Nocturia: aetiology and treatment in adults

Dani, Hasan; Esdaille, Ashanda; Weiss, Jeffrey P.

doi:10.1038/nrurol.2016.134

Cited by 53 publications

(65 citation statements)

References 137 publications

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“…Reduced bladder capacity is considered another factor affecting nocturia [7-9]. A mismatch between bladder capacity and the urine production rate induces reduced bladder capacity at night, resulting in nocturia [7]. Thus, our findings add a novel concept concerning the pathophysiology of nocturia, which is a disruption in the change of the adaptation ability of the bladder for the urine production rate between day and night applicable to reduced bladder capacity at night.…”

Section: Discussionmentioning

confidence: 77%

“…One major contributor to nocturia in aged people is a nocturnal overproduction of urine [3, 5, 7, 14]. However, nocturnal polyuria is present even in patients without nocturia [11].…”

Section: Discussionmentioning

confidence: 99%

“…These facts suggest that the disruption of the adaptation ability of the bladder or the change between day and night may also cause refractory nocturia in addition to nocturnal polyuria. Reduced bladder capacity is considered another factor affecting nocturia [7-9]. A mismatch between bladder capacity and the urine production rate induces reduced bladder capacity at night, resulting in nocturia [7].…”

Section: Discussionmentioning

confidence: 99%

“…The International Continence Society defines nocturia as “the complaint that the individual has to wake at night one or more times to void” [6]. Various etiologies of nocturia have been proposed and are thought to involve multiple factors, including polyuria, nocturnal polyuria, reduced bladder capacity, sleep disorders, and a combination of these factors [7-9]. The frequency volume chart (FVC) is one of the most important tools for determining the factors contributing to nocturia in individuals [7, 9].…”

Section: Introductionmentioning

confidence: 99%

“…An analysis of the information from the FVC can be used to diagnose the underlying pathophysiology of individual patients’ nocturia [7]. …”

Section: Introductionmentioning

confidence: 99%

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Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Kira¹,

Mitsui²,

Miyamoto³

et al. 2018

Urol Int

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Introduction: To investigate the association between bladder capacity and the urine production rate in aged men with or without nocturia using a frequency volume chart (FVC). Materials and Methods: One-hundred and thirty-eight men aged 65–80 years were enrolled. After the International Prostate Symptom Score (IPSS) and 3 consecutive days FVC were evaluated, men were divided into 2 groups: Nocturia group, with any total IPSS, and ≥1.5 micturition on average at night; and Control group, with total IPSS < 8 and < 1.5 micturition on average at night. Each parameter was compared between the 2 groups using unpaired t tests. Linear and multiple regression analyses were performed between the urine production rate and volume/voids. Results: Men numbering 45 and 21 were assigned to the Nocturia and Control groups respectively. There were no differences in background factors between the 2 groups. Volume/voids positively correlated with the urine production rate in both groups for day and night. A multivariate regression model also showed the same results. In the Control group, the degree of slope at night was higher than that during the day. However, in the Nocturia group, there were no differences in the degree of slope between day and night. Conclusions: This novel finding has led to a possibility for resolving nocturia.

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Section: Discussionmentioning

confidence: 77%

“…One major contributor to nocturia in aged people is a nocturnal overproduction of urine [3, 5, 7, 14]. However, nocturnal polyuria is present even in patients without nocturia [11].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…An analysis of the information from the FVC can be used to diagnose the underlying pathophysiology of individual patients’ nocturia [7]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Kira¹,

Mitsui²,

Miyamoto³

et al. 2018

Urol Int

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Lifestyle habits associated with nocturnal urination frequency: The Nagahama study

Tabara

Matsumoto

Murase

et al. 2019

Neurourology and Urodynamics

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Background Nocturia is a risk factor for poor quality of life and increased mortality. This study was aimed to clarifying dietary habits, eating behaviors, and sleep characteristics associated with nocturia to identify modifiable lifestyle factors for nocturia. Methods This cross‐sectional study included 5683 community residents (64.5 ± 7.7 years old). The frequency of nocturnal urination was recorded for 1 week using a sleep diary. The frequency of food intake, unfavorable eating behaviors, and sleep characteristics that may have influence on salt intake and wasting were obtained using a structured questionnaire. Results The frequency of nocturnal urination was increased with age (β = .312, P < .001). Other basic factors associated with the frequency were the male sex (β = .090), hypertension (β = .038), sleep apnea (β = .030), B‐type natriuretic peptide level (β = .089), and spot urine sodium excretion (β = −.058). Dietary factors independently associated with nocturnal urination frequency were coffee (≥1 time/day: β = −.059, P < .001) and green vegetable consumption (≥1 time/week: β = −.042, P = .001), whereas habitual intake of dairy products, miso soup, and alcohol were not associated with urination frequency. Later bedtime was inversely associated with nocturnal urination frequency independent of sleep duration (before 23:00: β = −.096; before 24:00: β = −.225; after midnight: β = −.240; all P < .001). Conclusion Coffee and green vegetable consumption and later bedtime but not sleep duration are lifestyle factors associated with nocturnal urination frequency.

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Daily salt intake is associated with leg edema and nocturnal urinary volume in elderly men

Yoshikawa

Torimoto

Hirayama

et al. 2020

Neurourology and Urodynamics

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Aims There is accumulating evidence that excessive salt intake contributes to nocturnal polyuria. We aimed to investigate the relationship between salt intake, leg edema, and nocturnal urine volume (NUV) to assess the etiology of nocturnal polyuria. Methods A total of 56 men aged ≥60 years who were hospitalized for benign prostatic hyperplasia or with suspected prostatic cancer were enrolled. Urine frequency‐volume charts of the patients were maintained, and they underwent bioelectrical impedance analysis twice daily (at 5:00 pm and 6:00 am) and examination of blood (brain natriuretic peptide levels) and urine (sodium and creatinine levels and osmotic pressure) samples once daily (at 6:00 am). Free‐water clearance, solute clearance, and sodium clearance at night were measured, and daily salt intake was estimated. Results The data of 52 patients were analyzed. Daily salt intake positively correlated with leg edema at 5:00 pm, differences in leg extracellular fluid levels between 5:00 pm and 6:00 am, and NUV, but not with diurnal urine volume. Partial correlation coefficients showed that salt intake was a factor of the correlation between NUV and change in extracellular volume in the legs between 5:00 pm and 6:00 am. A multivariate logistic model showed that sleep duration and sodium clearance were independent predictive factors for nocturnal polyuria. Conclusions Sodium intake correlates with diurnal leg edema and NUV in elderly men. These results provide evidence supporting sodium restriction as an effective treatment for nocturnal polyuria.

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Nocturia: aetiology and treatment in adults

Cited by 53 publications

References 137 publications

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Lifestyle habits associated with nocturnal urination frequency: The Nagahama study

Daily salt intake is associated with leg edema and nocturnal urinary volume in elderly men

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