No relevant midbrain atrophy in Parkinson's disease

Mäkinen, Elina; Joutsa, Juho; Isotalo, Juuso; Kaasinen, Valtteri

doi:10.1111/ane.12551

Cited by 6 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Various PET tracers are available to evaluate the movement dysfunction in patients with MSA. 3,4 In some isolated neuropathologically confirmed MSA cases, DAT imaging can be either normal or decreased consistent with various clinical manifestations, suggesting heterogeneity of DAT distribution in MSA patients. DAT is a sodium-dependent facilitated diffusion transporter on the presynaptic membranes of dopaminergic nerve terminals.…”

mentioning

confidence: 99%

“…Molecular neuroimaging of the DAT defines integrity of dopamine terminals and provides a measurement to further aid diagnosis of uncertain parkinsonism. 3,4 In some isolated neuropathologically confirmed MSA cases, DAT imaging can be either normal or decreased consistent with various clinical manifestations, suggesting heterogeneity of DAT distribution in MSA patients. Previous imaging studies suggested that striatal DAT binding patterns differ in MSA-P and MSA-C. [5][6][7] However, there is still a need for larger samples sizes with added focus to clarify this disparity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Liu

Jiang

et al. 2018

Acta Neurol Scand

View full text Add to dashboard Cite

The subtypes of MSA studied here show significantly different spatial/anatomic patterns of striatonigral degeneration which may provide insights into their disease pathophysiology. Specifically, MSA-P patients exhibit an uneven and much greater pronounced loss of dopamine innervation, while a relatively uniform pattern is revealed in patients with the MSA-C. Furthermore, the typical reduction in DAT C-CFT binding in striatum is not present in all MSA-C patients, with a minority of cases showing normal DAT binding.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Liu

Jiang

et al. 2018

Acta Neurol Scand

View full text Add to dashboard Cite

show abstract

“…There are several possible interpretations for these discrepancies. First, in PD patients only slight midbrain atrophy has been detected, and there is no correlation between midbrain atrophy and striatal dopamine function (Makinen et al, 2016). As a potential precursor of PD, iRBD is thus believed to present mild midbrain atrophy or even no atrophy.…”

Section: Discussionmentioning

confidence: 99%

Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

Han¹

2018

http://isrctn.com/

View full text Add to dashboard Cite

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Ethics Committee of Huashan Hospital (approval No. KY2013-336) on January 6, 2014. This trial was registered in the ISRCTN registry (ISRCTN18238599).

show abstract

Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson’s patients

et al. 2017

View full text Add to dashboard Cite

Parkinson's disease (PD) patients show cognitive deficits that are relevant in terms of prognosis and quality of life. Degeneration of striatal dopaminergic afferents proceeds from dorsal/caudal to anterior/ventral and is discussed to account for some of these symptoms. Treatment with dopamine (DA) has differential effects on cognitive dysfunctions, improving some and worsening others. We hypothesized that cognitive performance during the dopaminergic OFF state correlates with DAT availability in the associative striatum. 16 PD patients underwent motor and cognitive examination ON and OFF DA. Global cognition was measured using the Montréal Cognitive Assessment (MoCA) test and executive functioning using a Stroop test. Nigrostriatal dopaminergic innervation was characterized with [I]FP-CIT SPECT. A connectivity atlas of the striatum was used to assess DAT availability in functionally defined striatal subregions. Correlations between imaging data and behavioral data OFF medication were calculated. Correlations between DAT availability and MoCA performance in the dopaminergic OFF state was strongest in the associative part of the striatum (r = 0.674, p = 0.004). MoCA test performance did not differ between the ON and the OFF state. There was no correlation of DAT availability with Stroop performance in the OFF state but performance was significantly better during the ON state. Not only motor but also cognitive dysfunctions in PD are associated with striatal dopaminergic depletion. Cognitive decline in non-demented PD patients goes along with nigrostriatal degeneration, most pronounced in the associative subdivision of the striatum. In addition, the present findings suggest that executive dysfunctions are ameliorated by DA whereas global cognition is not improved by dopaminergic medication.

show abstract

No relevant midbrain atrophy in Parkinson's disease

Abstract: Mild midbrain atrophy is present in PD and can be detected with MRI. However, the midbrain atrophy in PD is not associated with the level of striatal dopaminergic dysfunction, and midbrain measurements therefore cannot be used as a clinically useful predictor of dopamine function.

Cited by 6 publications

References 18 publications

Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson’s patients

Contact Info

Product

Resources

About