No Relation between Psoriasis and Renal Abnormalities: A Case-Control Study

Abstract

Multiple observational studies have demonstrated that psoriasis is associated with nephropathy; however, the renal involvement in psoriasis remains largely a matter of debate. The current study was designed to investigate if psoriatic patients are at increased risk of renal abnormalities, in absence of any other comorbidities. Forty patients (11 women, 29 men, mean age 44.9 ± 15.45 years) with moderate to severe chronic plaque type psoriasis who were not under systemic therapy and 40 age- and gender-matched control subjects were enrolled in the study. Patients and controls with history of diabetes, hypertension, and chronic renal disease were excluded. Urinalysis by dipstick and microscopic evaluation and 24 h proteinuria and albuminuria were measured in all patients and controls. Patients with psoriasis and controls were not significantly different with respect to the prevalence of abnormal urinalysis (7.5% versus 5%, P = 1.0), mean 24 h proteinuria (70.40 ± 24.38 mg/24 h versus 89.40 ± 26.78 mg/24 h, P = 0.30), and albuminuria (14.15 ± 8.12 mg/24 h versus 16.62 ± 8.21 mg/24 h, P = 0.18). The presence of abnormal urinalysis was not more common in patients with psoriasis than in controls. Our study demonstrated that psoriatic patients without any other comorbidities are not at increased risk of kidney disease.

Urinary Orosomucoid as a Potential Marker of Inflammation in Psoriasis Vulgaris

“…The current study revealed that mean serum creatinine was higher among cases than control group (p=0.001), while serum creatinine wasn't significantly different between both groups. Also, other report conducted by Tehranchinia et al (31) have revealed that median serum levels of creatinine and CrCl weren't significantly different between both groups…”

Psoriasis and Renal Disorders: A Large-Scale Population-Based Study in Children and Adults

“…Therefore, it is not surprising that glomerulonephritis was reported in both adults and children with psoriasis [13][14][15][16][17][18][22][23][24][25][26][27][28][29][30][31]. Lately, interleukin-17, a proinflammatory factor detected in high levels in psoriasis patients, was found to also play a role in various renal diseases [46,47]. High levels of interleukin-17 in psoriasis may induce renal inflammation, resulting in glomerulonephritis and other renal injuries [7].…”

Chronic Kidney Disease in Patients with Psoriasis –A Hospital Based Cross Sectional Study

“…In a study of 40 patients with chronic plaque psoriasis with no other risk factors and 40 control patients, no increased risk was found to develop kidney disease. [ 15 ]…”