Nobel Prizes: Contributions to Cardiology

Mesquita, Evandro Tinoco; Marchese, Luana; Dias, Danielle Warol; Barbeito, Andressa Brasil; Gomes, Jonathan Costa; Muradas, Maria Clara Soares; Lanzieri, Pedro Gemal; Gismondi, Ronaldo Altenburg

doi:10.5935/abc.20150041

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Previous analyses of cardiovascular research in the context of the Nobel Prize predominantly address the entirety of Nobel Prize laureates [3] or is limited to specific Nobel Prize laureates; for example, Willem Einthoven [4] (1860-1927) for the discovery of the electrocardiogram, Alexis Carrel [5] (1873-1944) for his work in the field of vascular surgery and transplantation, Werner Forssmann [6] for his contribution to the development of heart catheterisation and Joseph Erlanger [7] (1874-1965) for the discovery of different types of nerve fibres.…”

Section: Introductionmentioning

confidence: 99%

Who is who in cardiovascular research? What a review of Nobel Prize nominations reveals about scientific trends

2021

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Background Since 1901, at least 15 scholars who contributed to cardiovascular research have reveiced a Nobel prize in physiology or medicine. Methods Using the Nobel nomination database (nobelprize.org), which contains 5950 nominations in the accessible period from 1901 to 1953 in physiology or medicine, we listed all international nominees who contributed to cardiovascular research. We subsequently collected nomination letters and jury reports of the prime candidates from the archive of the Nobel Committee in Sweden to identify shortlisted candidates. Results The five most frequently nominated researchers with cardiovascular connections from 1901 to 1953 were, in descending order, the surgeon René Leriche (1879–1955) (FR) with a total of 79 nominations, the physiologist and 1924 Nobel laureate Willem Einthoven (1860–1927) (NL) (31 nominations), the surgeon Alfred Blalock (1899–1964) (US) (29 nominations), the pharmacologist and 1936 Nobel laureate Otto Loewi (1873–1961) (DE, AT, US) (27 nominations) and the paediatric cardiologist Helen Taussig (1898–1986) (US) (24 nominations). The research of these scholars merely hints at the width of topics brought up by nominators ranging from the physiological and pathological basics to the diagnosis and (surgical) interventions of diseases such as heart malformation or hypertension. Conclusion We argue that an analysis of Nobel Prize nominations can reconstruct important scientific trends within cardiovascular research during the first half of the twentieth century.

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Section: Introductionmentioning

confidence: 99%

Who is who in cardiovascular research? What a review of Nobel Prize nominations reveals about scientific trends

2021

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“…Besides cancer research, advancements in cardiovascular research contributed to an increase in life expectancy of around 3.73 years in the US from 1950 to 2000 (Murphy, Topel 2006). Many cardiovascular devices are products of this research contributing to health gains; several important cardiovascular device innovations -such as electrocardiogram, cardiac catheterization, computed tomography, and magnetic resonance -were products of Noble Prize-winning research (Mesquita et al 2015).…”

Section: Innovation Pathways In Cardiovascular Device Research and Development And Health Outcomesmentioning

confidence: 99%

Regional Innovation Systems of Medical Technology

Vadia¹,

Blankart

2021

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We investigated the role of external funding in cardiovascular device innovation across 31 countries in Europe. We rely on the knowledge production function (KPF) framework that establishes the knowledge output of a region as a function of innovatory effort and other characteristics of that region. In a cross-sectional analysis, we investigated regional variation in knowledge production by the number of publications in cardiovascular device research obtained from the bibliometric data of the world’s largest biomedical library, the US National Library of Medicine, 2014‒2017. We mapped these publications to product categories of medical devices approved for cardiovascular diseases by the US Food and Drug Administration. Considering spatial correlation across regions of Europe in our estimates of the KPF, we investigated the impact of two types of funding mechanisms: grants reported in the publications and the volume of European Union Horizon 2020 funding received by the innovating regions. We obtained 123,487 cardiovascular device-related publications distributed across 1,051 (75% of total) regions (NUTS-3 level). Receiving external funding strongly contributes to a region’s knowledge output. The estimated elasticities of innovatory effort range between 0.51 and 0.64. These estimates were consistently larger than the elasticities of other characteristics in the region measured by gross domestic product (0.14‒0.56). We also documented spillover effects from neighboring regions when the funding was measured by the grants reported in the publications, concluding that innovatory efforts in the form of external research investments are effective for promoting innovation in the medical device industry at the regional level.

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“…O advento do Cateter Central de Inserção Periférica (PICC) teve início no ano de 1711, com os estudos do fisiologista inglês Stephen Hales (1) .…”

Section: Introductionunclassified

Fatores Para Retirada De Cateter Central De Inserção Periférica Em Unidade De Terapia Intensiva Neonatal

Mittang

Stiegler

Schultz³

et al. 2020

Rev. baiana enferm.

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OBJETIVO: Identificar os principais fatores de retirada do cateter em recém-nascidos em unidade de terapia intensiva neonatal (UTIn). MÉTODO: Pesquisa descritiva, retrospectiva, transversal com abordagem. Para a análise estatística de associação foi utilizado o teste de associação de Qui-quadrado, adotou-se o nível de significância de 5%. RESULTADOS: Houve predomínio de recém-nascidos pré-termo (76,5%), do sexo feminino (50,3%), com diagnósticos clínicos de prematuridade (73,1%) e desconforto respiratório (68,3%). Os principais fatores de retirada do cateter central de inserção periférica (PICC) foram término de terapia (58,3%), infecção presumida do cateter/flebite (23,5%), infiltração (6%) e obstrução (6%). Foram encontradas associações estatisticamente significativas entre a idade gestacional (p<0,001), quantidade de diagnósticos do recém-nascido (p=0,018), posicionamento do cateter (p<0,01) e a variável desfecho “fatores de retirada do cateter PICC”. CONCLUSÃO: Esta pesquisa possibilitou identificar os principais fatores de retirada do PICC e poderá contribuir para o monitoramento e elaboração de estratégias para manutenção desse cateter.

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Nobel Prizes: Contributions to Cardiology

Cited by 6 publications

References 33 publications

Who is who in cardiovascular research? What a review of Nobel Prize nominations reveals about scientific trends

Who is who in cardiovascular research? What a review of Nobel Prize nominations reveals about scientific trends

Regional Innovation Systems of Medical Technology

Fatores Para Retirada De Cateter Central De Inserção Periférica Em Unidade De Terapia Intensiva Neonatal

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