Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Hanich, Toni; Majnarić, Ljiljana Trtica; Janković, Dragan; Šabanović, Šefket; Včev, Aleksandar

doi:10.1016/j.ijscr.2016.11.033

Cited by 5 publications

(4 citation statements)

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“…In individuals with immunode ciency syndrome, there was a correlation between intestine lymphoma and NHL. In a case report, NHL and ileal Burkitt's lymphoma were present together, supporting the theory that NLH exists between immunode ciency and intestinal lymphoma 9 .…”

Section: Discussionsupporting

confidence: 59%

Nodular lymphoid hyperplasia, a rare case report

Liu

Zhang

et al. 2023

Preprint

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Background: A rare immune-deficient condition is known as nodular lymphoid hyperplasia (NLH). It is not known how common it is, but gene-molecular testing in conjunction with a medical history may definitively identify it. Case summary: A 28-year-old man who had been seeking medical care for sporadic stomach pain throughout the previous years was described in the case. Colonoscopy showed 2 to 4 mm-diameter diffuse nodular hyperplasia of the rectum and ileum mucosa. The Lamina propria had a significant infiltration of lymphocytic inflammatory cells, according to ileal and rectal biopsies.To 0.01g/L, the immunoglobulin A level had drastically dropped.Finally, supplementary testing in conjunction with a whole gene exon test was used to determine the diagnosis of nodular lymphoid histiocytosis. Regular follow-up testing is necessary since this case runs the risk of developing into intestinal lymphoma. Conclusion: This example highlights the fact that abdominal discomfort is a frequent clinical symptom that can be caused by a variety of different conditions, and while NLH is an uncommon disease, doctors are advised not to dismiss it when it is present.

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Section: Discussionsupporting

confidence: 59%

Nodular lymphoid hyperplasia, a rare case report

Liu

Zhang

et al. 2023

Preprint

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“…9 Although there is no specific treatment, when discovered in the setting of G lamblia or Helicobacter pylori , eradication of the infection leads to regression of lymphoid nodules. Persistent NLH necessitates small bowel endoscopy with biopsy because NLH has been linked to lymphomas, usually B-cell tumors, 10 and gastric carcinomas. 11…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders

Agarwal

Cunningham‐Rundles

2019

Immunology and Allergy Clinics of North America

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SUMMARY Although the hallmark of PIDs is increased susceptibility to infection, many are associated with and initially present with GI diseases, making routine evaluation of the gut necessary. A history of recurrent infections, clinical and/or histologic features atypical of the usual pattern of GI disease, or a poor response to conventional therapy should prompt further immunologic evaluation. Early diagnosis and treatment may prevent irreversible tissue damage and mortality. In most cases, treatment with replacement immunoglobulin and antibiotics does not reverse or prevent the development of GI disease; therefore, additional immunomodulatory therapies, including, in some cases, organ transplantation, are indicated.

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“…при анализе 1150 колоноскопий выявили узелковую лимфоидную гиперплазию в 3 % случаев у бессимптомных лиц (скрининг колоректального рака) и в 32 % у пациентов с «кишечными» жалобами [20]. Узелковая лимфоидная гиперплазия наблюдается у 20 % пациентов с общим вариабельным иммунодефицитом [14-16, 21, 22] и часто встречается при селективном дефиците IgA [3,4,16,23,24].…”

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“…Рецидивирующую инфекцию C. difficile, которая разрешилась после курса ванкомицина, при селективном дефиците IgA, мы также относим к особенностям клинического случая. Следует подчеркнуть важность распознавания узелковой лимфоидной гиперплазии, которую как при сочетании с иммунодефицитными состояниями, так и изолированно ряд авторов считает фактором риска интестинальных и экстраинтестинальных лимфом, аденокарциномы желудка и колоректального рака [3,16,[23][24][25].…”

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A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency

Gonik

Щербаха²,

Юрьева

et al. 2019

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. To present a clinical case with differential diagnosis of the cause of diarrhea in a patient with selective IgA deficiency.Key findings. A 46-year-old woman complained of a mushy stool without pathological impurities up to 5 times a day. An outpatient colonoscopy revealed signs of terminal ileitis. The patient’s medical history included selective IgA and vitamin B12 deficiency. Despite the absence of antibodies to parietal cells and intrinsic factor, a diagnosis of autoimmune gastritis was established on the basis of histologically confirmed atrophy of the stomach; decrease in serum pepsinogen I and the ratio of pepsinogen I to pepsinogen II, hypergastrinemia; vitamin B12 deficiency; proven autoimmune thyroiditis (antibodies to thyroglobulin and thyroid peroxidase in the diagnostic titre). Histologically, lymphoid hyperplasia of the stomach was determined. Colonoscopy revealed erosive terminal ileitis and colitis, as well as an increase in the lymphoid follicles of the sub-mucosal layer in the ileum and all parts of the colon, which gave a rough pattern to the mucosa. Histological examination revealed pronounced follicular hyperplasia of the lymphoid tissue of the ileum and colon. The clinical diagnosis was established as follows. The combined main disease: 1. Selective IgA deficiency with a nodular lymphoid hyperplasia of the stomach, small and large intestine. 2. Autoimmune gastritis with erosions in the gastric fornix. Vitamin B12 deficiency. Concomitant diseases: Autoimmune thyroiditis.Conclusion. The presented clinical observation demonstrates the importance of recognizing nodular lymphoid hyperplasia, which is established as the cause of diarrhea in a patient with selective IgA deficiency after excluding the diagnosis of Crohn’s disease. A specific feature of the presented clinical case is a combination of autoimmune gastritis and autoimmune thyroiditis with selective IgA deficiency.

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Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Abstract: HighlightsBurkitt's lymphoma in adults can occur on the basis of nodular lymphoid hyperplasia.Nodular lymphoid hyperplasia is associated with selective IgA deficiency.Nodular lymphoid hyperplasia associates IgA deficiency with Burkitt's lymphoma.

Cited by 5 publications

References 18 publications

Nodular lymphoid hyperplasia, a rare case report

Nodular lymphoid hyperplasia, a rare case report

Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders

A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency

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