2022
DOI: 10.26442/00403660.2022.10.201921
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Non-alcoholic fatty liver disease and type 2 diabetes mellitus: general approaches to the choice of therapy

Abstract: Currently, there is a growing interest in one of the most common diseases in hepatology non-alcoholic fatty liver disease (NAFLD). There is evidence that approximately 75% of cases of NAFLD occur against the background of obesity, dyslipidemia or type 2 diabetes mellitus (T2DM). At the present stage, a persistent pathophysiological interaction between NAFLD and T2DM has been demonstrated. Insulin resistance is one of the main pathogenetic causes of the development of T2DM and NAFLD. At the same time, it is ne… Show more

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Cited by 3 publications
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“…In a prospective study of 100 patients with type 2 diabetes, the incidence of hepatic steatosis was 49%, suggesting this strong independent risk factor for MASLD [34]. Diabetes mellitus is the most evident biological connection to the development of MASLD, with as many as 75% of individuals with type 2 diabetes also having MASLD [35]. Diabetes is not only a common comorbidity of MASLD but also one of the determinants of the progression of MASLD toward MASH, developing accelerated liver fibrosis and HCC [36].…”
Section: Type 2 Diabetes Mellitusmentioning
confidence: 99%
“…In a prospective study of 100 patients with type 2 diabetes, the incidence of hepatic steatosis was 49%, suggesting this strong independent risk factor for MASLD [34]. Diabetes mellitus is the most evident biological connection to the development of MASLD, with as many as 75% of individuals with type 2 diabetes also having MASLD [35]. Diabetes is not only a common comorbidity of MASLD but also one of the determinants of the progression of MASLD toward MASH, developing accelerated liver fibrosis and HCC [36].…”
Section: Type 2 Diabetes Mellitusmentioning
confidence: 99%