Nocturnal enuresis in sickle cell disease

Wolf, Rachel B.; Kassim, Adetola A.; Goodpaster, R. Lucas; DeBaun, Michael R.

doi:10.1586/17474086.2014.892412

Cited by 34 publications

(32 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early studies demonstrated a dose-dependent relationship between concentration of HbS and degree of hyposthenuria, with individuals with hemoglobin SS or Sβ° genotypes (sickle cell anemia, SCA) demonstrating severely impaired concentrating ability (inability to concentrate urine to >450 mOsm/kg with water deprivation) starting in infancy and those with SCT demonstrating a later onset of impairment usually by age 10 [24]. This impaired ability to concentrate urine starting at a young age is thought to relate to the increased prevalence of nocturnal enuresis among children and adolescents with SCD [25], a phenomenon that may persist into adulthood [26]. …”

Section: Epidemiologymentioning

confidence: 99%

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

Naik

Derebail

2017

Expert Review of Hematology

View full text Add to dashboard Cite

Introduction Renal dysfunction is among the most common complication of sickle cell disease (SCD), from hyposthenuria in children to progression to overt chronic kidney disease (CKD) in young adults. Emerging evidence now suggests that sickle hemoglobin-related nephropathy extends to individuals with sickle cell trait (SCT). Areas covered This review will highlight the pathophysiology, epidemiology, and management recommendations for sickle hemoglobin-related nephropathy in both SCD and SCT. In addition, it will focus on the major demographic and genetic modifiers of renal disease in sickling hemoglobinopathies. Expert commentary Studies have elucidated the course of renal disease in SCD; however, the scope and age of onset of renal dysfunction in SCT has yet to be determined. In SCD, several modifiers of renal disease – such as α-thalassemia, hemoglobin F, APOL1 and HMOX1 – have been described and provide an opportunity for a precision medicine approach to risk stratify patients who may benefit from early intervention. Extrapolating from this literature may also provide insight into the modifiers of renal disease in SCT. Further studies are needed to determine the optimal treatment for sickle hemoglobin-related nephropathy.

show abstract

Section: Epidemiologymentioning

confidence: 99%

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

Naik

Derebail

2017

Expert Review of Hematology

View full text Add to dashboard Cite

show abstract

“…It has been estimated that almost 50 % of children with SCD age 5-10 years and approximately 15 % of adolescents with SCD age 16-20 years suffer from nocturnal enuresis (Wolf et al 2014 ). The etiology of this increased prevalence of nocturnal enuresis is likely multifactorial.…”

Section: Genitourinary Complicationsmentioning

confidence: 99%

Clinical Manifestations of Sickle Cell Anemia: Infants and Children

Nickel

Hsu

2016

Sickle Cell Anemia

View full text Add to dashboard Cite

Children with sickle cell disease (SCD) have varied clinical problems. The hallmark manifestation of SCD, the pain crisis, typically fi rst occurs in early childhood presenting as dactylitis. Pain increases in frequency and severity as children age, especially during adolescence. Due to functional asplenia, children with SCD are at signifi cantly increased risk for certain infections, most notably Streptococcus pneumoniae. Other infections like parvovirus B19 are also special threats and can trigger an aplastic crisis. Unique, potentially life-threatening acute complications like splenic sequestration and acute chest syndrome occur in these children. They are at risk for neurologic disease, the most serious being stroke. In addition, the chronic hemolysis of SCD causes gallstones, which can lead to biliary tract disease. Children with SCD also frequently face chronic issues that include nocturnal enuresis and decreased growth. Despite these many potential problems, with advances in care including antibiotic treatment, stroke screening, blood transfusions, and hydroxyurea therapy, children with SCD rarely die in childhood and can become productive adults.

show abstract

“…Nocturnal enuresis has been defined as the persistence of urination in the bed (bedwetting) at night, two or more times per week after the age of 5 years, for a period of at least 3 months [10]. It can present as a primary form (no previous dry period) or a secondary form (previous dry period), and as monosymptomatic (absence of daytime symptoms) or non-monosymptomatic (presence of daytime symptoms) [9]. Studies which show that children with SCA have a tendency for nocturnal enuresis more than children with normal hemoglobin however reported different prevalence rates and epidemiologic patterns, depending on study methods and definition criteria ( Table 1).…”

Section: Nocturnal Enuresis In Sca: Epidemiologic Perspectivesmentioning

confidence: 99%

“…There are now several hypotheses on the etiopathogenesis of enuresis in children [9,28,29]. In fact, it is believed that children with SCA may have a tendency to develop nocturnal enuresis because of the common general etiopathogenic factors in childhood, SCA-related etiopathogenic factors or a combination of both [9]. Specifically, the unresolved questions include the following: What is the exact Nocturnal Enuresis in Children with Sickle Cell Anemia DOI: http://dx.doi.org/10.5772/intechopen.81578 role of hyposthenuria in SCA-related nocturnal enuresis?…”

Section: Nocturnal Enuresis In Sca: Hypotheses On Etiopathogenesismentioning

confidence: 99%

“…Research on the subject has led to divergent conclusions about the pathogenesis; one report had earlier suggested that hyposthenuria was a major determinant of enuresis in the disease [5], while other authors not only controverted this observation but had reported disparate etiopathogenic factors [6][7][8]. In fact, a recent review of published evidence on the subject indicates similar determinants of nocturnal enuresis for both SCA and non-SCA patients [9]. Thus, the role of hyposthenuria as the exclusive determinant of nocturnal enuresis in children with SCA remains debatable although the consensus is now tilting towards a multifactorial etiopathogenesis in affected children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nocturnal Enuresis in Children with Sickle Cell Anemia

Uwaezuoke¹,

Eneh²,

Ezenwosu³

et al. 2019

Contemporary Pediatric Hematology and Oncology

View full text Add to dashboard Cite

Sickle cell anemia (SCA) is the commonest hemoglobin disorder among the black population worldwide. Children with SCA may eventually end up with end-organ complications: the kidneys being one of the most frequently affected organs. The renal complications arise from medullary ischemia and infarction leading to features of tubular dysfunction such as hyposthenuria and renal tubular acidosis. Early in life, children with SCA may present with hyposthenuria: one of the earliest renal defects in the disease which results in an obligatory urine output of more than 2 l in a day. The symptomatic manifestation as nocturnal polyuria is thought to be the reason for nocturnal enuresis observed in these children. In spite of the more prevalent occurrence of nocturnal enuresis in children with SCA than in their non-SCA colleagues, its precise underlying mechanisms still remain controversial, with divergent conclusions regarding its pathogenesis. However, the consensus is now tilting towards a multifactorial etiopathogenesis in affected children. This book chapter aims to discuss the epidemiologic perspectives of nocturnal enuresis in SCA, as well as the current hypotheses on the etiopathogenesis of this complication.

show abstract

Nocturnal enuresis in sickle cell disease

Cited by 34 publications

References 50 publications

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

Clinical Manifestations of Sickle Cell Anemia: Infants and Children

Nocturnal Enuresis in Children with Sickle Cell Anemia

Contact Info

Product

Resources

About