Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice

Abstract

The mechanism of the analgesic effect of nitrous oxide (N(2)O) has not been completely clarified. Although we have reported that the analgesic effect of N(2)O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N(2)O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N(2)O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N(2)O was suppressed by the intraperitoneal administration of JTC-801.

Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac

“…Different neurotransmitter systems such as serotoninergic, catecholaminergic, cholinergic, dopaminergic, and opioidergic may contribute in the modulation of acetic acid-induced pain transmission in the central nervous system. [ 19 ] Peripherally, in addition to the direct stimulation of pain receptors, intraperitoneal injection of acetic acid also leads to the production of inflammatory substances such as type E prostaglandins which are responsible for pain and writhing responses. [ 19 ]…”

“…[ 19 ] Peripherally, in addition to the direct stimulation of pain receptors, intraperitoneal injection of acetic acid also leads to the production of inflammatory substances such as type E prostaglandins which are responsible for pain and writhing responses. [ 19 ]…”

“…[ 12 13 ] Peripherally, Coumarin derivatives, another PDS extract constituents, can inhibit lipid production and enhance the removal of free oxygen radicals. [ 11 12 13 14 15 16 17 18 19 20 ] Following the tissue damage, similar to what occurs after intraperitoneal injection of acetic acid; the group E prostaglandins are produced in the abdominal cavity and help the process of inflammation and intensification of pain, through sensitizing the nerve endings to bradykinin, histamine, and other released transmitters. [ 21 ] Coumarin and its derivatives, 7-hydroxy Coumarin, inhibit the production of prostaglandins E through inhibition of the cyclooxygenase enzyme systems, and results in the reduction of inflammation and pain induced by acetic acid.…”