2020
DOI: 10.1007/5584_2020_532
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Non-alcoholic Fatty Liver Disease and Diabetes Mellitus

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Cited by 24 publications
(20 citation statements)
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“…E p i d e m i o l o g i c a l s t u d i e s h a v e s h o w n a s t r o n g bidirectional relationship between MAFLD and T2DM. T2DM is strongly correlated with steatohepatitis progression to steatohepatitis, liver fibrosis, and/or HCC, MAFLD is associated with an increased risk of macrovascular and microvascular complications of T2DM and chronic kidney diseases (7)(8)(9). In patients with T2DM, the prevalence rates of MAFLD and steatohepatitis ranged 70-95% and 17.6-22%, respectively (5,10).…”
Section: Introductionmentioning
confidence: 99%
“…E p i d e m i o l o g i c a l s t u d i e s h a v e s h o w n a s t r o n g bidirectional relationship between MAFLD and T2DM. T2DM is strongly correlated with steatohepatitis progression to steatohepatitis, liver fibrosis, and/or HCC, MAFLD is associated with an increased risk of macrovascular and microvascular complications of T2DM and chronic kidney diseases (7)(8)(9). In patients with T2DM, the prevalence rates of MAFLD and steatohepatitis ranged 70-95% and 17.6-22%, respectively (5,10).…”
Section: Introductionmentioning
confidence: 99%
“…As noted in Section 1, several off-label treatments have been explored as potentially suitable therapies for patients with NAFLD and NASH. For example, the efficacy of insulin-sensitizing medications, such as thiazolidinediones and metformin, has been assessed in small randomized controlled trials ( 66 ). Of these, pioglitazone is the most studied drug in patients with NAFLD and remains the only recommended medication for NAFLD or NASH (although it should be noted that this is off-label usage) ( 67 ).…”
Section: Disease Managementmentioning
confidence: 99%
“…with obesity and considered part of the metabolic syndrome (116). T2DM is accompanied by chronic inflammation and oxidative stress (117) and patients often develop non-alcoholic fatty liver disease (118). Insulin is the cause of hyperglycemia in T1 DM.…”
Section: Diabetesmentioning
confidence: 99%