Nomogram Predictive of Cancer Specific Survival in Patients Undergoing Partial or Total Amputation for Squamous Cell Carcinoma of the Penis

Kattan, Michael W.; Ficarra, Vincenzo; Artibani, Walter; Cunico, S. Cosciani; Fandella, A.; Martignoni, Guido; Novara, Giacomo; Galetti, T. Prayer; Zattoni, Filiberto

doi:10.1016/s0022-5347(06)00313-2

Cited by 104 publications

(70 citation statements)

References 15 publications

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“…Stage and grade represent established predictors of CSM (11,20,22,23). However, until recently, no prognostic model allowed to rely on the combined effects of these two predictors to provide individual estimates of CSM after removal of PPSCC.…”

Section: Discussionmentioning

confidence: 99%

“…However, until recently, no prognostic model allowed to rely on the combined effects of these two predictors to provide individual estimates of CSM after removal of PPSCC. To address this void, investigators from Italy developed a nomogram predicting PPSCC-specific mortality (11). This model represents the first standardized and individualized prognostic tool for patients treated with partial or total penectomy.…”

Section: Discussionmentioning

confidence: 99%

“…To circumvent these limitations, we attempted to develop a simpler prognostic rule that could be used in men from the United States. Our goal was to rely on routinely available pathologic variables and to achieve an equal accuracy, relative to the previously reported Italian nomogram (11).…”

Section: Discussionmentioning

confidence: 99%

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A Simple and Accurate Model for Prediction of Cancer-Specific Mortality in Patients Treated with Surgery for Primary Penile Squamous Cell Carcinoma

Zini

Cloutier

Isbarn

et al. 2009

Clinical Cancer Research

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Purpose: Cancer-specific mortality (CSM) of patients with primary penile squamous cell carcinoma (PPSCC) may be quite variable. Recently, a nomogram was developed to provide standardized andindividualized mortality predictions. Unfortunately, it relies on a large number (n = 8) of specific variables that are unavailable in routine clinical practice.We attempted to develop a simpler prediction rule with at least equal accuracy in predicting CSM after surgical removal of PPSCC. Experimental Design: The predictive rule was developed on a cohort of 856 patients identified in the 1988 to 2004 Surveillance, Epidemiology and End Results (SEER) database.The predictors consisted of age, race, SEER stage (localized versus regional versus metastatic), tumor grade, type of surgery (excisional biopsy, partial penectomy, and radical penectomy), and of lymph node status (pN 0 versus pN 1-3 versus pN x ). A look-up table based on Cox regression model-derived coefficients was used for prediction of 5-year CSM.The predictive rule accuracy was tested using the Harrell's modification of the area under the receiver operating characteristics curve. Results: SEER stage and histologic grade achieved independent predictor status and qualified for inclusion in the model. The model achieved 73.8% accuracy for prediction of CSM at 5 years after surgery. Both predictors achieved independent predictor status in competing risk regression models addressing CSM, where other cause mortality was controlled for. Conclusion: Despite equivalent accuracy, ourpredictive rulepredicting 5-year CSMinpatients with PPSCC is substantially less complex (2 versus 8 variables) than the previously published model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Simple and Accurate Model for Prediction of Cancer-Specific Mortality in Patients Treated with Surgery for Primary Penile Squamous Cell Carcinoma

Zini

Cloutier

Isbarn

et al. 2009

Clinical Cancer Research

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“…8,18 These features, along with the prognostic role of prior or concomitant bladder cancers, strongly reconfirm the panurothelial nature of the disease. It has been demonstrated that the presence of lymphovascular invasion is an important prognostic factor in other urologic malignancies, including prostate cancer, 21 squamous cell carcinoma of the penis, 22 and bladder TCC. 23 Hong et al, reporting on a series of 86 patients who underwent nephroureterectomy for UUT-TCC, demonstrated that lymphovascular invasion was an independent prognostic factor for recurrence-free (but not cancer-specific) survival probabilities.…”

Section: Discussionmentioning

confidence: 99%

Independent predictors of cancer‐specific survival in transitional cell carcinoma of the upper urinary tract

Novara

Marco

Gottardo

et al. 2007

Cancer

Self Cite

175

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Sulfonation degree determination of sulfonated polystyrene and the corresponding ionomers are performed by adiabatic bomb calorimeter. The theoretical calculations from the band energies for the combustion enthalpy values (calorific values) and the experimental values are compared, and a linear relation between the values is found. Sulfonation and neutralization processes are examined by elemental sulfur analysis and atomic absorption spectroscopy (AAS). It was obvious that increasing sulfonation degree yields a decrease in the combustion enthalpy values, as it is expected from the theoretical calculations. In addition, metal ion incorporation to the structure deviates the experimental combustion enthalpy values especially for the ionomers which have higher sulfonation degrees. This is due to the formation of a higher degree aggregation. © Wiley Periodicals, Inc. J Appl Polym Sci 100: 4684–4688, 2006

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“…4,7,8 Recent series have demonstrated rates of clinical node positivity at presentation between 22% and 61%. 5,9,10 Lymphadenopathy in patients with clinically palpable nodal disease should be reconciled between reactive adenopathy and true metastatic disease, as infection of this cutaneous neoplasm can also enlarge nodes in the groin. False-positive rates for palpable adenopathy can exceed 50%.…”

mentioning

confidence: 99%

What next? Managing lymph nodes in men with penile cancer

Leveridge

Morash

2013

CUAJ

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The management of patients with squamous cell carcinoma of the penis is often daunting given its rarity and subsequent lack of high-level evidence to support our decision-making. This culminates in the complex surgical issues involving the management of the regional lymph nodes, which is of critical importance to both quantity and quality of life for these patients. This review aims to highlight the decisive issues surrounding the management of the pelvic and inguinal lymph nodes in the setting of squamous cell carcinoma of the penis, and to spotlight recently published information that adds credence to accepted management strategies of both the clinically positive and negative groin after successful management of the primary lesion.

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Nomogram Predictive of Cancer Specific Survival in Patients Undergoing Partial or Total Amputation for Squamous Cell Carcinoma of the Penis

Cited by 104 publications

References 15 publications

A Simple and Accurate Model for Prediction of Cancer-Specific Mortality in Patients Treated with Surgery for Primary Penile Squamous Cell Carcinoma

A Simple and Accurate Model for Prediction of Cancer-Specific Mortality in Patients Treated with Surgery for Primary Penile Squamous Cell Carcinoma

Independent predictors of cancer‐specific survival in transitional cell carcinoma of the upper urinary tract

What next? Managing lymph nodes in men with penile cancer

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