Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis

Verlinden, Wim; Mieghem, Eugénie Van; Depauw, Laura; Vanwolleghem, Thomas; Vonghia, Luisa; Weyler, Jonas; Driessen, Ann; Callens, Dirk; Roosens, Laurence; Dirinck, Eveline; Verrijken, An; Gaal, Luc Van; Francque, Sven

doi:10.3390/biomedicines8120546

Cited by 2 publications

(2 citation statements)

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“…Here, labelled C13 urea is administered to patients, and then their exhaled breath is collected, where the isotope-labelled carbon dioxide is measured. Other C13 breath tests, such as the C13 aminopyrine breath test, have also been used to examine liver diseases [ 19 , 20 ]; however, C13 implementations are outside the scope of the present review since they are not based on VOC analysis. The current review focuses on endogenously formed compounds that have been connected with liver impairment, among which are nitrogen derivates [ 4 ], ketones [ 21 ], alkanes [ 21 ], sulphur derivates [ 1 ], and alcohols [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Liver Impairment—The Potential Application of Volatile Organic Compounds in Hepatology

et al. 2021

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Liver diseases are currently diagnosed through liver biopsy. Its invasiveness, costs, and relatively low diagnostic accuracy require new techniques to be sought. Analysis of volatile organic compounds (VOCs) in human bio-matrices has received a lot of attention. It is known that a musty odour characterises liver impairment, resulting in the elucidation of volatile chemicals in the breath and other body fluids such as urine and stool, which may serve as biomarkers of a disease. Aims: This study aims to review all the studies found in the literature regarding VOCs in liver diseases, and to summarise all the identified compounds that could be used as diagnostic or prognostic biomarkers. The literature search was conducted on ScienceDirect and PubMed, and each eligible publication was qualitatively assessed by two independent evaluators using the SANRA critical appraisal tool. Results: In the search, 58 publications were found, and 28 were kept for inclusion: 23 were about VOCs in the breath, one in the bile, three in urine, and one in faeces. Each publication was graded from zero to ten. A graphical summary of the metabolic pathways showcasing the known liver disease-related VOCs and suggestions on how VOC analysis on liver impairment could be applied in clinical practice are given.

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Section: Introductionmentioning

confidence: 99%

Liver Impairment—The Potential Application of Volatile Organic Compounds in Hepatology

et al. 2021

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“…The 13C-aminopyrine breath test (ABT) evaluates the microsomal liver function and could be a potential candidate to allow the discrimination between simple steatosis to NASH. Using this approach, in this Special Issue, Verlinden et al [ 5 ] aimed to evaluate a potential change in liver function in NASH patients and to assess the diagnostic power to detect NASH. They demonstrated that the microsomal liver function of patients with NASH is significantly decreased, even in the absence of fibrosis.…”

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confidence: 99%