Nocardiopsins: New FKBP12‐Binding Macrolide Polyketides from an Australian Marine‐Derived Actinomycete, <i>Nocardiopsis</i> sp.

Raju, Ritesh; Piggott, Andrew M.; Conte, Melissa; Tnimov, Zakir; Alexandrov, Kirill; Capon, Robert J.

doi:10.1002/chem.200902933

Cited by 39 publications

(32 citation statements)

References 20 publications

(23 reference statements)

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“…39 Many of them display interesting bioactivities such as FKBP12 binding activity, 26 apoptosis, 29 cytotoxicity, 31,33,37 macrophage activating properties, 34 and an inhibitory effect on TNF-α-induced NFκB activation. 39 However, little is known about the secondary metabolites of halophilic actinomycetes.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Tian

Xiang

Luo

et al. 2013

J. Agric. Food Chem.

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A new p-terphenyl 1 and a novel p-terphenyl derivative 3 bearing a benzothiazole moiety were isolated from halophilic actinomycete Nocardiopsis gilva YIM 90087, along with known p-terphenyl 2, antibiotic novobiocin 4, cyclodipeptides 5−13, and aromatic acids 14 and 15. Their structures were elucidated on the basis of the interpretation of spectral data and by comparison of the corresponding data with those reported previously. The p-terphenyl 1 showed antifungal activity against the three pathogenic fungi, including Fusarium avenaceum, Fusarium graminearum, and Fusarium culmorum, that caused Fusarium head blight with minimal inhibitory concentrations (MICs) of 8, 16, and 128 μg/mL, respectively. Compound 1 showed antifungal activity against Candida albicans with a MIC of 32 μg/mL and antibacterial activity against Bacillus subtilis with a MIC of 64 μg/mL. Novobiocin 4 showed antifungal activity against Pyricularia oryzae with a MIC of 16 μg/mL and antibacterial activity against B. subtilis with a MIC of 16 μg/mL and Staphylococcus aureus with a MIC of 64 μg/mL. The 1,1-diphenyl-2-picrylhydrazyl assay suggested that 1, 3, and 4 exhibited 54.9% (2 mg/mL), 14.3% (4 mg/mL), and 47.7% (2 mg/mL) free radical scavenging activity, respectively. The positively charged 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS +• ) scavenging assay indicated that 1, 3, 4, and 8 exhibited 68.6% (1 mg/mL), 28.4% (2 mg/mL), 78.2% (0.5 mg/mL), and 54.6% (2 mg/mL) ABTS +• scavenging capacity, respectively. The superoxide anion radical scavenging assay suggested that 4 exhibited 77.9% superoxide anion radical scavenging capacity at 2 mg/mL. N. gilva YIM 90087 is a new resource for novobiocin 4.

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Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Tian

Xiang

Luo

et al. 2013

J. Agric. Food Chem.

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“…Actinobacteria exhibit various physiological and metabolic properties such as the production of extracellular enzymes further the formation of a wide variety of secondary metabolites including some antibiotics in use today are derived from natural actinobacteria and fungi products (Raju et al, 2010;Porsani, et al, 2013;Manivasagan et al, 2014;Sathiyanarayanan et al, 2014;Rashad et al, 2015;Romano et al, 2016;Dalitz, et al, 2016;Alvarez et al, 2017). In addition, different styles of life are found among actinobacteria thus this phylum includes pathogens (eg.…”

Section: Introductionmentioning

confidence: 99%

First Record of Fungi and Actinobacteria Isolated from the Marine Sediment Collected in the Intertidal Region from an Island Located in the South of Brazil

Porsani¹,

Kolm²,

Pimentel³

2017

Int.J.Curr.Res.Aca.Rev.

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Article InfoMel Island is considered a Natural Historic Site of Paraná State, South Brazil, with approximately 2,760 ha, of which about 95% are protected as the Ecological Station and State Park. This is the first record that evaluates the presence of actinobacteria and fungi in this environment. This research studied the spatial variability of fungi and actinobacteria in the surface of fifteen intertidal stations in Mel Island, Brazil. The number of organisms was compared in relation to physical-chemical factors. We isolated 332 microorganisms. The results showed significance in the temperature of the sediments related to the time of the day on which sample was collected. There were significant differences in the amount of cultivated fungi and actinobacteria. The Principal Component Analysis (PCA) showed that there was an inverse correlation between the number of microorganisms and the temperature. The grain size and organic matter sediment did not interfere in the amount of fungi and actinobacteria. The results show the expansion of the knowledge about the microbiology in the regions between tides furthermore, this microorganisms collected from marine sediment can hold great promise as biological control agents and they might show ability to produce undescribed bioactive compounds yet.

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“…As actinobactérias apresentam diversas propriedades metabólicas e fisiológicas, com grande variedade de metabólitos secundários e produção de enzimas extracelulares de alta aplicabilidade nas indústrias (RAJU et al, 2010; ANZAI et al, 2008, DURAIPANDIYAN et al, 2010. As Streptomyces e outros actinomicetos são responsáveis por grande parte dos produtos metabólicos com atividade biotecnológicos (GAMA et al, 2012;PACHECO DA ROSA et al, 2013).…”

Section: Introductionunclassified

O Potencial Do Streptomyces Isolados Na Região De Maués Na Produção De Enzimas Hidrolíticas

Coelho

Borba

Melo

et al. 2017

CeN

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Resumo A área de produção de enzimas microbianas tem crescido nas últimas décadas, devido à utilização nos diversos campos industriais e com isso a necessidades de pesquisas com inovações dos produtos já existentes. As enzimas hidrolíticas são catalizadores biológicos com alta aplicabilidade em diversas áreas da biotecnologia industrial. A castanha-do-Brasil é uma possível fonte de nutrientes para o crescimento de micro-organismos em busca de Keywords: Hydrolytic enzymes; Streptomyces sp.; Brazil nutsCiência e Natura v.39 n. 2, 2017, p. 202 -210 203 IntroduçãoAs enzimas são substâncias orgânicas específicas, compostas por polímeros de aminoácidos, que atuam como catalisadores no metabolismo dos seres vivos (ROSAS; PANTANO FILHO, 2003). Devido sua alta aplicabilidade biotecnológica, a tecnologia enzimática se apresenta como uma opção interessante e rentável para a exploração econômica uma vez que desempenha diversos tipos de reações A aplicação de diferentes tipos de enzimas nas indústrias tem a possibilidade de tornar o processo biotecnológico mais proveitoso, com elevados rendimentos e baixos danos ao meio ambiente (HASAN; SHAH; HAMEED, 2006).Enzimas hidrolíticas são as mais utilizadas nos processos industriais, sendo aplicadas na hidrólise de várias substâncias naturais. Os grupos das proteases constituem o maior grupo de enzimas utilizadas industrialmente no mundo, movimentando a economia deste setor ativamente (PILLAI et al., 2011). Estas enzimas têm como função hidrolisar ligações peptídicas (LI et al., 2012) e podem ser obtidas de diferentes fontes, entretanto as proteases microbianas se destacam pela sua metabolização e baixo custo (AWAD et al., 2013;MOSTAFA et al., 2012).As amilases estão entre as mais importantes enzimas industriais, são aplicadas como aditivos em detergentes, indústrias de alimentos, fermentação, papel e têxtil, farmacêutica, médica e químico-analítica (PANDEY et al., 2000; SOARES et al., 2010).As enzimas lipolíticas catalisam a hidrólise de gorduras e óleos, são consideradas o terceiro maior grupo baseado no volume total de compras, onde o uso comercial foi estimado em um bilhão (JAEGER et al., 1999). Possuem diversas aplicações industriais, utilizadas como biocatalisadores ideais em química orgânica entre outros (TREICHEL et al., 2010;LOU et al., 2013;SHARMA; KANWAR, 2014).As fosfatases agem sobre compostos de fósforo, podendo hidrolisar uma variedade de ésteres e anidridos do ácido fosfórico e liberar fosfato, além de atuar em reações de transfosforilação de fosfoésteres de glicerol, fenol e ρ-nitrofenol, para vários aceptores, como, piridoxina e glicose (ZIMMER et al., 2009).As actinobactérias apresentam diversas propriedades metabólicas e fisiológicas, com grande variedade de metabólitos secundários e produção de enzimas extracelulares de alta aplicabilidade nas indústrias (RAJU et al., 2010; ANZAI et al., 2008, DURAIPANDIYAN et al., 2010. As Streptomyces e outros actinomicetos são responsáveis por grande parte dos produtos metabólicos com atividade biotecnológicos (GAMA...

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Nocardiopsins: New FKBP12‐Binding Macrolide Polyketides from an Australian Marine‐Derived Actinomycete, Nocardiopsis sp.

Cited by 39 publications

References 20 publications

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

First Record of Fungi and Actinobacteria Isolated from the Marine Sediment Collected in the Intertidal Region from an Island Located in the South of Brazil

O Potencial Do Streptomyces Isolados Na Região De Maués Na Produção De Enzimas Hidrolíticas

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