Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats

Kotlińska, Jolanta; Rafalski, Piotr; Biała, Grażyna; Dyląg, Tomasz; Rolka, Krzysztof; Silberring, Jerzy

doi:10.1016/s0014-2999(03)02081-8

Cited by 59 publications

(58 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initial studies (in rats) showed that single (Narayanan and Maidment, 1999) or repeated (Narayanan et al, 2002) administration of N/OFQ into the ventral tegmental area (the source of mesocorticolimbic dopamine neurons) cross-sensitizes the locomotor response to subsequent cocaine administration. Contrasting with these were subsequent studies showing that escalating doses of i.c.v.-administered N/OFQ suppresses behavioral sensitization to cocaine or amphetamine (Kotlinska et al, 2003). However, in our previous studies of behavioral sensitization to a smaller number of METH administrations, we found nonsignificant tendencies toward attenuated rates of sensitization in NOP receptor KO mice (Okabe et al, 2005).…”

Section: Role Of Endogenous N/ofq In Behavioral Sensitizationcontrasting

confidence: 99%

“…These results are consistent with previous studies showing that exogenous N/OFQ administration suppresses the acquisition or expression of drug-induced CPP (Ciccocioppo et al, 1999(Ciccocioppo et al, , 2000Murphy et al, 1999;Kotlinska et al, 2003;Kuzmin et al, 2003;Zhao et al, 2003;Sakoori and Murphy, 2004).…”

Section: Role Of Endogenous N/ofq In Balancing Hedonic Statesupporting

confidence: 93%

“…(1) N/OFQ or synthetic NOP receptor agonists suppress reward, as measured by the acquisition of conditioned place preference (CPP, a behavioral model used for assessing the rewarding properties of stimuli, see Bardo and Bevins, 2000), induced by cocaine (Sakoori and Murphy, 2004), morphine (Murphy et al, 1999;Ciccocioppo et al, 2000;Ciccocioppo et al, 2003;Sakoori and Murphy, 2004;Shoblock et al, 2005), ethanol (Ciccocioppo et al, 1999;Kuzmin et al, 2003), methamphetamine (METH, Zhao et al, 2003), and amphetamine (Kotlinska et al, 2003). (2) N/OFQ suppresses the development of cocaine- and amphetamine-induced behavioral sensitization (Kotlinska et al, 2003); a phenomenon believed to model some aspects of drug craving and psychosis (see Robinson and Berridge, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…(2) N/OFQ suppresses the development of cocaine- and amphetamine-induced behavioral sensitization (Kotlinska et al, 2003); a phenomenon believed to model some aspects of drug craving and psychosis (see Robinson and Berridge, 2001). (3) N/OFQ suppresses oral or instrumental ethanol self-administration and reinstatement of ethanol self-administration (Ciccocioppo et al, 1999(Ciccocioppo et al, , 2002(Ciccocioppo et al, , 2003(Ciccocioppo et al, , 2004aEconomidou et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Endogenous Nociceptin (Orphanin FQ) Suppresses Basal Hedonic State and Acute Reward Responses to Methamphetamine and Ethanol, but Facilitates Chronic Responses

Sakoori

Murphy

2007

Neuropsychopharmacol

View full text Add to dashboard Cite

The opioid peptide nociceptin (orphanin FQ) suppresses drug reward, drug self-administration, and impedes some of the processes believed to underlie the transition to addiction. As virtually all previous studies have used administration of nociceptin receptor agonists to evaluate the role of nociceptin on addiction-like behavior, the current study used a pharmacological (nociceptin receptor antagonist) and genetic (nociceptin receptor knockout mice) approach to elucidate the role of endogenous nociceptin. The nociceptin receptor antagonist UFP-101 induced a modest place preference, and enhanced the conditioned place preference induced by methamphetamine. In agreement with this, nociceptin receptor knockout mice had slightly enhanced methamphetamine and ethanol conditioned place preferences compared to wild-type mice. This effect did not appear to depend on differences in learning ability, as nociceptin receptor knockout mice had slightly weaker-conditioned place aversions to lithium chloride, the k-opioid receptor agonist, U50488H, and the general opiate antagonist, naloxone. The development of behavioral sensitization to methamphetamine was lower in nociceptin receptor knockout mice, and attenuated by UFP-101 administration to wild-type mice. Additionally, ethanol consumption and preference in a two-bottle choice test was lower in nociceptin receptor knockout mice, though ethanol-stimulated locomotion was stronger. Whereas the rewarding effect of methamphetamine and ethanol following chronic treatment, as measured by place conditioning, strengthened in wild-type mice, this effect was absent in nociceptin receptor knockout mice. These results suggest that endogenous N/OFQ suppresses basal and drug-stimulated increases in hedonic state, and plays either a permissive or facilitatory role in the development of addiction.

show abstract

Section: Role Of Endogenous N/ofq In Behavioral Sensitizationcontrasting

confidence: 99%

Section: Role Of Endogenous N/ofq In Balancing Hedonic Statesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Endogenous Nociceptin (Orphanin FQ) Suppresses Basal Hedonic State and Acute Reward Responses to Methamphetamine and Ethanol, but Facilitates Chronic Responses

Sakoori

Murphy

2007

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…In parallel with this, ICV administration of OFQ/N has been reported to block the development of morphine-induced CPP in rats (Ciccocioppo et al, 2000;. OFQ/N has also been demonstrated to attenuate the acquisition of amphetamine-induced CPP (Kotlinska et al, 2003) and expression of cocaine-induced CPP in rats (Kotlinska et al, 2002). Furthermore, ICV administration of OFQ/N has been shown to attenuate the development of cocaine-induced CPP in mice .…”

Section: Introductionmentioning

confidence: 75%

The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine

et al. 2008

View full text Add to dashboard Cite

Previous studies have shown that orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL-1) receptor, reduces the rewarding and addictive properties of cocaine and other drugs of abuse. In the present study, using the conditioned place preference (CPP) paradigm, as an animal model of drug reward, we assessed whether the rewarding action of acute cocaine would be altered in mice lacking the ORL-1 receptor or in wild type mice treated with J-113397, an ORL-1 receptor antagonist, relative to their saline-treated controls. On day 1, mice were tested for their baseline place preferences, in which each mouse was placed in the neutral chamber of a threechambered CPP apparatus, allowed to freely explore all the chambers and the amount of time that a mouse spent in each conditioning chamber was recorded for 15 min. On days 2-3, mice received once daily alternate-day saline/cocaine (15 or 30 mg/kg) conditioning for 30 min. On day 4, mice were tested for their postconditioning preferences, as described for day 1. In a subsequent study, the effect of J-113397 (3 mg/kg) on the rewarding action of acute cocaine (15 mg/kg) was also examined in wild type mice. Our results showed that mice lacking the ORL-1 receptor expressed greater CPP than their wild type littermates. Furthermore, the rewarding action of cocaine was enhanced in the presence of J-113397 in wild type mice. Together, the present results suggest that the endogenous OFQ/N/ORL-1 receptor system is involved in the rewarding action of acute cocaine.

show abstract

Identification of neuropeptide receptors expressed by melanin‐concentrating hormone neurons

Parks

Wang

et al. 2014

J of Comparative Neurology

View full text Add to dashboard Cite

Melanin-concentrating Hormone (MCH) is a 19 amino acid cyclic neuropeptide that acts in rodents via the MCH receptor 1 (MCHR1) to regulate a wide variety of physiological functions. MCH is produced by a distinct population of neurons located in the lateral hypothalamus (LH) and zona incerta (ZI) but MCHR1 mRNA is widely expressed throughout the brain. The physiological responses and behaviors regulated by the MCH system have been investigated, but less is known about how MCH neurons are regulated. The effects of most classical neurotransmitters on MCH neurons have been studied, but those of neuropeptides are poorly understood. In order to gain insight into how neuropeptides regulate the MCH system, we investigated which neuropeptide receptors are expressed by MCH neurons using double in situ hybridization. In all, twenty receptors, selected based upon either a suspected interaction with the MCH system or demonstrated high expression levels in the LH and ZI, were tested to determine whether they are expressed by MCH neurons. Overall, eleven neuropeptide receptors were found to exhibit significant colocalization with MCH neurons: Nociceptin / Orphanin FQ Opioid receptor (NOP), MCHR1, both Orexin receptors (ORX), Somatostatin receptor 1 and 2 (SSTR1, SSTR2), the Kisspeptin receotor (KissR1), Neurotensin receptor 1 (NTSR1), Neuropeptide S receptor (NPSR), Cholecystokinin receptor A (CCKAR) and the κ-opioid receptor (KOR). Of these receptors, six have never before been linked to the MCH system. Surprisingly, several receptors thought to regulate MCH neurons displayed minimal colocalization with MCH, suggesting that they may not directly regulate the MCH system.

show abstract

Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats

Cited by 59 publications

References 53 publications

Endogenous Nociceptin (Orphanin FQ) Suppresses Basal Hedonic State and Acute Reward Responses to Methamphetamine and Ethanol, but Facilitates Chronic Responses

Endogenous Nociceptin (Orphanin FQ) Suppresses Basal Hedonic State and Acute Reward Responses to Methamphetamine and Ethanol, but Facilitates Chronic Responses

The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine

Identification of neuropeptide receptors expressed by melanin‐concentrating hormone neurons

Contact Info

Product

Resources

About