Nocturnal Plasma Melatonin Profile and Melatonin Kinetics During Infusion in Status Migrainosus

Bruno, Claudio; Brun, Jocelyne; Geoffriau, Martine; Zaidan, Radwan; Mallo, C; Carrault, Guy

doi:10.1046/j.1468-2982.1997.1704511.x

Cited by 55 publications

(33 citation statements)

References 24 publications

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“…In addition, in several recent studies low levels of melatonin were detected in patients suffering from migraine [126]. A phase shift in maximum melatonin levels was observed in 4 of 6 female sufferers of status migrainosus, compared to 9 controls [127]. Finally, a decrease in nocturnal urinary melatonin levels was reported in women suffering from migraine headaches related to their menstrual cycle [128,129].…”

Section: Can Melatonin Be a New Treatment For Migraine Headaches?mentioning

confidence: 88%

Prospects of the Clinical Utilization of Melatonin

Bubenik

Blask

Brown

et al. 1998

Biol Signals Recept

130

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This review summarizes the present knowledge on melatonin in several areas on physiology and discusses various prospects of its clinical utilization. Ever increasing evidence indicates that melatonin has an immuno-hematopoietic role. In animal studies, melatonin provided protection against gram-negative septic shock, prevented stress-induced immunodepression, and restored immune function after a hemorrhagic shock. In human studies, melatonin amplified the antitumoral activity of interleukin-2. Melatonin has been proven as a powerful cytostatic drug in vitro as well as in vivo. In the human clinical field, melatonin appears to be a promising agent either as a diagnostic or prognostic marker of neoplastic diseases or as a compound used either alone or in combination with the standard cancer treatment. Utilization of melatonin for treatment of rhythm disorders, such as those manifested in jet lag, shift work or blindness, is one of the oldest and the most successful clinical application of this chemical. Low doses of melatonin applied in controlled-release preparation were very effective in improving the sleep latency, increasing the sleep efficiency and rising sleep quality scores in elderly, melatonin-deficient insomniacs. In the cardiovascular system, melatonin seems to regulate the tone of cerebral arteries; melatonin receptors in vascular beds appear to participate in the regulation of body temperature. Heat loss may be the principal mechanism in the initiation of sleepiness caused by melatonin. The role of melatonin in the development of migraine headaches is at present uncertain but more research could result in new ways of treatment. Melatonin is the major messenger of light-dependent periodicity, implicated in the seasonal reproduction of animals and pubertal development in humans. Multiple receptor sites detected in brain and gonadal tissues of birds and mammals of both sexes indicate that melatonin exerts a direct effect on the vertebrate reproductive organs. In a clinical study, melatonin has been used successfully as an effective female contraceptive with little side effects. Melatonin is one of the most powerful scavengers of free radicals. Because it easily penetrates the blood-brain barrier, this antioxidant may, in the future, be used for the treatment of Alzheimer’s and Parkinson’s diseases, stroke, nitric oxide, neurotoxicity and hyperbaric oxygen exposure. In the digestive tract, melatonin reduced the incidence and severity of gastric ulcers and prevented severe symptoms of colitis, such as mucosal lesions and diarrhea.

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Section: Can Melatonin Be a New Treatment For Migraine Headaches?mentioning

confidence: 88%

Prospects of the Clinical Utilization of Melatonin

Bubenik

Blask

Brown

et al. 1998

Biol Signals Recept

130

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“…Имеются данные [31] об использовании мелатонина в терапии мигрени. Его применение у 4 из 6 пациентов при-вело к уменьшению интенсивности головной боли по утрам уже после 1-го приема, а остальные 2 пациента ис-пытали это облегчение после 3-й дозы препарата; 3 паци-ента констатировали исчезновение пульсирующего ха-рактера боли.…”

Section: Discussionunclassified

A role of melatonin in the treatment of low back pain

Kurganova¹,

Данилов²

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…These include several forms of cardiac diseases (coronary heart disease, myocardial infarction, cardiac syndrome X) [149–155], fibromyalgia [125,156], neuralgia [156], migraine [157,158], severe epilepsy [159,160], Menière’s disease [161], bulimia [156], critical illness [162–164], postoperative stress [165], acute intermittent porphyria, especially during seizures [166,167], and cases of cancer [168,169]. …”

Section: Melatonin Dysfunctionmentioning

confidence: 99%

Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus—Consequences to Melatonin Dysfunction

Hardeland

2013

IJMS

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The mammalian circadian system is composed of numerous oscillators, which gradually differ with regard to their dependence on the pacemaker, the suprachiasmatic nucleus (SCN). Actions of melatonin on extra-SCN oscillators represent an emerging field. Melatonin receptors are widely expressed in numerous peripheral and central nervous tissues. Therefore, the circadian rhythm of circulating, pineal-derived melatonin can have profound consequences for the temporal organization of almost all organs, without necessarily involving the melatonin feedback to the suprachiasmatic nucleus. Experiments with melatonin-deficient mouse strains, pinealectomized animals and melatonin receptor knockouts, as well as phase-shifting experiments with explants, reveal a chronobiological role of melatonin in various tissues. In addition to directly steering melatonin-regulated gene expression, the pineal hormone is required for the rhythmic expression of circadian oscillator genes in peripheral organs and to enhance the coupling of parallel oscillators within the same tissue. It exerts additional effects by modulating the secretion of other hormones. The importance of melatonin for numerous organs is underlined by the association of various diseases with gene polymorphisms concerning melatonin receptors and the melatonin biosynthetic pathway. The possibilities and limits of melatonergic treatment are discussed with regard to reductions of melatonin during aging and in various diseases.

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Nocturnal Plasma Melatonin Profile and Melatonin Kinetics During Infusion in Status Migrainosus

Cited by 55 publications

References 24 publications

Prospects of the Clinical Utilization of Melatonin

Prospects of the Clinical Utilization of Melatonin

A role of melatonin in the treatment of low back pain

Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus—Consequences to Melatonin Dysfunction

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