NOB1: A Potential Biomarker or Target in Cancer

Ke, Weiwei; Lu, Zaiming; Zhao, Xiangxuan

doi:10.2174/1389450120666190308145346

Cited by 9 publications

(7 citation statements)

References 67 publications

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“…haematobium eggs leads to urothelial hyperplasia, a potentially pre-cancerous state [ 18 ]. Proteins including metalloreductase ( STEAP4 ) [ 41 ], platelet-activating factor acetylhydrolase ( Pla2g7 ) [ 42 ], disabled homolog 2 ( Dab2 ) [ 43 ], peptidyl-prolyl cis-trans isomerase ( Fkbp14 ) [ 44 ], stabilin-1 ( Stab1 ) [ 45 , 46 ], lysyl oxidase homolog 2 ( Loxl2 ) [ 47 ], U4/U6 small nuclear ribonucleoprotein ( Prpf3 ) [ 48 ], latent-transforming growth factor beta-binding protein ( Ltbp3 ) [ 49 ], RNA-binding protein ( Nob1 ) [ 50 ], isoform 1 of RNA-binding protein ( Raly ) [ 51 ], and probable glutathione peroxidase 8 ( Gpx8 ) [ 52 ] are all expressed in many different malignant tissues, including bladder tissue, and are linked with increased cell proliferation, oncogenic properties, and poor cancer prognosis. This is in line with our observations, as all these proteins were more highly expressed in egg-injected mice bladder tissue.…”

Section: Discussionmentioning

confidence: 99%

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

et al. 2022

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Urogenital schistosomiasis remains a major public health concern worldwide. In response to egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to date imply that the molecular mechanisms underlying pathology are not well-defined. We leveraged a mouse model of urogenital schistosomiasis to perform for the first time, proteome profiling of the early molecular events that occur in the bladder after exposure to S. haematobium eggs, and to elucidate the protein pathways involved in urogenital schistosomiasis-induced pathology. Purified S. haematobium eggs or control vehicle were microinjected into the bladder walls of mice. Mice were sacrificed seven days post-injection and bladder proteins isolated and processed for proteome profiling using mass spectrometry. We demonstrate that biological processes including carcinogenesis, immune and inflammatory responses, increased protein translation or turnover, oxidative stress responses, reduced cell adhesion and epithelial barrier integrity, and increased glucose metabolism were significantly enriched in S. haematobium infection. S. haematobium egg deposition in the bladder results in significant changes in proteins and pathways that play a role in pathology. Our findings highlight the potential bladder protein indicators for host-parasite interplay and provide new insights into the complex dynamics of pathology and characteristic bladder tissue changes in urogenital schistosomiasis. The findings will be relevant for development of improved interventions for disease control.

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Section: Discussionmentioning

confidence: 99%

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

et al. 2022

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“…Guo H et al had reported that Hspa1b is closely related to the occurrence of lung cancer [ 19 ]. NOB1 was a potential biomarker or target in cancer [ 20 ]. CRIP1 participates in regulation of proliferation, migration and invasion of breast cancer cells [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Sublethal heat treatment promotes breast cancer metastasis and its molecular mechanism revealed by quantitative proteomic analysis

Xia

et al. 2022

Aging

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Radiofrequency ablation (RFA) is a frequently used thermal ablation technique for breast tumors. The study aimed to identify the effect of sublethal heat treatment on biological function of breast cancer cells and reveal its potential molecular mechanism. The expression profile of dysregulated proteins in sublethal heat treated breast cancer cells was analyzed by quantitative proteomic analysis. The differentially expressed proteins in the sublethal heat treated breast cancer were identified. The potential biological functions of these proteins were evaluated. The proliferation and invasion ability of breast cancer cells were enhanced after sublethal heat treatment. The expression profile of proteins in sublethal heat treated breast cancer cells was abundant, and most of which were newly discovered. A total of 206 differentially expressed proteins were identified. Among them, 101 proteins were downregulated while 105 proteins were upregulated. GO and KEGG analysis indicated that various systems were involved in the process of sublethal heat treatment including cancer, immune system, et al. Immunohistochemistry staining showed that the expression of Heat shock protein 1B, NOB1 and CRIP1 was highly expressed while the expression of BCLAF1 was lower in sublethal heat treated group. The proliferation and invasion ability of breast cancer cells were enhanced after sublethal heat treatment. Sublethal heat treatment caused gene alterations in cancer and immune system. Heat shock protein 1B, NOB1 and CRIP1 were upregulated while BCLAF1 was downregulated in breast cancer after sublethal heat treatment.

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“…This is consistent with the observation that mouse bladder wall injection with S. haematobium eggs leads to urothelial hyperplasia, a potentially pre-cancerous state [18]. Proteins including metalloreductase ( STEAP4 ) [44], platelet-activating factor acetylhydrolase ( Pla2g7 ) [45], disabled homolog 2 ( Dab2 ) [46], peptidyl-prolyl cis-trans isomerase ( Fkbp14 ) [47], stabilin-1 ( Stab1 ) [48, 49], lysyl oxidase homolog 2 ( Loxl2 ) [50], U4/U6 small nuclear ribonucleoprotein ( Prpf3 ) [51], latent-transforming growth factor beta-binding protein ( Ltbp3 ) [52], RNA-binding protein ( Nob1 ) [53], isoform 1 of RNA-binding protein ( Raly ) [54], and probable glutathione peroxidase 8 ( Gpx8 ) [55] are all expressed in many different malignant tissues, including bladder tissue, and are linked with increased cell proliferation, oncogenic properties, and poor cancer prognosis. This is in line with our observations, as all these proteins were more highly expressed in egg-injected mice bladder tissue.…”

Section: Discussionmentioning

confidence: 99%

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

Osakunor

Ishida

Lamanna

et al. 2021

Preprint

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BackgroundUrogenital schistosomiasis remains a major public health concern worldwide. In response to egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to date imply that the molecular mechanisms underlying pathology have not been well-defined. We leveraged a mouse model of urogenital schistosomiasis to perform for the first time, proteome profiling of the early molecular events that occur in the bladder after exposure to S. haematobium eggs, and to elucidate the protein pathways involved in urogenital schistosomiasis-induced pathology.MethodsPurified S. haematobium eggs or control vehicle were microinjected into the bladder walls of mice. Mice were sacrificed seven days post-injection and bladder proteins isolated and processed for proteome profiling using mass spectrometry.ResultsWe demonstrate that biological processes including carcinogenesis, immune and inflammatory responses, increased protein translation or turnover, oxidative stress responses, reduced cell adhesion and epithelial barrier integrity, and increased glucose metabolism were significantly enriched in S. haematobium infection.ConclusionS. haematobium egg deposition in the bladder results in significant changes in proteins and pathways that play a role in pathology. Our findings highlight the potential bladder protein indicators for host-parasite interplay and provide new insights into the complex dynamics of pathology and characteristic bladder tissue changes in urogenital schistosomiasis. The findings will be relevant for development of improved interventions for disease control.Author summaryThe molecular mechanisms underlying the urinary and genital pathology from urogenital schistosomiasis have not been well-defined. This has mainly been due to limited mechanistic studies and the lack of a suitable animal model for S. haematobium infection. We leveraged a mouse model of urogenital schistosomiasis, along with proteomics analysis, to determine the early molecular events that occur in the bladder after exposure to S. haematobium eggs, and to define protein pathways that may be involved in morbidity from urogenital schistosomiasis infection. Our results show that S. haematobium egg deposition in the bladder results in significant changes in proteins and pathways that play a role in pathology. Biological processes including carcinogenesis, immune and inflammatory responses, increased protein translation or turnover, oxidative stress responses, reduced cell adhesion and epithelial barrier integrity, and increased glucose metabolism are significantly enriched in S. haematobium infection. Our findings highlight important protein indicators of host-parasite interactions in the bladder and their association with tissue changes in urogenital schistosomiasis. The findings presented here will be relevant for development of improved interventions for disease control, and contribute to realizing the 2021-2030 NTD goals by demonstrating evidence on the early events that occur during schistosome infection..

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NOB1: A Potential Biomarker or Target in Cancer

Cited by 9 publications

References 67 publications

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

Sublethal heat treatment promotes breast cancer metastasis and its molecular mechanism revealed by quantitative proteomic analysis

Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

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