferation of T lymphocytes and their maintenance is dependent on IL-2 in vitro and in vivo, so that a failure to find IL-2 in the implant interface could be taken as meaning those lymphocytes that are present cannot be involved in any immunological process. Indeed, a Finnish group suggested this, having found that T cell numbers were low and that there was no evidence of T cell activation as judged by a lack of IL-2, IFN-g and TNF-b production by these cells and an absence of interleukin-2 receptor (IL-2R) expression (Li et al 2001). As has already been mentioned above, there is evidence of IL-2, IFN-g and TNF-b production when PCR methods are used.…”

Section: The Activation and Proliferation Of T Lymphocytesmentioning

confidence: 99%

The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses

Revell

2008

J. R. Soc. Interface.

179

120

View full text Add to dashboard Cite

This review considers the causes of loosening of prosthetic joint replacement paying attention to the biological mechanisms rather than other effects that are physical, such as component fracture and other failure related to mechanical problems. Infection accounts for approximately 1.5 per cent of joint loosening and when it occurs it is a cause of serious concern to the surgeon. The loosening of prosthetic joints in the absence of infection is by far the most common reason for revision surgery and is known as aseptic loosening. While this may be multifactorial in terms of causation, and non-biological factors may contribute significantly in a particular individual, a significant part is undoubtedly played by the generation of wear debris, mainly from the bearing surfaces of the joint, and the cellular reaction to this in the implant bed. Phagocytic cells (macrophages and multinucleated giant cells) are the ones that remove foreign material from the tissues, and the ways in which these cells function in the interface between implant and bone are described. Mediators produced locally include numerous cytokines, enzymes and integrins. There is evidence for interactions between macrophages and locally recruited lymphocytes, which may or may not give rise to an immunologically mediated process.Sensitization of individuals having metal implants in place has been shown by positive skin tests or blood lymphocyte transformation tests and in these cases has been accompanied by loosening and failure of the replacement joint. The question remains as to whether this process is also present in a proportion of individuals with aseptic loosening in the absence of clearly defined clinical evidence of sensitization.Numerous studies performed by the author's group and, latterly, by others suggest that the cellular reactions detected in the tissues in cases of aseptic loosening are indeed those of contact sensitization. There is good evidence to show that a type IV cell-mediated immune reaction is taking place, with T H 1 cell involvement and active antigen presentation. The extent to which sensitization is present in individual cases of aseptic loosening remains a subject for further work and this needs all the sophisticated molecular methods now available to modern biology to be applied in appropriate prospective clinical studies coupled with experimental models in vitro and in vivo. Immunological processes may play a more important part in joint loosening than previously considered.

show abstract

“…[13][14][15] Analysis of the tissues retrieved during revision THR has given contradictory results. Some authors have found a low number of quiescent lymphocytes, 16 while others have found a correlation between the number of T-lymphocytes and macrophages and the cytokine profile and the clinical and radiological grade of loosening. 17 Most of these studies were carried out on patients with aseptic loosening and it is not yet certain whether the immunological alterations are either involved in the failure of the implant, or related to the presence of the implant or the underlying pathology.…”

mentioning

confidence: 99%

Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement

Granchi

Savarino

Ciapetti

et al. 2003

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

e aimed to assess whether the immunological abnormalities which have been observed in patients with loose total hip replacements (THRs) are present in patients with a well-fixed prosthesis.We examined blood samples from 39 healthy donors, 22 patients before THR and 41 with well-fixed THRs of different types (15 metal-on-metal, 13 metal-onpolyethylene, 13 ceramic-on-ceramic). Before THR, the patients showed a decrease in leukocytes and myeloid cells in comparison with healthy donors, and a prevalence of type-1 T lymphocytes, which was confirmed by the increase in ratio of interferon-γ γ γ γ to interleukin 4. Moreover, patients with metal-on-metal or metal-on-polyethylene implants showed a significant decrease in the number of T lymphocytes and a significant increase in the serum level of chromium and cobalt, although no significant correlation was observed with the immunological changes. In the ceramic-onceramic group, leukocytes and lymphocyte subsets were not significantly changed, but a significant increase in type-2 cytokines restored the ratio of interferon-γ γ γ γ to interleukin 4 to normal values.We conclude that abnormalities of the cell-mediated immune response may be present in patients with a wellfixed THR, and that the immunological changes are more evident in those who have at least one metal component in the articular coupling.J Bone Joint Surg [Br] 2003;85-B:758-64.

show abstract

No lymphokines in T-cells around loosened hip prostheses

Cited by 32 publications

References 23 publications

Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues

Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues

The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses

Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement

Contact Info

Product

Resources

About