2013
DOI: 10.1016/j.bbr.2013.05.025
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Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse

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Cited by 100 publications
(57 citation statements)
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“…Our observations also gain support by a study conducted by Lu et al (2010) in which they have shown that nobiletin attenuated cytotoxicity induced by H 2 O 2 induced oxidative stress in the PC12 cells by scavenging ROS, reducing MDA and restoring activities of anti-oxidants. In another study nobiletin showed protective effect against age-related cognitive impairment by reducing oxidative burden in the brain of mice (Nakajima et al, 2013). Nobiletin also protected against stroke prone hypertensive rats by mitigating usual age related increase in blood pressure and thrombogenicity in cerebral vessels through its anti-oxidant effect (Ikemura et al, 2012).…”
Section: Discussionmentioning
confidence: 96%
“…Our observations also gain support by a study conducted by Lu et al (2010) in which they have shown that nobiletin attenuated cytotoxicity induced by H 2 O 2 induced oxidative stress in the PC12 cells by scavenging ROS, reducing MDA and restoring activities of anti-oxidants. In another study nobiletin showed protective effect against age-related cognitive impairment by reducing oxidative burden in the brain of mice (Nakajima et al, 2013). Nobiletin also protected against stroke prone hypertensive rats by mitigating usual age related increase in blood pressure and thrombogenicity in cerebral vessels through its anti-oxidant effect (Ikemura et al, 2012).…”
Section: Discussionmentioning
confidence: 96%
“…Furthermore, nobiletinrich C. reticulata peels have been accepted as kampo medicine for the management of neurodegene rative disorders [9]. The neuroprotective effects of the citrus peels could be attributed to multiple mechanisms, Brought to you by | University of Ottawa OCUL Authenticated Download Date | 8/4/15 10:00 AM as Nakajima et al [11] showed that administration of nobiletin (a polymethoxylated flavone from citrus peels) to transgenic mice improved cognitive impairment and reduced oxidative stress. Similarly, another citrus peel phenolic compound, naringin, improved cognitive func tion in Alzheimer's disease transgenic mouse model by enhancing the autophosphorylation of calcium/calmo dulindependent protein kinase II [12] and also showed neuroprotection against 3nitropropionic acidinduced neurodegeneration in experimental rats through antioxi dative and antiinflammatory mechanisms [13].…”
Section: Discussionmentioning
confidence: 97%
“…Citrus peels have also been considered as dietary intervention in the management of neurodegenerative disorders, as Citrus reticulata peels have been accepted in Japan as dietary management for Alzheimer's disease [9]. Furthermore, citrus peel flavonoids can cross the bloodbrain barrier [10] and they have been shown to exert neuro protection in several animal models through induction of antioxidant enzymes and antiinflammatory and signaling properties [11][12][13].…”
Section: Introductionmentioning
confidence: 98%
“…Therefore, prebiotics may improve effectively the intestinal microflora of SAMP8 and delay the defects in learning and memory and emotional disorders. Antioxidative and anti-inflammatory agents present in food exacerbate the memory disorder and learning impairment in SAMP8 [1315], decrease amyloid- β deposition [16], and mitochondrial dysfunction [17]. Ueda et al [18] reported that the assessment by passive avoidance test in SAMP8 fed diet containing fish oil was better than that in SAMP8 fed high saturated fatty acids, because fish oil contains high polyunsaturated fatty acids.…”
Section: Introductionmentioning
confidence: 99%