Noise-Stress-Induced Brain Neurotransmitter Changes and the Effect of Ocimum sanctum (Linn) Treatment in Albino Rats

Rajan, Ramesh; Devi, Rathinasamy Sheela; Samson, J.; Senthilvelan, M

doi:10.1254/jphs.fp0050127

Cited by 109 publications

(81 citation statements)

References 17 publications

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“…Noise exposure exceeds 90 dB has been reported to be a source of stressor [4]. The adverse impact of noise on learning, memory and hippocampal neurogenesis has been reported by previous studies [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 72%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 72%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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“…Moreover, alterations in brain monoamine neurotransmitter release are associated with brain injury and cognitive impairment 27) . Acute or sub-chronic noise exposures were both found to change the level of biogenic amines in discrete regions of the rat brain 17,26) . Our results demonstrat that the levels of DA, NE and 5-HT were significantly decreased in the hippocampi of young male rats after noise exposure (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…LM is coordinated among different brain regions, especially the hippocampus and the medial prefrontal cortex 12,15,16) . In Ravindran's study, rats were subjected to 100 dB broadband white noise for 15 days, which was found to alter the biogenic amine levels in discrete regions of the rat brain 17) . However, to date, there is very little information about the noiseinduced changes of monoamine neurotransmitter levels in the hippocampus and there are no studies on long-term monoamine level alterations after noise exposure in the literature.…”

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confidence: 99%

Recovery of Chronic Noise Exposure Induced Spatial Learning and Memory Deficits in Young Male Sprague‐Dawley Rats

Chen

Yan

Jiang

et al. 2011

Journal of Occupational Health

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Objective: Noise has always been an important environmental public health issue for mankind. Although reports exist on hippocampaldependent spatial learning and memory (LM) impairment due to noise, there are only a few studies that have examined the effects of recovery from noise stress on LM impairments. Therefore, the present study investigated the effects of recovery from chronic noise exposure on LM deficits. Materials and Methods: In this study, the detrimental effects of noise stress on young male rats in the Morris water maze (MWM) were investigated at 1, 10, 20, 30, and 40 days after the discontinuation of chronic noise exposure of 80 dB or 100 dB for 4 h per day, for 30 days. The levels of monoamine neurotransmitters in the hippocampus were also evaluated by HPLC-EC at the end of each behavioral test. Results: Statistical analysis revealed that rats in the noise-treated groups failed to reach the same level of performance as the controls in the MWM. Further, the levels of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT) were significantly decreased in the hippocampus after noise exposure. However, the reduction in monoamine levels and impaired water maze performance recovered over time, so that by 30th day after cessation of noise exposure the 80 dB group showed no performance difference from the controls, and by 40th day, the 100 dB group also showed no performance difference from the control. Conclusion:Our findings suggest that noise impaired LM in young male rats and reduced monoamine neurotransmitters in the hippocampus. However, the noise-induced water maze deficits recovered over time, and the concurrent restoration of hippocampal monoamine neurotransmitter levels suggest that they are involved in LM impairments. (J Occup Health 2011; 53: 157-163)

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“…The noise can be set at a certain level (e.g., 100 dB or higher) and the animals can be exposed to the noise protocol either acutely or repeatedly (4 hours/day/15 days). 113,114 Like those of other protocols, the behavioral effects of noise stress can be observed in animal models of anxiety and depression.…”

Section: -112mentioning

confidence: 99%

Animal models of anxiety disorders and stress

Campos

Fogaça

Aguiar

et al. 2013

Rev. Bras. Psiquiatr.

378

246

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Anxiety and stress-related disorders are severe psychiatric conditions that affect performance in daily tasks and represent a high cost to public health. The initial observation of Charles Darwin that animals and human beings share similar characteristics in the expression of emotion raise the possibility of studying the mechanisms of psychiatric disorders in other mammals (mainly rodents). The development of animal models of anxiety and stress has helped to identify the pharmacological mechanisms and potential clinical effects of several drugs. Animal models of anxiety are based on conflict situations that can generate opposite motivational states induced by approach-avoidance situations. The present review revisited the main rodent models of anxiety and stress responses used worldwide. Here we defined as ''ethological'' the tests that assess unlearned/unpunished responses (such as the elevated plus maze, light-dark box, and open field), whereas models that involve learned/ punished responses are referred to as ''conditioned operant conflict tests'' (such as the Vogel conflict test). We also discussed models that involve mainly classical conditioning tests (fear conditioning). Finally, we addressed the main protocols used to induce stress responses in rodents, including psychosocial (social defeat and neonatal isolation stress), physical (restraint stress), and chronic unpredictable stress.

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Noise-Stress-Induced Brain Neurotransmitter Changes and the Effect of Ocimum sanctum (Linn) Treatment in Albino Rats

Cited by 109 publications

References 17 publications

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Recovery of Chronic Noise Exposure Induced Spatial Learning and Memory Deficits in Young Male Sprague‐Dawley Rats

Animal models of anxiety disorders and stress

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