Non-alcoholic fatty liver disease prevalence and associated risk factors – A study from rural sector of Maharashtra

Lavekar, Anurag; Aniket, Saoji; Jadhav, Shalik; Amarja, Lavekar; Dhananjay, Raje; Sachin, Jibhkate

doi:10.7869/tg.241

Cited by 20 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Lavekar A et al (2015) studied 302 individuals with prevalence of NAFLD of 28.1%, which was relatively low compared to our study as we have enrolled only type -2 DM subjects which is one of the proved risk factor for NAFLD. 13 Prabhakar A et al (2017) quoted prevalence of NAFLD was 41.2% in the study group (n=114), which is similar to present study. Prevalence of NAFLD was significantly associated with HbA1c, duration of diabetes and obesity, these findings are comparable with our study.…”

Section: Discussionsupporting

confidence: 91%

Study of the Frequency of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (DM) in a Tertiary Care Centre

Malakar¹,

Patil²

2018

IJCMSR

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Study of the Frequency of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (DM) in a Tertiary Care Centre

Malakar¹,

Patil²

2018

IJCMSR

View full text Add to dashboard Cite

show abstract

“…A study in the Indian state of Haryana, showed prevalence of NAFLD to be 30% in patients from rural villages reporting for US 10. Similarly, another study also conducted in rural India last year showed that the prevalence of NAFLD in patients undergoing routine US was 28.1% 11. Also of note, NAFLD prevalence, even in non-diabetic patients, was found to be high, with an estimate of 24.7% in one study for an urban population 12.…”

Section: Prevalence Of Nafld/nash In South Asiamentioning

confidence: 97%

Non-alcoholic Fatty Liver Disease in South Asians: A Review of the Literature

Singh¹,

Kuftinec²,

Sarkar³

2017

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are national and global epidemics. The disease is characterized by a spectrum of liver steatosis (fat deposition), inflammation (in NASH) and fibrosis. NAFLD and specifically NASH can lead to cirrhosis, which carry risks of progression to portal hypertension and hepatocellular carcinoma (HCC). NASH is also associated with higher mortality from cardiovascular causes. Most of the data for NAFLD has been obtained from the perspective of developed nations, although the disease is increasing and threatening to reach epidemic proportions across the world. Emerging data is notable for high prevalence of NAFLD in South Asian populations, presumably resulting from a combination of underlying genetic polymorphisms and changes in socio-economic status. It is also notable that an 'Asian Paradox' has been defined for NAFLD based upon the observation of lower than predefined body mass index (BMI), otherwise termed as "lean NAFLD", among this population. Yet, data remains limited in regards to the characteristics of NAFLD/NASH in this population. In this article, we present a review of the literature and discuss the prevalence, associated risk factors and burden of HCC in South Asians with NAFLD. Citation of this article: Singh S, Kuftinec GN, Sarkar S. Nonalcoholic fatty liver disease in South Asians: a review of the literature.

show abstract

“…NAFLD comprises a histopathological disease spectrum from bland steatosis to non-alcoholic steatohepatitis (NASH) with significant inflammation and fibrosis, progressing to cirrhosis in approximately 20% of patients with NASH [6]. Increased body mass index (BMI), metabolic syndrome, increased fasting blood glucose, and serum triglycerides are potentially strong indicators of NAFLD [7]. Due to the indolent asymptomatic nature of NAFLD, identifying individuals with advanced disease in whom specific interventions may be required remains a clinical challenge in primary care [1].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Investigation of Fatty Liver Disease and Abnormal Liver Function in the Republic of Kazakhstan

Nersesov¹,

Raissova²,

Kaibullayeva³

et al. 2019

OJEpi

View full text Add to dashboard Cite

Aim: Little is known about the epidemiology of fatty liver disease (FLD) among high-risk primary care subjects in Kazakhstan. We investigated the prevalence of FLD (alcoholic liver disease [ALD] and non-alcoholic fatty liver disease [NAFLD]) and abnormal liver function tests (LFTs) in high risk adults in Kazakhstan during their routine visit to the general practitioner. Methods: This multicenter, cross-sectional epidemiological study was carried out at 75 clinical sites in the Republic of Kazakhstan. The full analysis set population consisted of 5109 subjects. Results: Among type 2 diabetes mellitus (T2DM) subjects, established metabolic syndrome (MetS) and/or obese subjects, the prevalence of FLD was 30.8%. LFT abnormalities were found in 53.2% subjects with FLD and 40.0% without FLD. FLD subjects had significantly higher levels of alanine transaminase (ALT; p < 0.001), aspartate transaminase (AST; p < 0.001), serum total bilirubin (STB; p < 0.001), and gamma-glutamyl transpeptidase (GGT; p = 0.021) compared to those without FLD. LFTs increases were significantly higher in subjects with FLD compared to those without FLD and were also significantly higher in ALD subjects compared to those with NAFLD. Conclusion: This study provides insights into the prevalence of FLD and abnormal LFTs in subjects with T2DM and/or established MetS and/or who are obese in primary care settings in Kazakhstan. These findings can help healthcare providers in Kazakhstan and elsewhere to better recognize and manage patients at risk of liver disease, which will improve clinical outcomes.

show abstract

Non-alcoholic fatty liver disease prevalence and associated risk factors – A study from rural sector of Maharashtra

Abstract: Prevalence of NAFLD was found be 28.1%. Study confirms that the increased BMI, metabolic syndrome, increased fasting blood glucose and serum triglycerides are potentially strong indicators of NAFLD.

Cited by 20 publications

References 20 publications

Study of the Frequency of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (DM) in a Tertiary Care Centre

Study of the Frequency of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (DM) in a Tertiary Care Centre

Non-alcoholic Fatty Liver Disease in South Asians: A Review of the Literature

Epidemiological Investigation of Fatty Liver Disease and Abnormal Liver Function in the Republic of Kazakhstan

Contact Info

Product

Resources

About