No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes

Bizzarri, Carla; Pitocco, Dario; Napoli, Nicola; Stasio, Enrico Di; Maggi, Daria; Manfrini, Silvia; Suraci, C; Cavallo, Maria Gisella; Cappa, Marco; Ghirlanda, Giovanni; Pozzilli, Paolo

doi:10.2337/dc10-0814

Cited by 139 publications

(104 citation statements)

References 7 publications

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“…Research in Germany and Italy also obtained similar results [31,32]. This is due to the duration of disease in this study subjects averaged still a decade so obtained low levels of C-peptide despite the increase of 25(OH)D 3 and this indicates that the progressive destruction of pancreatic β cells occur mainly in the first years of the emergence T1DM disease [38].…”

Section: Subject Characteristicssupporting

confidence: 71%

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Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Section: Subject Characteristicssupporting

confidence: 71%

“…In another study, 34 patients were newly diagnosed with T1DM in a double-blind trial with calcitriol 0.25 µg/day or placebo and followed for 2 years. The levels of C-peptide fell significantly, but in both groups had similar levels, with no significant difference [32].…”

Section: Subject Characteristicsmentioning

confidence: 94%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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“…In a clinical setting, two recent trials found no significant effect of 1,25(OH) 2 D on the preservation of β-cell function after type 1 diabetes onset (58,59). Nevertheless, the dose and mechanistic action of vitamin D are still under discussion.…”

Section: Vitamin D and Type 1 Diabetes Mellitusmentioning

confidence: 99%

Vitamin D and diabetes mellitus: an update 2013

Griz

Bandeira

Gabbay

et al. 2014

Arq Bras Endocrinol Metab

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Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH) 2 D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases. RESUMOA deficiência de vitamina D e o diabetes melito são enfermidades comuns na população e são altamente prevalentes em todas as raças, idades, regiões geográficas e situação socioeconômica. Estudos epidemiológicos mostram uma associação entre hipovitaminose D com o aumento do risco de doenças crônicas, tais como câncer, doença cardiovascular, diabetes melito do tipo 2 e doenças autoimunes como a esclerose múltipla e o diabetes mellitus do tipo 1. A identificação de receptores da 1,25(OH) 2 D e da expressão da 1 α-hidroxilase nas células betapancreáticas, em células do sistema imunológico e em uma variedade de células do organismo além do tecido ósseo, suporta o papel da vitamina D na patogênese do diabetes tipo 2 e do tipo 1. Esta revisão apresenta e discute o conceito de deficiência de vitamina D, sua prevalência e seu papel na patogênese e no risco de desenvolvimento do diabetes melito e doenças cardiovasculares. Arq Bras Endocrinol Metab. 2014;58(1):1-8 Descritores Vitamina D; diabetes melito; patogênese

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“…Even though there was a decrease in the insulin requirements at 3 and 6 months in the calcitriol treated group, at the end of the first year there was no difference between the C-peptide levels or hemoglobin A1c between the two groups (Pitocco et al, 2006). Bizzarri et al investigated whether supplementation with calcitriol in recent onset autoimmune diabetes has a protective effect on the pancreatic beta cells and found that, at the doses used in the study, calcitriol did not confer protection against the autoimmune destruction of the beta cells (Bizzarri et al, 2010). In Germany, Walter et al supplemented newly diagnosed adult patients with 1,25(OH)2D3 for 18 months.…”

Section: Clinical Studies -Vitamin D and Type 1 Diabetesmentioning

confidence: 99%