Non-adenine based purines accelerate wound healing

Jiang, Shucui; Zavitz, Caleb C. J.; Wang, Jian; Saraf, Amit; Zielinski, Robert; Ramsbottom, James D.; Ballerini, Patrizia; D’Alimonte, Iolanda; Romano, Silvia; Fischione, Gemma; Traversa, U.; Werstiuk, Eva S.; Rathbone, Michel P.

doi:10.1007/s11302-006-9022-2

Cited by 8 publications

(3 citation statements)

References 58 publications

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“…Importantly, our data show significantly elevated levels of UA and a corresponding decrease in purine precursors in WF from clinically worse ulcers (Figures 2 and 3). Interestingly, previous reports indicate that topical application of purine precursors accelerates wound healing in various animal and cell culture models (33–35). In particular, adenosine has been shown to play an important role in stimulating wound healing (36,37).…”

Section: Discussionmentioning

confidence: 99%

Elevated uric acid correlates with wound severity

Fernandez

Upton

Edwards

et al. 2011

International Wound Journal

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Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. We have also shown a corresponding depletion in UA precursors, including adenosine, with increased wound severity. Further, we have shown that xanthine oxidase, the only enzyme in humans that catalyses the production of UA in conjunction with a burst of free radicals, is active in chronic WF. Taken together, this provides compelling evidence that xanthine oxidase may play a critical role in the formation of chronic wounds by prolonging the inflammatory process.

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Section: Discussionmentioning

confidence: 99%

Elevated uric acid correlates with wound severity

Fernandez

Upton

Edwards

et al. 2011

International Wound Journal

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“…Studies of coenzyme Q10, which is a biosynthesized quinone known to possess anti‐inflammatory effects have shown it to aid the skin barrier repair/wound healing process . Furthermore, the purine metabolism pathway showed increased signal intensities of two metabolites and research has shown that non‐adenine based purines promote cell proliferation and release growth factors, thus accelerating wound closure . Other metabolites with raised signal intensities in the highlighted metabolic pathways in Table have shown to improve the skin barrier repair/wound healing process by stimulating keratinocytes, inducing antioxidative responses or stimulating the biosynthesis of collagen .…”

Section: Discussionmentioning

confidence: 99%

Examination of the skin barrier repair/wound healing process using a living skin equivalent model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging

Lewis

Barrett²,

Freeman-Parry

et al. 2018

Intern J of Cosmetic Sci

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This novel method of coupling an in vitro LSE with MSI allowed in-depth molecular analysis of the skin barrier repair/wound healing process. The technique allowed the identification of lipids directly involved in the skin barrier repair/wound healing process, indicating these biomarkers may be potentially be used within the clinic. These biomarkers will help to determine, which stage of the skin barrier repair/wound healing process the wound is in to provide the best treatment.

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“…Non-adeninebased purines (NABPs) are known to promote cell proliferation and release of growth factors (NGF). Jiang et al studied the effect of NABPs on wound healing (43). Cotreatment of wounds with guanosine plus anti-NGF reversed the guanosine-promoted acceleration of wound healing, indicating that the effect of guanosine is mediated in part by NGF.…”

Section: Wound Healing and Tissue Remodelingmentioning

confidence: 99%

The functions of nerve growth factor and nerve growth factor receptor in wound healing

et al. 2012

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Nerve growth factor (NGF) and nerve growth factor receptors (NGFRs) play important roles in tissue remodeling during the would healing process of the skin, oral and paranasal mucosa, and cornea. The interactions between NGF and NGFRs are influenced by or interact with a number of molecules in the tissue remodeling process, in which key niche components are varieties of growth factors and their receptors, including NGF and NGFR. In addition to those interactions mentioned above, cell-cell contacts as well as cell-matrix interactions have also been considered to promote wound healing events. The present review focuses on the pathophysiological roles of NGF and NGFR in saliva and salivary glands, and in tear and lacrimal glands under inflammatory and tissue remodeling conditions, as well as their expression profiles in various kinds of cells including mast cells, macrophages, lymphocytes, and those involved in angiogenesis. Finally, we describe how the expression modes of NGF and NGFR regulate the peripheral nerve fiber growth and stimulate wound healing or tissue remodeling in the organs or tissues mentioned above as well as in pressure wounds and diabetic skin lesions. Based on these lines of evidence, we emphasize that NGF and NGFR could represent new and powerful regimens for treatment of tissue injuries.

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Non-adenine based purines accelerate wound healing

Cited by 8 publications

References 58 publications

Elevated uric acid correlates with wound severity

Elevated uric acid correlates with wound severity

Examination of the skin barrier repair/wound healing process using a living skin equivalent model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging

The functions of nerve growth factor and nerve growth factor receptor in wound healing

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