Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Bu, Lu-Lu; Liu, F.-T.; Jiang, Chenwei; Guo, Sisi; Yu, Huapeng; Zuo, Chuantao; Wu, Ping; Wang, J.

doi:10.1111/ane.12932

Cited by 33 publications

(40 citation statements)

References 31 publications

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“…For each 11 C-CFT PET scan, caudate and putamen dopamine transporter (DAT) binding was estimated for each hemisphere by the striatal-to-occipital ratio (SOR), defined as (striatum-occipital)/occipital radioactivity counts, and these values were averaged across hemispheres. 25…”

Section: Methodsmentioning

confidence: 99%

Preserved caudate function in young-onset patients with Parkinson’s disease: a dual-tracer PET imaging study

Yang

Liu

et al. 2019

Ther Adv Neurol Disord

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Parkinson’s disease (PD) is a highly heterogeneous clinical entity. Patients with young-onset PD (YOPD) show some characteristic manifestations to late-onset PD (LOPD). The current study aimed to investigate the cerebral dopaminergic and metabolic characteristics in YOPD with positron emission tomography (PET) imaging. In our study, 103 subjects (42 YOPD and 61 LOPD patients) accepted both 11C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (11C-CFT) and 18F-fluorodeoxyglucose (18F-FDG) cerebral PET imaging. Sixty-two patients out of 103 patients in our study completed the cognition tests. In this limited subsection, YOPD patients performed better in cognitive functioning than LOPD patients of similar disease duration. In 11C-CFT imaging, dopamine transporter binding in caudate was relatively spared in YOPD compared with lesions in putamen. In 18F-FDG PET, YOPD patients showed increased metabolism in basal ganglia relative to the healthy controls. When compared with LOPD patients, YOPD patients exhibited hypermetabolism in caudate and hypometabolism in putamen. Furthermore, the regional metabolic values in caudate correlated positively and moderately with the dopaminergic binding deficiency in caudate. The findings of this imaging study might offer new perspectives in understanding the characteristic manifestations in YOPD in light of better-preserved cognition function.

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Section: Methodsmentioning

confidence: 99%

Preserved caudate function in young-onset patients with Parkinson’s disease: a dual-tracer PET imaging study

Yang

Liu

et al. 2019

Ther Adv Neurol Disord

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“…MSA‐C is usually more severe, with a mean survival of eight years, while other ILOCAs seem to have an average lifespan . Nevertheless, there are reported cases of MSA‐C with longer lifespans and normal DATscans, raising questions about its spectrum and whether there are faster and slower forms, variants with mild or absence of autonomic features, or if all ILOCA could be MSA‐C …”

Section: Discussionmentioning

confidence: 99%

SPG7: The Great Imitator of MSA‐C Within the ILOCAs

Salgado

Latorre

Gamba

et al. 2018

Movement Disord Clin Pract

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“…A brain DAT binding template in Montreal Neurological Institute (MNI) space that was created by using 11 C-CFT PET and corresponding structural MR images of another group consisting of 16 normal controls was used to normalize the 11 C-CFT images. The procedures were presented in detail in former studies (Bu et al, 2018). As for 18 F-FDG images, template within the SPM software was used for normalization.…”

Section: Pet Imaging and Imaging Processingmentioning

confidence: 99%

Brain Metabolisms Involved in Self-Reported Quality of Mobility in Parkinson’s Disease

Liu

et al. 2020

Front. Neurosci.

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Background: Objective motor ratings and subjective motor complaints are both widely used in Parkinson's disease (PD). However, the objective basis to the self-perceived mobility quality is still not well elucidated. Purposes: We aimed to figure out the relevancy between the UPDRS motor scores and PDQ39 mobility sub-scores, and further explore whether physician-assessed motor dysfunctions and patients-reported mobility deficits have some shared mechanisms. Methods: 49 patients with PD who completed the PDQ39 scale were retrospectively included. The relevancy between mobility quality and UPDRS scores was assessed, as well as the related presynaptic dopaminergic binding (11 C-CFT) and glucose metabolism (18 F-FDG) in this dual-tracer PET imaging study. Results: Modest correlation was found between UPDRS motor score and the PDQ39 mobility sub-score (r = 0.440, p = 0.002). No correlation was found between PDQ39 mobility SI and the dopaminergic lesions in putamen; however, the strict correlation was found with the UPDRS motor scores. In terms of global PD related pattern (PDRP) scores, the two motor scores both correlated strictly. In the further regional metabolism exploration, cerebellum correlated positively with PDQ39 mobility sub-scores, and the frontal and parietal regions mainly correlated negatively with the motor quality scores. Conclusion: UPDRS motor scores and PDQ39 mobility scores were only modestly correlated. The mechanisms involved under mobility quality were beyond dopaminergic deficiency, including motor related cerebellum hyper-metabolism and non-motor related frontal hypo-metabolism. Conclusively, the self-reported mobility experience may have the neurophysiological basis related to both motor and non-motor manifestations in PD.

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Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

Cited by 33 publications

References 31 publications

Preserved caudate function in young-onset patients with Parkinson’s disease: a dual-tracer PET imaging study

Preserved caudate function in young-onset patients with Parkinson’s disease: a dual-tracer PET imaging study

SPG7: The Great Imitator of MSA‐C Within the ILOCAs

Brain Metabolisms Involved in Self-Reported Quality of Mobility in Parkinson’s Disease

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