Nodular glomerulosclerosis and renin angiotensin system in Chinese patients with type 2 diabetes

Wang, Min; Zhang, Xiaoxi; Song, Xin-Nan; Zou, Xia; Wu, Wenyan; Wang, Yanchao; Lin, Bing-Jie; Li, Rong; Hu, Fang; Zhao, Hai-Lu

doi:10.1016/j.mce.2016.03.008

Cited by 9 publications

(17 citation statements)

References 45 publications

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“…Wang et al . [34] have recently demonstrated an association between the D allele (rs4340) and glomerular filtration impairment in Chinese patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Šeruga

Makuc

Završnik

et al. 2016

Balkan Journal of Medical Genetics

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Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ2 test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group (p <0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the ACE gene and DN in Caucasian patients who have T2DM.

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“…Wang et al . [34] have recently demonstrated an association between the D allele (rs4340) and glomerular filtration impairment in Chinese patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Šeruga

Makuc

Završnik

et al. 2016

Balkan Journal of Medical Genetics

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“…Patients were subjected to detailed eye examination with ophthalmoscopy and funduscopy and fundus photography to assess retinopathy. In addition to a thorough physical examination, we examined the following variables for each patient: body mass index (BMI), fasting plasma glucose (FPG), glycated haemoglobin (HbA 1c ), lipid profile (triglyceride [TG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], and low-density lipoprotein cholesterol [LDL-C]), albumin creatinine ratio (ACR) and albumin excretion rate (AER), as described in our previous report [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…Most of the work focused on the role of RAS in T2DM patients, but few efforts devote to the pathogenesis of T1DM about insulin resistance in clinical studies. Our previous works have proved that an association exists between diabetic glomerulosclerosis with immunoreactivity and RAS gene polymorphisms [ 13 ]. Hereby, we explore the interaction of ACE and AGT gene polymorphisms with known risk factors such as hypertension for the development of DR in Chinese T1DM patients.…”

Section: Introductionmentioning

confidence: 99%

Interaction of renin-angiotensin system gene polymorphisms with hypertension in Chinese patients with type 1 diabetes and retinopathy

Qiao

Xu²,

Zhang

et al. 2018

Oncotarget

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BackgroundThe objective of this research was to investigate the interaction of RAS gene polymorphisms in Chinese patients with type 1 diabetes mellitus (T1DM) and diabetic retinopathy (DR).MethodsGenomic DNA was extracted from peripheral blood leukocytes and genotyping for the angiotensin converting enzyme (ACE) gene I/D and angiotensinogen (AGT) gene M/T polymorphisms was performed using the polymerase chain reaction method. 311 T1DM patients were recruited for the assessment of ACE and AGT polymorphisms relating to DR.ResultsCompared with the diabetic non-retinopathy (DNR) patients, DR patients had lower proportion of diabetic nephropathy (p<0.001) and M allele (p=0.013). Intriguingly, the frequency D allele (p=0.035) was lower in DR patients with hypertension, as well as DD (p=0.003) and DI genotype (p=0.012) in DR patients with normal blood pressure after multiple tests with Bonferroni correction, but D allele (p=0.025) displayed higher in normotensive patients with T1DM. Logistic regression analyses indicated that no significant relationship existed about the genotype and allele polymorphisms with the progress of DR after adjusting for confounding factors.ConclusionsInteraction of hypertension and the RAS gene polymorphisms might have a role in the DR development in Chinese T1DM patients.

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“…Genomic DNA was isolated from peripheral blood that collected on ethylene diaminetetra acetic acid using standard phenol/chloroform methods. [ 15 ] PCR was used to genotype for RAS gene polymorphisms including ACE gene insertion/deletion (I/D) polymorphisms and AGT gene M/T polymorphisms as prior described. [ 16 ] Primers for the ACE I/D polymorphisms were 5′-CTGGAGACCACTCCCATCCTTTCT-3′ and 5′-GATGTGGCCATCACATTCGTCAGAT-3′, at the annealing temperature of 58°C, subsequently following by a second insertion specific PCR to avoid DD/ID mistyping using another pair of primers, 5′-TGGGACCACAGCGCCCGCCACTAC-3′ and 5′-TCGCCAGCCCTCCCATGCCCATAA-3′, at the annealing temperature of 67 °C.…”

Section: Methodsmentioning

confidence: 99%

Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus

et al. 2017

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Nodular glomerulosclerosis and renin angiotensin system in Chinese patients with type 2 diabetes

Cited by 9 publications

References 45 publications

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

Interaction of renin-angiotensin system gene polymorphisms with hypertension in Chinese patients with type 1 diabetes and retinopathy

Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus

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