Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma

Abstract

The non-classical human leukocyte antigens (HLA)-E, HLA-G, and HLA-F have been shown to modulate immune responses. We examined whether non-classical HLA polymorphisms are associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Fifteen Single-nucleotide polymorphisms (SNPs) in these non-classical class I alleles were investigated by ligase detection reaction. A fragment of 650 bp located in the 3' untranslated region of HLA-G was investigated. Four SNPs (rs17875380, rs41557518, rs114465251, and rs115492845) were associated with altered susceptibility to HBV or HCC, and HLA-F*01:04, HLA-G*01:05N, and HLA-E*01:01 were associated with hepatitis B or hepatitis B complicated with HCC. Six of 16 designated HLA-E, -G, and -F haplotypes were associated with risk of hepatitis B or HCC. Our study provides healthy reference and detailed analyses of non-classical HLA class Ι polymorphisms that provide insight into immune mechanisms involved in susceptibility to hepatitis B and HCC.

Granulin–Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity

“…HLA-E mRNA was reported to be upregulated in HCC tissues when compared with their adjacent nontumor counterparts (38). Furthermore, HLA-E polymorphism was associated with risk of hepatitis B or HCC (39). However, the role of HLA-E in HCC pathogenesis and the cell populations overexpressing HLA-E has not been elucidated in HCC.…”

HLA‐E allelic genotype correlates with HLA‐E plasma levels and predicts early progression in chronic lymphocytic leukemia

“…Expression levels of HLA‐E *01:03 are generally higher than those of HLA‐E *01:01, which might be attributed to the affinity and thermal stability of peptides bound by HLA‐E *01:03 . It is noteworthy that the latter HLA‐E allele have been associated with transplantation outcomes, the severity of psoriasis, hepatitis C virus infections, and the progression of solid tumors . These HLA‐E alleles are discussed as biomarkers in various diseases, including cancer.…”

HLA‐G gene 14‐bp deletion variant protects Iranian subjects against chronic hepatitis B infection

“…(), organ transplants Moreau, Flajollet, and Carosella (), and in viral infections like hepatitis B Baricordi, Stignani, Melchiorri, and Rizzo (), Zhang et al. (). These studies have indicated that HLA‐G contributes to the virus or tumour cells escape from host immune defences, and suggested that it might serve as a clinical marker for the diagnosis or prediction of the clinical outcomes of these diseases Ye et al.…”