Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Dai, De-Chang; Chen, Bin; Tang, Hailin; Wang, Bin; Zhao, Zhiping; Xie, Xiaoming; Wei-dong, Wang

doi:10.1371/journal.pone.0161902

Cited by 24 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The value of tumor markers varies depending on the molecular sub-group. To determine the cut-off value with the strongest prognostic ability, several different cut-off values have previously been applied for CEA (2-10 ng/ml) and CA15-3 (21.8-60 U/ml) (12,14,18,(38)(39)(40)(41). In the present study, CEA and CA15-3 were identified as prognostic predictors for young patients with breast cancer according to ROC curve analysis.…”

Section: Discussionmentioning

confidence: 92%

“…Among several tumor markers, CEA and CA15-3 are the two most widely used for breast cancer. Numerous studies have been performed to quantitatively evaluate the serum levels of these two tumor markers, which have identified a wide range of cut-off values for predicting the prognosis of poor survival in breast cancer (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). At present, the predictive abilities of CEA and CA15-3 remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Ebeling et al (22) investigated 1,046 patients with breast cancer and identified via multivariate analysis that CA15-3 was not a predictor for poor outcome; however, as reviewed by Duffy (23), increased CA15-3 may be associated with a poor outcome in patients with breast cancer. Despite CEA exhibiting a lower positive rate (positive CEA values ranged from 1.99-10 ng/ml, and positive CEA levels ranged from 7.1-36%) in breast cancer, there are fewer large-scale studies investigating its prognostic ability (12,(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

To the best of our knowledge, no previous study has investigated the association of carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) with the prognosis for young patients (≤40 years) with breast cancer. In the present study, preoperative CEA and CA15-3 serum levels were evaluated in the prediction of the prognosis for young patients with breast cancer. In total, 699 patients were recruited, for which the CEA and CA15-3 serum levels had been measured prior to surgery via a blood sample. The optimal cut-off high and low values were determined using receiver operating characteristic curve analysis and Youden's index. The value of CEA and CA15-3 in predicting overall survival (OS) and disease-free survival (DFS) were measured using univariate and multivariate Cox's regression analyses. The cut-off values were 3.38 ng/ml and 12.32 U/ml for CEA and CA15-3, respectively. It was identified that CEA, but not CA15-3, was a predictor for the prognosis of the young patients with breast cancer. Multivariate analysis confirmed that CEA, but not CA15-3, was an independent prognostic marker for all young patients with breast cancer. In total, 623 young patients exhibited decreased levels of CEA; in these patients, CA15-3 with a cut-off value of 12.48 U/ml was an independent prognostic factor for OS and DFS. Preoperative serum CEA may thus serve as an independent predictor of poor prognosis for young patients with breast cancer. However, for low-risk patients with decreased CEA levels, serum CA15-3 may supplement the prediction of overall prognosis.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…CEA is less widely investigated as a prognostic factor than CA15-3 because it has a less positive rate and is more controversial. Some studies have reported that CEA is not a predictor in primary and metastasis breast cancer [ 20 , 21 , 23 , 24 ], but others have reported that high concentrations of CEA were related to a poor prognosis in breast cancer [ 17 , 25 , 26 ]. These above contradictory results of CA15-3 and CEA in breast cancer regarding their prognostic value may be due to small sample sizes, variable study designs, or other biases in each single study.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and Prognostic Significance of Cancer Antigen 15-3 and Carcinoembryonic Antigen in Breast Cancer: A Meta-Analysis including 12,993 Patients

Dai

Chen

et al. 2018

Disease Markers

Self Cite

View full text Add to dashboard Cite

Purpose The prognostic role of serum cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) in breast cancer remains controversial. In this study, we conducted a meta-analysis to investigate the prognostic value of these two markers in breast cancer patients. Methods After electronic databases were searched, 36 studies (31 including information regarding CA15-3 and 23 including information regarding CEA) with 12,993 subjects were included. Based on the data directly or indirectly from the available studies, the hazard ratios (HRs) and odds ratios (ORs) and their 95% confidence intervals (CIs) were pooled according to higher or lower marker levels. Results Elevated CA15-3 or CEA was statistically significant with poorer DFS and OS in breast cancer (multivariate analysis of OS: HR = 2.03, 95% CI 1.76–2.33 for CA15-3; HR = 1.79, 95% CI 1.46–2.20 for CEA; multivariate analysis of DFS: HR = 1.56, 95% CI 1.06–1.55 for CA15-3; HR = 1.77, 95% CI 1.53–2.04 for CEA). Subgroup analysis showed that CA15-3 or CEA had significant predictive values in primary or metastasis types and different cut-offs and included sample sizes and even the study publication year. Furthermore, elevated CA15-3 was associated with advanced histological grade and younger age, while elevated CEA was related to the non-triple-negative tumor type and older age. These two elevated markers were all associated with a higher tumor burden. Conclusions This meta-analysis showed that elevated serum CA15-3 or CEA was associated with poor DFS and OS in patients with breast cancer, and they should be tested anytime if possible.

show abstract

“…who carried out a research on serum CA15-3 in different stages of breast cancer. On the contrary, Dai et al, [16] found that CA15-3 was elevated in 7.7%, 20.6%, 35.7% and 63.5% of patients with stage I, II, III, IV breast cancer respectively, (Cut off: 21.8U/ml). This can be explained by the fact that increased concentrations of CA 15-3 may be elevated in patients with benign ovarian cysts, benign breast disease, and benign liver disease.…”

Section: Sensiti Vity and Specificity Of Ca15-3 Cea And Mammaglobin mentioning

confidence: 90%

Assesment of Human Mammaglobin (hMAG) as a New Marker for Early Diagnosis of Breast Cancer

Seddik¹,

El-Gammal

2018

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Breast cancer may originate either from the ducts, known as ductal carcinomas or from the lobules, known as lobular carcinomas. There are many different types of breast cancer, with different stages (spread), aggressiveness, and genetic makeup. Breast cancer is the most frequent cancer in women affecting approximately 6% of the females. It constitutes almost 20% of all malignancies in women. In Egypt, breast cancer affects 37.7% of all women and accounts for 29.1% of their cancer-related mortality with a total of 6546 deaths.

show abstract

Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Cited by 24 publications

References 35 publications

Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer

Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer

Clinicopathological and Prognostic Significance of Cancer Antigen 15-3 and Carcinoembryonic Antigen in Breast Cancer: A Meta-Analysis including 12,993 Patients

Assesment of Human Mammaglobin (hMAG) as a New Marker for Early Diagnosis of Breast Cancer

Contact Info

Product

Resources

About