Nogo-B receptor is required for stabilizing TGF-β type Ireceptor and promotes the TGF-β1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer

Chrysin Modulates Aberrant Epigenetic Variations and Hampers Migratory Behavior of Human Cervical (HeLa) Cells

“…Matrix metalloproteinases are important proteolytic enzymes involved in the cancer cell invasion process. Epithelial mesenchymal transition (EMT) increases cell migration, and the transforming growth factor pathway has an important role to play in epithelial mesenchymal transition; it induces EMT either by transforming growth factor-β (TGF-β)/SMAD pathway or via the non-SMAD pathway by activating the AKT/PI3K pathway, thus triggering migration ( Wu et al, 2021 ; Xue et al, 2012 ). The downregulation of TGF-β/SMAD mediates reduction in the expression of MMPS and TWIST1 ( Wu et al, 2021 ; Xue et al, 2012 ; Baruah et al, 2016 ).…”

“…Epithelial mesenchymal transition (EMT) increases cell migration, and the transforming growth factor pathway has an important role to play in epithelial mesenchymal transition; it induces EMT either by transforming growth factor-β (TGF-β)/SMAD pathway or via the non-SMAD pathway by activating the AKT/PI3K pathway, thus triggering migration ( Wu et al, 2021 ; Xue et al, 2012 ). The downregulation of TGF-β/SMAD mediates reduction in the expression of MMPS and TWIST1 ( Wu et al, 2021 ; Xue et al, 2012 ; Baruah et al, 2016 ). Cadherins are a class of type-1 transmembrane proteins that maintain the adhesion between cells, their loss lead to invasion and metastasis, and snails are their inhibitors.…”

“…Cadherins are a class of type-1 transmembrane proteins that maintain the adhesion between cells, their loss lead to invasion and metastasis, and snails are their inhibitors. MTA1 and MTA2 are metastasis promoters, and their reduction leads to the inhibition of metastasis ( Wu et al, 2021 ; Xue et al, 2012 ; Baruah et al, 2016 ). In the study, chrysin-mediated inhibition of migration was found to be well correlated with the downregulation of metalloproteases MMP 9 , MMP 2 , and MMP 14 and their co-operators like SMAD3 , SMAD4 , SNAIL1 , SNAIL2 , MTA1 , and MTA2 , and upregulation of their inhibitors like TIMP3 , TIMP4 , and CDH1 , hence endorsing the inhibitory effect of chrysin on migration.…”

Activatable “Matryoshka” nanosystem delivery NgBR siRNA and control drug release for stepwise therapy and evaluate drug resistance cancer

“…Subsequently, researchers have found that ERα-positive breast cancer patients have a poor response to various chemotherapy drugs such as paclitaxel and anthracyclines. A large amount of evidence points out that estrogen and ERα interact with various signaling pathways such as human neuroglobin (NGB) [ 17 ], transforming growth factor (TGF)-β [ 18 ], P53 [ 19 ] to promote proliferation, inhibiting apoptosis, stimulating metastasis [ 20 ], and angiogenesis [ 21 ] while triggering the drug resistance of tumor cells [ 2 , 22 , 23 ]. Due to the high morbidity and mortality of ERα-positive breast cancer, early recognition of drug resistant tumors and personalized treatment is vital.…”

“…NgBR was first reported by Miao's team [ 26 ], it is a type I receptor with a single transmembrane domain and the specific receptor for Nogo-B. It is highly expressed in a variety of cancer and proliferating vascular endothelial cells [ 18 , [27] , [28] , [29] ], which have aroused the extensive interest of researchers as soon as they were proposed. NgBR is involved in various disease processes, including diabetes [ 30 ], hemangioma [ 28 ], inflammation [ 31 ], and is involved in the occurrence and development of tumors.…”