Non-alcoholic fatty liver disease: identical etiologic factors in patients with type 1 and type 2 diabetes

Vries, Marieke de; El-Morabit, Fatima; Erpecum, Karel J. van; Westerink, Jan; Bac, Simon; Kaasjager, H. A. H.; Valk, Harold W. de

doi:10.1016/j.ejim.2022.03.025

Cited by 23 publications

(14 citation statements)

References 31 publications

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“…Similarly, a recent cross‐sectional study exploring diabetic patients by transient elastography of the liver reported a lower prevalence (2.0%) of advanced fibrosis (i.e., ≥F3) in patients with T1DM, as compared to those with T2DM (22%). In both types of diabetes, the extent of insulin sensitivity is negatively linked with the presence of NAFLD, independently of age, sex and diabetes duration 236 . However, a recent survey on 115 patients with T1DM revealed an average NAFLD prevalence of 47%, in the presence of overweight or obesity, poor glycemic control and accumulation of two metabolic syndrome components, besides hyperglycemia 224 .…”

Section: Diabetes and The Gastrointestinal Tractmentioning

confidence: 99%

Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract

Portincasa

Bonfrate

Wang

et al. 2022

Eur J Clin Investigation

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Type 2 and type 1 diabetes are common endocrine disorders with a progressively increasing incidence worldwide. These chronic, systemic diseases have multiorgan implications, and the whole gastrointestinal (GI) tract represents a frequent target in terms of symptom appearance and interdependent pathophysiological mechanisms. Metabolic alterations linked with diabetic complications, neuropathy and disrupted hormone homeostasis can lead to upper and/or lower GI symptoms in up to 75% of diabetic patients, with multifactorial involvement of the oesophagus, stomach, upper and lower intestine, and of the gallbladder. On the other hand, altered gastrointestinal motility and/or secretions are able to affect glucose and lipid homeostasis in the short and long term. Finally, diabetes has been linked with increased cancer risk at different levels of the GI tract. The presence of GI symptoms and a comprehensive assessment of GI function should be carefully considered in the management of diabetic patients to avoid further complications and to ameliorate the quality of life. Additionally, the presence of gastrointestinal dysfunction should be adequately managed to improve metabolic homeostasis, the efficacy of antidiabetic treatments and secondary prevention strategies.

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Section: Diabetes and The Gastrointestinal Tractmentioning

confidence: 99%

Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract

Portincasa

Bonfrate

Wang

et al. 2022

Eur J Clin Investigation

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show abstract

“…Another study looked into etiologic factors of NAFLD development in patients with T1D and T2D using transient elastography to diagnose NAFLD and to assess the presence or absence of advanced liver fibrosis. This study reported that NAFLD prevalence in T1D patients (N=150) was 20% (N=30) and 76% (N=76) in T2D patients (N=100) ( 27 ). Advanced liver fibrosis was found in 2% (N=3) of T1D patients and in 22% (N= 22) of T2D patients.…”

Section: Methodsmentioning

confidence: 88%

“…Advanced liver fibrosis was found in 2% (N=3) of T1D patients and in 22% (N= 22) of T2D patients. Hepatic steatosis was estimated by controlled attenuation parameter and hepatic fibrosis by liver stiffness measurement using transient elastography ( 27 ). Interestingly, larger waist circumference, higher BMI and presence of metabolic syndrome were all positively associated with the presence of NAFLD in both groups, whereas insulin sensitivity, calculated with estimated glucose disposal rate and SEARCH estimated insulin sensitivity, were negatively associated with the presence of NAFLD ( 27 ).…”

Section: Methodsmentioning

confidence: 99%

Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and pathophysiology

Memaj

Jornayvaz

2022

Front. Endocrinol.

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Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the general population with a global prevalence of 25%. It is often associated with metabolic syndrome and type 2 diabetes, as insulin resistance and hyperinsulinemia are known to be favoring factors. Recent studies have described growing incidence of NAFLD in type 1 diabetes (T1D) as well. Although increasing prevalence of metabolic syndrome in these patients seems to explain part of this increase in NAFLD, other underlying mechanisms may participate in the emergence of NAFLD. Notably, some genetic factors are more associated with fatty liver disease, but their prevalence in T1D has not been evaluated. Moreover, oxidative stress, poor glucose control and long-lasting hyperglycemia, as well as exogenous insulin administration play an important role in intrahepatic fat homeostasis. The main differential diagnosis of NAFLD in T1D is glycogenic hepatopathy, which needs to be considered mostly in T1D patients with poor glycemic control. This article aims to review the prevalence and pathophysiology of NAFLD in T1D and open perspectives for clinicians taking care of T1D patients with potential hepatopathy.

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“…Nowadays, few data are available regarding the prevalence of NAFLD in people with T1DM. Some studies reported that ultrasound-diagnosed NAFLD was present in nearly 20–30% of adult patients with T1DM [ 50 , 51 ]. Clinically, patients will not have any symptoms besides fatigue, but in advanced stages due to the development of liver cirrhosis, they can develop ascites, esophageal varices, and jaundice.…”

Section: Non-alcoholic Fatty Liver Disease and Diabetesmentioning

confidence: 99%

Gastrointestinal and Liver Complications in Patients with Diabetes Mellitus—A Review of the Literature

Mare

Sporea

2022

JCM

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The number of diabetes mellitus patients has increased over the last few years in developing countries, along with obesity and sedentary lifestyle. Besides macroangiopathy and microangiopathy, damage to the nerve fibers of the peripheral nervous system is the most common chronic complication of diabetes. Digestive complications in diabetic patients represent a consequence of diabetic autonomic neuropathy involving the gastrointestinal tract, but unfortunately not always evaluated by diabetologists. Aside from the complications encountered in the digestive tract, patients with diabetes mellitus are prone to developing liver diseases. This review will describe the prevalence of these complications, the modality of diagnosis, and therapeutical solutions in order to reduce the risk of progression of these complications in diabetic subjects.

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Non-alcoholic fatty liver disease: identical etiologic factors in patients with type 1 and type 2 diabetes

Cited by 23 publications

References 31 publications

Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract

Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract

Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and pathophysiology

Gastrointestinal and Liver Complications in Patients with Diabetes Mellitus—A Review of the Literature

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