“…Continuous positive airway pressure (CPAP) has become the preferred mode of respiratory support in this population, however CPAP devices generate noise levels significantly above current recommendations [1,8,9,10]. In recent years, the use of high-flow nasal cannula (HFNC) devices gained increased popularity in NICUs as an alternative non-invasive ventilation (NIV) modality post-extubation, as primary treatment of apnea of prematurity and respiratory distress syndrome, or to wean neonates from CPAP, despite a lack of supporting data from large prospective trials [11,12].…”