Noise heterogeneity in attenuation-corrected cardiac SPECT images increases perfusion value uncertainty near the base of the heart

Quantitative analysis: Specific normal database for the best practice

“…In this issue of the Journal, Cuddy-Walsh et al evaluated if this variation of sensitivity and the spatial gradients will lead to gradients in image noise within the FOV and if there is impact in the efficacy of visual and quantitative image interpretation with a normal database. 4 Also, it was analyzed if the heterogeneous attenuation of different regions of the heart increases the noise gradient in multi-pinhole camera images and introduces a noise gradient in parallel-hole camera images. These effects could impact the clinical sensitivity of disease detection for different areas of the heart.…”