Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst

Ferri, Lorenzo; Filardi, Marco; Moresco, Monica; Pizza, Fabio; Vandi, Stefano; Antelmi, Elena; Toni, Francesco; Zucchelli, Mino; Pierangeli, Giulia; Plazzi, Giuseppe

doi:10.5664/jcsm.6816

Cited by 17 publications

(14 citation statements)

References 12 publications

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“…Pineal cysts potentially influence melatonin production; however, this has only been observed in a case report and in another small patient sample. 4,5 In support of this, we found men with pineal cysts and/or calcifications had higher | 493 mean melatonin than men without pineal calcification or cyst. We also observed men with calcification and cyst had lower risk for advanced prostate cancer, compared to men with no calcifications or cysts.…”

Section: Discussionsupporting

confidence: 69%

“…Pineal calcification has been reported both to have no effect on melatonin levels and to have been associated with lower melatonin levels, 2,3 and the effect of pineal cysts on melatonin levels has only been reported for small case reports (N <5), which differ in their findings. 4,5 Our group previously found a positive association between pineal parenchyma volume and 6-sulfatoxymelatonin levels in a sample of 122 men from the Age, Gene/ Environment Susceptibility-Reykjavik (AGES-Reykjavik) Study, an Icelandic cohort. 6 Other studies with small sample sizes have also reported positive correlations between pineal gland volume and melatonin levels, as measured in urine, plasma, and saliva.…”

Section: Introductionmentioning

confidence: 99%

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Exploratory assessment of pineal gland volume, composition, and urinary 6‐sulfatoxymelatonin levels on prostate cancer risk

et al. 2021

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Introduction: Melatonin levels are partially driven by the parenchyma volume of the pineal gland. Low urinary levels of 6-sulfatoxymelatonin have been associated with increased risk of advanced prostate cancer, but the relationship between pineal gland volume and composition and prostate cancer risk has not been examined. Materials and Methods:We utilized data from 864 men from the AGES-Reykjavik Study with complete pineal gland volumes and urinary 6-sulfatoxymelatonin measurements. Pineal parenchyma, calcification, and cyst volumes were calculated from brain magnetic resonance imaging. Levels of 6-sulfatoxymelatonin were assayed from prediagnostic urine samples. We calculated Pearson correlation coefficients between parenchyma volume and urinary 6-sulfatoxymelatonin levels.We used Cox proportional hazards regression to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) comparing prostate cancerThe study is approved by the AGES-Reykjavik steering committee. risk across parenchyma volume tertiles and across categories factoring in parenchyma volume, gland composition, and urinary 6-sulfatoxymelatonin level.Results: Parenchyma volume was moderately correlated with urinary 6-sulfatoxymelatonin level (r = .24; p < .01). There was no statistically significant association between parenchyma volume tertile and prostate cancer risk. Men with high parenchyma volume, pineal cysts and calcifications, and low urinary 6-sulfatoxymelatonin levels had almost twice the risk of total prostate cancer as men with low parenchyma volume, no pineal calcifications or cysts, and low urinary 6-sulfatoxymelatonin levels (HR: 1.98; 95% CI: 1.02, 3.84; p: .04).Conclusions: Although parenchyma volume is not associated with prostate cancer risk, pineal gland composition and other circadian dynamics may influence risk for prostate cancer. Additional studies are needed to examine the interplay of pineal gland volume, composition, and melatonin levels on prostate cancer risk.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Exploratory assessment of pineal gland volume, composition, and urinary 6‐sulfatoxymelatonin levels on prostate cancer risk

et al. 2021

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“…They are linked to physiological dysfunctions of internal clock, circadian cycle or hormonal systems involved, like dopaminergic system and melatonin [1][2][3][4][5] . SD are often associated with age related comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances are Consequences or Mediators between Socioeconomic Status and Health: A Scoping Review

Sosso¹,

Papadopoulos²,

Surani³

et al. 2019

Preprint

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The variations in socioeconomic status (SES) between different social classes of a population correspond to differences in accessibility to all resources available and able to improve global health. SES can influence global health trajectory for an individual or a community, depending if SES is low or high. Sleep is sensitive to environmental stimuli, as well as living conditions. Plenty of studies linked sleep complaints with mood disorders, allostatic load or circadian disruption; but very few or none investigated deeply what happened earlier to sleep depending of SES. While SES is now known as one of the main determinants for a good health and a good aging, its influence on sleep disorders (SD) is not well understood. SES is a concept, not directly observable but estimated using indicators like income, education, occupational status and area of living. Even if recent evidence suggested that few of SES indicators like occupational status are linked with sleep disturbances, the relation between SES and health in general with sleep as an outcome or a mediator is not well documented. This scoping review synthetized studies which investigated physiological and psychological mechanisms resulting from a low SES and linked them with sleep disturbances as consequences or as mediators. This review also explore a possible role played by sleep in the relation between socioeconomic status and health inequalities.

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“…Sleep disorders (SD) are among the most studied neurological outcomes since the last 20 years. They have many psychosocial aetiologies like lifestyle, night shift, sporadic daily stressors or environmental stress; and obviously they are linked to physiological dysfunctions of internal clock, circadian cycle or hormonal systems involved, like dopaminergic system and melatonin (Baron and Reid, 2014, Borbely, 1982, Diez-Garcia and Garzon, 2017, Ferri et al, 2017, Leger and Ogrizek, 2012. SD are often associated with comorbidities depending of age.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories

Sosso¹,

Papadopoulos²

2018

Preprint

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The variations in socioeconomic status (SES) between different social classes of a population correspond to differences in accessibility to all resources available and able to improve global health. While SES is now known as one of the main determinants for a good health and a good aging, its influence on sleep disorders (SD) is not well understood. SES is a concept, not directly observable but estimated using indicators like income, education, occupational status and area of living. This theoretical review explores some theories linking environment of people with occurrence of SD, with different patterns associated to SES. A model of interaction is proposed to summarize and conceptualizes these interactions and to promote more research on the topic. ) 90 . The main confounding factor in this relation is age, which increase for every human and create conditions for chronic diseases, regardless of SES 89,91 . Lo and Lee explored SD among seniors by investigating the prevalence of poor sleep quality, the relationship between sleep quality and health-related quality of life, and associated factors of good sleepers in different age group. They conclude on a negative association between poor quality and short-term sleep with a healthy quality of life and stated that such association worsens with aging 92 . Similar conclusions for Green et al. who studied patterns of insomnia symptoms as people age and examines how they vary according to gender and profession, using data of three cohorts followed for 20 years. They found that chronic symptoms of insomnia -expressed by difficulties in maintaining and initiating sleep-are influenced by social factors (Green et al., 2012). Sleep disturbances appear, regardless of context, associated to SES. Sleep disorders is the result of allostatic load and in the same time the predicting sign that an individual reach his social resilience limit, as depicted in the following model ( Figure 1). Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 10 December 2018 Preprints (www.preprints.org) | NOT PEER-REVIEWED |

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Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst

Cited by 17 publications

References 12 publications

Exploratory assessment of pineal gland volume, composition, and urinary 6‐sulfatoxymelatonin levels on prostate cancer risk

Exploratory assessment of pineal gland volume, composition, and urinary 6‐sulfatoxymelatonin levels on prostate cancer risk

Sleep Disturbances are Consequences or Mediators between Socioeconomic Status and Health: A Scoping Review

Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories

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