Non-asbestos-related malignant mesothelioma. A review

Peterson, Jack T.; Greenberg, S. Donald; Buffler, Patricia A.

doi:10.1002/1097-0142(19840901)54:5<951::aid-cncr2820540536>3.0.co;2-a

Cited by 233 publications

(83 citation statements)

References 48 publications

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“…20 A variety of other causes of mesothelioma have been suggested based on case reports and animal studies, including therapeutic radiation. [21][22][23][24][25][26][27][28][29][30][31] There have been many case reports of mesothelioma after radiotherapy for various diseases, and the most numerous have been related to HL. [32][33][34][35][36][37][38][39] To our knowledge, the only epidemiology study to date that examined whether radiation increased mesothelioma rates in HL survivors followed 13,743 patients from 1973 to 1993 and reported no cases of mesothelioma.…”

mentioning

confidence: 99%

Therapeutic radiation for lymphoma

Teta

Lau

Sceurman

et al. 2007

Cancer

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BACKGROUNDIonizing radiation has been used since the 1950s to treat a variety of cancers. Cancer patients who are treated with radiotherapy have shown increased risks for a variety of second malignancies, including mesothelioma, in several recent reports. The only existing study of Hodgkin lymphoma (HL) and subsequent mesothelioma had a short observation period.METHODSThe authors used Surveillance, Epidemiology, and End Results data over a 30‐year period to identify patients with HL and non‐Hodgkin lymphoma (NHL) who also were diagnosed with mesothelioma. Standardized incidence ratios (SIR) and absolute excess risks were calculated by sex and treatment modality for both types of lymphoma.RESULTSTwenty‐six patients were identified who had mesothelioma as second primaries based on 21,881 diagnoses of HL and 101,001 diagnoses of NHL. There was a statistically significant increase in mesothelioma (4 diagnoses; SIR, 6.59; 95% confidence interval [95% CI], 1.79–16.87) among men with HL who received radiation, but no women survivors were identified who had a diagnosis of mesothelioma. For NHL survivors, there was a nonsignificant excess of mesothelioma among men (SIR, 1.91; 95% CI, 0.77–3.93) and women (SIR, 3.75; 95% CI, 0.77–10.95) who had received radiation treatment. There were no increases among patients who were unirradiated.CONCLUSIONSMesothelioma rates for patients who had received radiotherapy were increased for survivors of HL and NHL. No increases were observed among the unirradiated. These findings and the existing body of supporting studies confirmed that radiotherapy is a cause of mesothelioma. Cancer 2007. © 2007 American Cancer Society.

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confidence: 99%

Therapeutic radiation for lymphoma

Teta

Lau

Sceurman

et al. 2007

Cancer

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“…The association between mesothelioma and asbestos exposure was first reported by Wagner et al [9] in 1960. However, the relationship between peritoneal mesothelioma and asbestos is less obvious than that of pleural mesothelioma [10] . Liu et al [6] also have reported a non-asbestos-related primary mesothelioma of the greater omentum.…”

Section: Discussionmentioning

confidence: 99%

Malignant mesothelioma of the greater omentum mimicking omental infarction: A case report

Shin¹,

Lee²,

Ha³

et al. 2009

WJG

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Mesothelioma develops most commonly in the pleura, and less frequently in the peritoneum. Usually, it manifests as diffuse peritoneal thickening and multiple nodules, and rarely as a solitary mass. We report a rare case of primary malignant mesothelioma of the greater omentum, which mimicked omental infarct. A 54-year-old Korean man was admitted because of severe abdominal pain of sudden onset. A tender mass with indistinct margins was palpated in the upper abdomen. Abdominal ultrasound and computed tomography showed an illdefined mass in the greater omentum and little ascites in the peri-hepatic space, and neutrophil-dominant exudates were documented on paracentesis. Intravenous antibiotics and analgesics were given for omental infarction with superimposed infection, which resulted in symptomatic improvement. The imaging studies after a week revealed a growing mass and ascites. Laparoscopic surgery was performed and an 8 cm × 3.3 cm greater omental mass was found, with multiple small nodules on the peritoneum, diaphragm, and pelvic cavity wall. Histological examination showed proliferating malignant epithelioid cells that stained strongly for calretinin, which was compatible with malignant mesothelioma. We recommend that primary omental mesothelioma should be included in the differential diagnosis of patients with omental infarction, despite its rarity.

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“…También se ha detectado mediante el método de Western-blot anticuerpos anti-Tag en el suero de estos pacientes. 24 Al mismo tiempo, varios autores han seguido de forma retrospectiva a estos pacientes tratados con vacunas contaminadas, sin que hasta la fecha se haya registrado una mayor incidencia en la aparición de mesoteliomas y osteosarcomas. 29 Algunos autores mencionan la existencia de otros virus como BKV, 24 que actuarían como cofactores del SV40, mientras que otros relacionan el potencial cancerígeno del virus SV40 con su capacidad para interactuar, por medio de su oncoproteína (Tag), con proteínas supresoras del crecimiento como la P53, inactivándolas y favoreciendo así la aparición del MM.…”

Section: Discussionunclassified

“…24 Al mismo tiempo, varios autores han seguido de forma retrospectiva a estos pacientes tratados con vacunas contaminadas, sin que hasta la fecha se haya registrado una mayor incidencia en la aparición de mesoteliomas y osteosarcomas. 29 Algunos autores mencionan la existencia de otros virus como BKV, 24 que actuarían como cofactores del SV40, mientras que otros relacionan el potencial cancerígeno del virus SV40 con su capacidad para interactuar, por medio de su oncoproteína (Tag), con proteínas supresoras del crecimiento como la P53, inactivándolas y favoreciendo así la aparición del MM. 30 Estamos seguros de que los resultados obtenidos en este estudio representan un primer acercamiento para planear investigaciones prospectivas que tomen en cuenta análisis bioquímicos y moleculares más específicos, encaminados a establecer asociaciones con la patogénesis de la enfermedad.…”

Section: Discussionunclassified