Non-blood contacting biventricular support for severe heart failure

Anstadt, Mark P.; Schulte-Eistrup, S.; Motomura, Tadashi; Soltero, Ernesto R.; Tamaki, Toru; Mikati, Issam; Nonaka, Kenji; Joglar, Fernando; Nosé, Yukihiko

doi:10.1016/s0003-4975(01)03467-1

Cited by 17 publications

(4 citation statements)

References 11 publications

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“…11 An alternative technology-based approach to these shortcomings relies on epicardial systolic augmentation by direct cardiac compression (DCC), which avoids many of the drawbacks of the in-line blood-contacting biventricular assist devices. 12 DCC has been implemented in various forms during the past 50 years, including a pneumatic-driven rigid heartencircling ''cup'' 13 and a ''copulsation'' device 14 that assists the left and/or right ventricles. Despite improving the LVand RV cardiac output and myocardial energy efficiency, these devices have displayed static enhancement of ventricular function, without improvements to load-independent indexes and, thus, have relied on high-filling volumes to maintain a suitable mechanical therapeutic window.…”

mentioning

confidence: 99%

Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Mau

Menzie

Huang

et al. 2011

The Journal of Thoracic and Cardiovascular Surgery

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The HeartPatch DCC support of LV and RV function results from improvement of the systolic septal-lateral fractional change that is not influenced by septal infarction. The latter attenuated LV to RV device energy delivery during LV patch actuation but enhanced RV energy delivery during RV patch actuation. This DCC technique can provide effective support in high-risk RV failure situations arising from left ventricular assist device use.

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confidence: 99%

Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Mau

Menzie

Huang

et al. 2011

The Journal of Thoracic and Cardiovascular Surgery

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“…Several nonblood‐contact devices such as the CardioSupport system and the Heart Booster that assist the heart by direct compression of the external surface are currently under development (6,7). On the other hand, Anstadt's group first reported clinical experience with epicardial compression on the arrested heart using the Anstadt cup in 12 patients (9,10). Another significant case report is of successful circulatory support with an Anstadt cup lasting for 56 h with successful bridging to transplantation: the patient remains alive and well at 1‐year follow‐up (5).…”

Section: Discussionmentioning

confidence: 99%

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

et al. 2004

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“…To improve the device synchronization with heart function, a reliable physiological signal is required, from which we can easily infer the different contraction and relaxation stages of the target ventricle. Electric signals in the form of pacemaker stimulus or conventional electrocardiogram (ECG) have been used in extracardiac devices such as Anstadt Cup [18] and Heart booster (ABIOMED, Inc., Danvers, MA), respectively [19]. Recent studies on extracardiac soft robotic direct compression device have proposed the use of interventricular pressure signal for device synchronization [10,11].…”

Section: Introductionmentioning

confidence: 99%

Synchronization of a Soft Robotic Ventricular Assist Device to the Native Cardiac Rhythm Using an Epicardial Electrogram

Bautista‐Salinas

Hammer

Wamala

et al. 2020

Journal of Medical Devices

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Soft robotic devices have been proposed as an alternative solution for ventricular assistance. Unlike conventional ventricular assist devices (VADs) that pump blood through an artificial lumen, soft robotic VADs (SRVADs) use pneumatic artificial muscles (PAM) to assist native contraction and relaxation of the ventricle. Synchronization of SRVADs is critical to ensure maximized and physiologic cardiac output. We developed a proof-of-concept synchronization algorithm that uses an epicardial electrogram as an input signal and evaluated the approach on adult Yorkshire pigs (n = 2). An SRVAD previously developed by our group was implanted on the right ventricle (RV). We demonstrated an improvement in the synchronization of the SRVAD using an epicardial electrogram signal versus a RV pressure signal of 4 ± 0.5% in heart failure and 3.2 ± 0.5% during actuation for animal 1 and 7.4 ± 0.6% in heart failure and 8.2% ± 0.8% during actuation for animal 2. Results suggest that improved synchronization is translated in greater cardiac output. The pulmonary artery (PA) flow was restored to a 107% and 106% of the healthy baseline during RV electrogram actuation and RV pressure actuation, respectively, in animal 1, and to a 100% and 87% in animal 2. Therefore, the presented system using the RV electrogram signal as a control input has shown to be superior in comparison with the use of the RV pressure signal.

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Non-blood contacting biventricular support for severe heart failure

Cited by 17 publications

References 11 publications

Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

Synchronization of a Soft Robotic Ventricular Assist Device to the Native Cardiac Rhythm Using an Epicardial Electrogram

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