Nomenclature for factors of the swine leukocyte antigen class II system, 2005

Smith, Douglas M.; Lunney, Joan K.; Ho, Chak Sum; Martens, Gregory W.; Andõ, Akira; Lee, J. H.; Schook, Lawrence B.; Renard, Christine; Chardon, Patrick

doi:10.1111/j.1399-0039.2005.00492.x

Cited by 88 publications

(66 citation statements)

References 56 publications

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“…The nucleotide sequences of SLA-1 *rh03 (AF074427), SLA-2 *05rh03 (AF074428), DRB1 *06sL47 (L08847), DQB1 *0203 (AB012093, AF113970), and DQB1 *0204 (L08844, EU039916) had previously been submitted to the IPD-MHC database and were identical to the partial coding sequences (exons 2 and 3 of SLA class I genes and exon 2 of class II genes) that we identified in SPF Yorkshire and Landrace pigs. Therefore, the official allele names were assigned as follows by the committee, according to the SLA nomenclature rules (22–24): SLA-1 *07:03 (KU754555), SLA-2 *05:05 (KU754569), DRB1 *06:07 (KU754601), DQB1 *02:03 (KU754591), and DQB1 *02:12 (KU754590), respectively. The other official allele designations assigned by the ISAG SLA Nomenclature Committee are shown in Table S2 in Supplementary Material.…”

Section: Resultsmentioning

confidence: 99%

Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs

et al. 2017

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The highly polymorphic swine major histocompatibility complex (MHC), termed swine leukocyte antigen (SLA), is associated with different levels of immunologic responses to infectious diseases, vaccines, and transplantation. Pig breeds with known SLA haplotypes are important genetic resources for biomedical research. Canadian Yorkshire and Landrace pigs represent the current specific pathogen-free (SPF) breeding stock maintained in the isolation environment at the Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences. In this study, we identified 61 alleles at five polymorphic SLA loci (SLA-1, SLA-2, SLA-3, DRB1, and DQB1) representing 17 class I haplotypes and 11 class II haplotypes using reverse transcription-polymerase chain reaction (RT-PCR) sequence-based typing and PCR-sequence specific primers methods in 367 Canadian SPF Yorkshire and Landrace pigs. The official designation of the alleles has been assigned by the SLA Nomenclature Committee of the International Society for Animal Genetics and released in updated Immuno Polymorphism Database-MHC SLA sequence database [Release 2.0.0.3 (2016-11-03)]. The submissions confirmed some unassigned alleles and standardized nomenclatures of many previously unconfirmed alleles in the GenBank database. Three class I haplotypes, Hp-37.0, 63.0, and 73.0, appeared to be novel and have not previously been reported in other pig populations. One crossover within the class I region and two between class I and class II regions were observed, resulting in three new recombinant haplotypes. The presence of the duplicated SLA-1 locus was confirmed in three class I haplotypes Hp-28.0, Hp-35.0, and Hp-63.0. Furthermore, we also analyzed the functional diversities of 19 identified frequent SLA class I molecules in this study and confirmed the existence of four supertypes using the MHCcluster method. These results will be useful for studying the adaptive immune response and immunological phenotypic differences in pigs, screening potential T-cell epitopes, and further developing the more effective vaccines.

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Section: Resultsmentioning

confidence: 99%

Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs

et al. 2017

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“…Since the first version, we have been able to add sequences from cattle (BoLA) (17), teleost fish (28), rats (RT1) (29), sheep (OLA) (15) and swine (SLA) (14). In 2012, the nomenclature used to describe the alleles of NHP was extensively revised and updated (16).…”

Section: Introductionmentioning

confidence: 99%

IPD—the Immuno Polymorphism Database

Robinson

Halliwell

McWilliam

et al. 2012

Nucleic Acids Research

239

130

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The Immuno Polymorphism Database (IPD), http://www.ebi.ac.uk/ipd/ is a set of specialist databases related to the study of polymorphic genes in the immune system. The IPD project works with specialist groups or nomenclature committees who provide and curate individual sections before they are submitted to IPD for online publication. The IPD project stores all the data in a set of related databases. IPD currently consists of four databases: IPD-KIR, contains the allelic sequences of killer-cell immunoglobulin-like receptors, IPD-MHC, a database of sequences of the major histocompatibility complex of different species; IPD-HPA, alloantigens expressed only on platelets; and IPD-ESTDAB, which provides access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines. The data is currently available online from the website and FTP directory. This article describes the latest updates and additional tools added to the IPD project.

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“…The SLA class II region has been fully sequenced [51,151,198]. The SLA class II genes demonstrate high strong sequence homology with their human leukocyte antigen (HLA) counterparts.…”

Section: Major Histocompatibility Complex Class IImentioning

confidence: 99%

Membrane markers of the immune cells in swine: an update

Piriou-Guzylack¹,

2008

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-Besides their breeding value, swine are increasingly used as biomedical models. As reported in three international swine clusters of differentiation (CD) workshops and in the animal homologue section of the last workshop for the determination of human leukocyte differentiation antigens (HLDA 8), characterisation of leukocyte surface antigens by monoclonal antibodies and other molecular studies have determined the cell lineages and blood leukocyte subsets implicated in the immune response, including cell adhesion molecules involved in cell trafficking. This review focusses on the current state of knowledge of porcine leukocyte differentiation and major histocompatibility complex (SLA) molecules. Examples of porcine particularities such as the double-positive T lymphocytes with the phenotype CD4 + CD8 low and CD4 − CD8 low T cell subsets and the persistence of SLA class II after T-lymphocyte activation are illustrated, as well as the shared characteristics of the Artiodactyla group, such as the high proportion of TcR (T cell receptor) T cells in blood and other lymphoid tissues. Furthermore, discrepancies between swine and humans, such as CD16 expression on dendritic cells and CD11b (wCD11R1) tissue distribution are outlined. The rapidly growing information should facilitate manipulation of the swine immune system towards improving disease control, and open new avenues for biomedical research using the pig as a model. cluster of differentiation (CD) / monoclonal antibody / immune system / histocompatibility system / pig

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Nomenclature for factors of the swine leukocyte antigen class II system, 2005

Abstract: A systematic nomenclature for the genes and alleles of the swine major histocompatibility complex (MHC) is essential to the development and communication of research in swine immunology.

Cited by 88 publications

References 56 publications

Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs

Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen-Free Yorkshire and Landrace Pigs

IPD—the Immuno Polymorphism Database

Membrane markers of the immune cells in swine: an update

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