Nociceptin and Meiosis during Spermatogenesis in Postnatal Testes

Eto, Kojiro

doi:10.1016/bs.vh.2014.10.003

Cited by 13 publications

(6 citation statements)

References 45 publications

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“…Gonadotropins (FSH and LH) and sex steroid hormones (E2 and T) are key hormones in the HPGL axis . FSH is a glycoprotein that promotes estradiol production and the secretion of gonadal hormones in females and promotes pubertal spermatogenesis and induces Sertoli cells to secrete androgen binding protein in males. , LH stimulates the production of androgens in males and secretion of progesterone and estrogen in females . FSH, in conjunction with LH, acts as a vital role in reproduction .…”

Section: Discussionmentioning

confidence: 99%

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Qian

Zhang

et al. 2020

Environ. Sci. Technol.

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Boscalid is a succinate dehydrogenase inhibitor fungicide and is frequently detected in surface water. Due to the frequent detection of boscalid, we evaluated its impact on the reproduction of adult zebrafish following a 21 d exposure to 0, 0.01, 0.1, and 1.0 mg/L. Following exposure to boscalid, the fertility of female zebrafish and fertilization rate of spawning eggs were reduced in a concentration-dependent manner up to a respective 87% and 20% in the highest concentration. A significant 16% reduction in the percentage of late vitellogenic oocytes was noted in ovaries, and a significant 74% reduction in the percentage of spermatids in testis was also observed after treatment with 1.0 mg/L. 17β-Estradiol (E2) concentrations decreased significantly in females (34% decrease) but significantly increased in males (15% increase) following 1.0 mg/L boscalid treatment. The expression of genes (such as era, er2b, cyp19a, and cyp19b) related to the hypothalamus-pituitary-gonad-liver (HPGL) axis was significantly altered and positively correlated with E2 concentrations in female and male zebrafish (p < 0.05). Molecular docking results revealed that the binding modes between boscalid and target proteins (ER and CYP19) of zebrafish were similar to that of the reference compounds and the target proteins. The binding energies indicate that boscalid may have a weak estrogen-like binding effect or CYP19 inhibition, potentially altering the HPGL axis, thereby reducing E2 concentrations and fecundity in females. In contrast, boscalid caused significant induction of E2 steroidogenesis and subsequent feminization of gonads in males, indicating gender-specific adverse outcome pathways.

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Section: Discussionmentioning

confidence: 99%

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Qian

Zhang

et al. 2020

Environ. Sci. Technol.

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“…The PNOC gene encodes the precursor for biologically active peptides, such as nociceptin, which have been related to several physiological roles in the central nervous system. Additionally, a study suggested that nociceptin plays a key function in meiosis during spermatogenesis [85].…”

Section: Discussionmentioning

confidence: 99%

A genome-wide single nucleotide polymorphism and copy number variation analysis for number of piglets born alive

et al. 2019

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Background In this study we integrated the CNV (copy number variation) and WssGWAS (weighted single-step approach for genome-wide association) analyses to increase the knowledge about number of piglets born alive, an economically important reproductive trait with significant impact on production efficiency of pigs. Results A total of 3892 samples were genotyped with the Porcine SNP80 BeadChip. After quality control, a total of 57,962 high-quality SNPs from 3520 Duroc pigs were retained. The PennCNV algorithm identified 46,118 CNVs, which were aggregated by overlapping in 425 CNV regions (CNVRs) ranging from 2.5 Kb to 9718.4 Kb and covering 197 Mb (~ 7.01%) of the pig autosomal genome. The WssGWAS identified 16 genomic regions explaining more than 1% of the additive genetic variance for number of piglets born alive. The overlap between CNVR and WssGWAS analyses identified common regions on SSC2 (4.2–5.2 Mb), SSC3 (3.9–4.9 Mb), SSC12 (56.6–57.6 Mb), and SSC17 (17.3–18.3 Mb). Those regions are known for harboring important causative variants for pig reproductive traits based on their crucial functions in fertilization, development of gametes and embryos. Functional analysis by the Panther software identified 13 gene ontology biological processes significantly represented in this study such as reproduction, developmental process, cellular component organization or biogenesis, and immune system process, which plays relevant roles in swine reproductive traits. Conclusion Our research helps to improve the understanding of the genetic architecture of number of piglets born alive, given that the combination of GWAS and CNV analyses allows for a more efficient identification of the genomic regions and biological processes associated with this trait in Duroc pigs. Pig breeding programs could potentially benefit from a more accurate discovery of important genomic regions. Electronic supplementary material The online version of this article (10.1186/s12864-019-5687-0) contains supplementary material, which is available to authorized users.

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“…PRPF6 is a key regulator of androgen receptor (AR), interacts with the N-terminus of AR, and enhances AR-mediated transactivation (Liu et al, 2021). OPRL1 plays an important role in spermatogenesis and meiosis through follicle-stimulating hormone (FSH) (Eto, 2015). SOX18 is an important regulator of vascular development, which is essential in angiogenesis and vascular endothelial cell differentiation (Fontijn et al, 2014).…”

Section: Candidate Genes Associated With the Strongest Selection Signalmentioning

confidence: 99%

Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat

Xiong

Bao

et al. 2023

Front. Genet.

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The dairy goat is one of the earliest dairy livestock species, which plays an important role in the economic development, especially for developing countries. With the development of agricultural civilization, dairy goats have been widely distributed across the world. However, few studies have been conducted on the specific characteristics of dairy goat. In this study, we collected the whole-genome data of 89 goat individuals by sequencing 48 goats and employing 41 publicly available goats, including five dairy goat breeds (Saanen, Nubian, Alpine, Toggenburg, and Guanzhong dairy goat; n = 24, 15, 11, 6, 6), and three goat breeds (Guishan goat, Longlin goat, Yunshang Black goat; n = 6, 15, 6). Through compared the genomes of dairy goat and non-dairy goat to analyze genetic diversity and selection characteristics of dairy goat. The results show that the eight goats could be divided into three subgroups of European, African, and Chinese indigenous goat populations, and we also found that Australian Nubian, Toggenburg, and Australian Alpine had the highest linkage disequilibrium, the lowest level of nucleotide diversity, and a higher inbreeding coefficient, indicating that they were strongly artificially selected. In addition, we identified several candidate genes related to the specificity of dairy goat, particularly genes associated with milk production traits (GHR, DGAT2, ELF5, GLYCAM1, ACSBG2, ACSS2), reproduction traits (TSHR, TSHB, PTGS2, ESR2), immunity traits (JAK1, POU2F2, LRRC66). Our results provide not only insights into the evolutionary history and breed characteristics of dairy goat, but also valuable information for the implementation and improvement of dairy goat cross breeding program.

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Nociceptin and Meiosis during Spermatogenesis in Postnatal Testes

Cited by 13 publications

References 45 publications

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

A genome-wide single nucleotide polymorphism and copy number variation analysis for number of piglets born alive

Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat

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