Nodular lymphoid hyperplasia of the small intestine with Burkitt's lymphoma and dysgammaglobulinemia

Schaefer, Paul S.; Friedman, Arnold C.

doi:10.1007/bf01890278

Cited by 9 publications

(3 citation statements)

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“…This case report is one of the first presenting a rare combination of BL of the ileum and nodular lymphoid hyperplasia (NLH), probably due to selective IgA deficiency [5]. NLH is a condition characterized with numerous small nodules diffusely distributed along the segments of the GI tract, histologically evaluated as reactive follicular hyperplasia [6].…”

Section: Introductionmentioning

confidence: 98%

Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Hanich

Majnarić

Janković

et al. 2017

International Journal of Surgery Case Reports

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Section: Introductionmentioning

confidence: 98%

Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Hanich

Majnarić

Janković

et al. 2017

International Journal of Surgery Case Reports

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“…7,8 There are also some reports that the lesion can be a risk factor for intestinal lymphoma or, very rarely, for extraintestinal lymphoma. [9][10][11][12][13][14][15][16][17][18][19][20] Therefore, since lymphoid hyperplasia may indicate risks for lymphoma, some researchers recommend surveillance of the lesion. 21 However, no guideline has been established for the follow-up and management on the lesion.…”

Section: Introductionmentioning

confidence: 99%

Long-term Prognosis of Localized Lymphoid Hyperplasia of the Rectum

Hong

Kim

et al. 2021

Gut and Liver

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Background/Aims: Although localized lymphoid hyperplasia (LLH) of the rectum is occasionally observed, its clinical implications are unclear. This study aimed to investigate the clinical course and significance of LLH of the rectum. Methods: We identified 65 patients diagnosed with LLH of the rectum using a histopathologic examination and who received follow-up endoscopies between January 2009 and June 2015. Patients with a history of inflammatory bowel disease, lymphoma, familial adenomatous polyposis, or uncontrolled malignancy and patients who underwent scar biopsy after endoscopic resection or surgery were excluded. Endoscopic findings and clinical courses were analyzed. Results: During the median follow-up of 31 months (interquartile range, 19 to 40 months), 81.5% (53/65) of LLHs of the rectum were resolved. Clinically significant diseases, including ulcerative colitis (UC, n=5) and mucosa-associated lymphoid tissue (MALT) lymphoma (n=1), were diagnosed in 9.2% of patients (6/65). The other six patients showed no significant changes in the lesion (n=3) or a waxing and waning appearance (n=3). According to endoscopic findings, all of the 47 polypoid types showed resolution or waxing and waning patterns. Five of the 11 nodular types (45.5%) developed into UC. One of the seven submucosal tumor (SMT)-like types (14.3%) developed into MALT lymphoma. Conclusions: LLH of the rectum with persistent symptoms or the endoscopic appearance of the nodular or SMT-like type may lead to clinically significant disease. Risk stratification according to endoscopic findings and careful surveillance are required for these lesions.

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“…La hiperplasia nodular linfoide se considera un factor de riesgo para el desarrollo de linfoma intestinal (28,29) y extraintestinal (30,31), adenomas y carcinomas (32), por lo que algunos autores recomiendan series baritadas y cápsulas endoscópicas seriadas (24), aunque la duración y los intervalos de dicha vigilancia no están definidos (15). No existen estudios previos que evalúen la validez diagnóstica del hallazgo de nódulos durante la colonoscopia al compararlo con la histología en el diagnóstico de hiperplasia nodular linfoide.…”

Section: Introductionunclassified

Validez del hallazgo de nódulos en la colonoscopia para el diagnóstico de hiperplasia nodular linfoide en niños

Sempértegui-Cárdenas

Cadena-León

Arellano

et al. 2021

Rev colomb Gastroenterol

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Introducción: la hiperplasia nodular linfoide del colon se define como > 10 nódulos linfoides visibles en colonoscopia. No existen estudios de su validez al compararlo con la histopatología. Objetivos: determinar la validez del hallazgo de nódulos en colonoscopia para el diagnóstico de hiperplasia nodular linfoide. Material y métodos: estudio prospectivo de prueba diagnóstica. Se incluyeron colonoscopias realizadas consecutivamente de 2014 al 2018 con equipos Olympus PCFQ150AI y GIFXP150N con obtención de biopsias. El criterio endoscópico fue la presencia de > 10 nódulos de 2 a 10 mm y el criterio histológico fue hiperplasia de folículos linfoides y mantos de linfocitos en lámina propia o submucosa. Los datos se analizaron en Epidat3.1. Se obtuvo la sensibilidad (S), especificidad (E), valor predictivo positivo (VPP) y negativo (VPN), y coeficientes de probabilidad positivo (LR+) y negativo (LR-) con sus intervalos de confianza. Resultados: se incluyeron 327 colonoscopias, la mediana de edad fue de 84 meses. La principal indicación para la colonoscopia fue sangrado digestivo bajo (38,8 %). El hallazgo de nódulos se encontró en el 21 % y el sitio de mayor frecuencia fue el colon total (46 %), mientras que por histopatología se encontró hiperplasia nodular linfoide en el 38 %. El hallazgo de nódulos obtuvo una S de 32 % (intervalo de confianza [IC] del 95 %: 24-140), E de 84 % (IC 95 %: 79-89), VPP de 56 % (IC 95 %: 44-68), VPN de 67 % (IC 95 %: 61-72), LR+ de 2,04 (IC 95 %: 1,4-3) y LR- de 0,8 (IC 95 %: 0,8-0,9). Conclusiones: la validez diagnóstica del hallazgo de nódulos en colonoscopia para hiperplasia nodular linfoide es pobre, por lo que la toma de biopsia debe recomendarse siempre.

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Nodular lymphoid hyperplasia of the small intestine with Burkitt's lymphoma and dysgammaglobulinemia

Abstract: An unusual case of American Burkitt's lymphoma of the jejunum complicating diffuse nodular lymphoid hyperplasia of the small bowel is reported. The radiological and pathological findings are correlated and the pertinent literature is reviewed.

Cited by 9 publications

References 10 publications

Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Nodular lymphoid hyperplasia complicated with ileal Burkitt's lymphoma in an adult patient with selective IgA deficiency

Long-term Prognosis of Localized Lymphoid Hyperplasia of the Rectum

Validez del hallazgo de nódulos en la colonoscopia para el diagnóstico de hiperplasia nodular linfoide en niños

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