Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp. HB-J378

Xu, Dongbo; Nepal, Keshav Kumar; Chen, Jing; Harmody, Dedra; Zhu, Haining; McCarthy, Peter J.; Wright, Amy E.; Wang, Guojun

doi:10.1016/j.synbio.2018.10.008

Cited by 35 publications

(25 citation statements)

References 35 publications

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“…ROESY correlations between H-9 and H-12 positioned H-12/H-12' syn to H-9/H-9', whereas NOE correlations of methyl-16 with H-11 and H-13a signified that methyl-16/16' is in on the same face as H-11/11' (Figure 3). These The Δ 4,5 , Δ 6,7 , Δ 20,21 , Δ 22,23 double bonds were established as E and the Δ 8,9 , Δ 10,11 , Δ 20,21 , Δ 22,23 double bonds as Z configurated. The methyl substituted Δ 2,3 , Δ 16,17 , Δ 18,19 22 micromonosporin A (24 membered ring), 23 as well as lobosamide, mirilactam, micromonolactam, and sceliphrolactam (all with 26 membered rings).…”

Section: Resultsmentioning

confidence: 99%

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Kenalactams A–E, Polyene Macrolactams Isolated from Nocardiopsis CG3

et al. 2019

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Actinobacteria are one of the most important phyla of microorganisms that produce a wide variety of bioactive secondary metabolites, 1,2 including many clinically used antibiotics and anticancer drugs. 3,4 A contemporary strategy for obtaining new bioactive compounds is based on the isolation of rare actinomycetes from neglected environments, 5 which should contain gene clusters for biosynthetizing novel secondary metabolites. 6 One of the pharmaceutically and biotechnologically important rare actinomycetes that attracts natural products researchers is the genus Nocardiopsis. 7,8 Species of this genus are aerobic, Gram-positive, non-acid-fast, and their aerial mycelia bear long chains of spores. 9,10 Nocardiopsis species were mainly recovered from salty habitats. The members of this genus produce an array of bioactive compounds that may aid their survival under these conditions. 11 In recent years many new natural products, belonging to different classes of molecules, including polyketides and peptides, 12,13,14 were isolated from Nocardiopsis species. 15,16 These classes display cytotoxic, 17 antimicrobial, 18 and immunomodulatory activities. 19 Recently, three new angucyclines, nocardiopsistins A-C, with anti-Methicillin-Resistant Staphylococcus aureus (MRSA) activity were isolated from a marine sponge-derived Nocardiopsis sp. HB-J378, 20 and a new cytotoxic cyclic peptide was obtained from the marine sponge-associated Nocardiopsis sp. UR67. 14 According to the World Health Organization (WHO, 2018), «Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018 », hence it is necessary to continue the discovery of new classes of molecules with cytotoxic activity, which may be further developed as anticancer drugs. 14 In fact, cytotoxicity-guided fractionation of the crude extract of the marine obligate actinomycetes, Salinispora tropica, led to the isolation of salinosporamide A, which entered phase I human clinical trials for the treatment of multiple myeloma. 21 In the course of screening for new bioactive metabolites from our collection of actinobacteria, which had been isolated from different areas of Algeria, Nocardiopsis CG3

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Section: Resultsmentioning

confidence: 99%

“…19 Recently, three new angucyclines, nocardiopsistins A-C, with anti-Methicillin-Resistant Staphylococcus aureus (MRSA) activity were isolated from a marine sponge-derived Nocardiopsis sp. HB-J378, 20 and a new cytotoxic cyclic peptide was obtained from the marine sponge-associated Nocardiopsis sp. UR67.…”

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confidence: 99%

Kenalactams A–E, Polyene Macrolactams Isolated from Nocardiopsis CG3

et al. 2019

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“…Three novel angucycline nocardiopsistins were isolated from marine sponge-derived Nocardiopsis sp. with anti-MRSA activity [ 100 ]. In a study of twenty strains of actinomycetes, from the mangrove ecosystem of the Andaman Islands, thirteen strains showed broad-spectrum activity against Gram-positive and Gram-negative bacteria.…”

Section: Medical Applicationsmentioning

confidence: 99%

Marine Actinomycetes, New Sources of Biotechnological Products

et al. 2021

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The Actinomycetales order is one of great genetic and functional diversity, including diversity in the production of secondary metabolites which have uses in medical, environmental rehabilitation, and industrial applications. Secondary metabolites produced by actinomycete species are an abundant source of antibiotics, antitumor agents, anthelmintics, and antifungals. These actinomycete-derived medicines are in circulation as current treatments, but actinomycetes are also being explored as potential sources of new compounds to combat multidrug resistance in pathogenic bacteria. Actinomycetes as a potential to solve environmental concerns is another area of recent investigation, particularly their utility in the bioremediation of pesticides, toxic metals, radioactive wastes, and biofouling. Other applications include biofuels, detergents, and food preservatives/additives. Exploring other unique properties of actinomycetes will allow for a deeper understanding of this interesting taxonomic group. Combined with genetic engineering, microbial experimental evolution, and other enhancement techniques, it is reasonable to assume that the use of marine actinomycetes will continue to increase. Novel products will begin to be developed for diverse applied research purposes, including zymology and enology. This paper outlines the current knowledge of actinomycete usage in applied research, focusing on marine isolates and providing direction for future research.

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“…HB‐J378 ( Table 1, Figure 1). Nocardiopsistin 2 showed the best anti‐Methicillin‐Resistant Staphylococcus Aureus (MRSA) activity with the same minimum inhibitory concentration (MIC=3.12 μg/mL), whereas both nocardiopsistins 1 and 3 merely possessed moderate potencies against MRSA with MIC value of 12.5 μg/mL [16] . The results indicated the carbonyl oxygen atom (=O) attached to the side‐ring of nocardiopsistin (C‐4) is essential for the anti‐MRSA activity.…”

Section: Marine‐based Polyketides With Diverse Bioactivitiesmentioning

confidence: 99%

Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019

Wang

Sheng

et al. 2020

Chemistry & Biodiversity

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Marine organism‐associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine‐based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well. We expected that this review would be helpful for future in‐depth research and development of marine‐based bioactive polyketides.

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Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp. HB-J378

Cited by 35 publications

References 35 publications

Kenalactams A–E, Polyene Macrolactams Isolated from Nocardiopsis CG3

Kenalactams A–E, Polyene Macrolactams Isolated from Nocardiopsis CG3

Marine Actinomycetes, New Sources of Biotechnological Products

Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019

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