<scp>HLA</scp>‐G gene 14‐bp deletion variant protects Iranian subjects against chronic hepatitis B infection

Eskandari-Nasab, Ebrahim; Dahmardeh, Tayebeh; Safdari, Vahid; Khosravi, Soheila; Pahlevani, Elham

doi:10.1111/iji.12337

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…In the case of chronic hepatitis B infection (CHB), it was reported that the HLA‐G 14‐bp deletion polymorphism was associated with a reduced risk of CHB at both allele and genotypic levels. Thus, the 14‐bp DEL allele and INS/DEL genotype were more frequent in control group than in CHB patients (Eskandari et al, 2017). Yet, not all published results readily support the association between HLA‐G alleles and virus infection susceptibility and several reports (including meta‐analysis) question this linkage (Alves et al., 2015; Lv et al, 2018).…”

Section: Hla‐g and Diseasementioning

confidence: 99%

HLA‐G: Function, polymorphisms and pathology

Arnaiz‐Villena

Juárez

Suárez-Trujillo

et al. 2020

Int J Immunogenetics

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HLA‐G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA‐G function, polymorphism and pathology that have been confirmed by several different researchers, together with exposing aspects that may have been overlooked or not sufficiently remarked in this productive field of study. On the other hand, we question whether performing mainly studies on HLA‐G and disease associations is going to give a clear answer in the future, since 40 years of study of classical HLA molecules association with disease has still given no definite answer on this issue.

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Section: Hla‐g and Diseasementioning

confidence: 99%

HLA‐G: Function, polymorphisms and pathology

Arnaiz‐Villena

Juárez

Suárez-Trujillo

et al. 2020

Int J Immunogenetics

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“…To date, most studies have focused on HLA-G polymorphism and HPV-related diseases in women [21,[23][24][25][26][27][28][29]. The few studies in which male participants were included have mainly focused on exploring HLA-G polymorphism in the HLA-G 3′ untranslated region (UTR) and disclosed an association with other viral infections, such as HCV [30], HBV [31,32], and HIV [33,34]. The data evaluating HLA-G specifically among men is sparse.…”

Section: Discussionmentioning

confidence: 99%

The association of HLA-G polymorphism with oral and genital HPV infection in men

Suominen

Jaakola

Roger

et al. 2021

Eur J Clin Microbiol Infect Dis

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The host genetic factors that influence the natural history of human papillomavirus (HPV) infection in men are not well known. Our aim was to evaluate the role of human leukocyte antigen (HLA)-G polymorphism in oral and genital HPV infection in men. Altogether, 130 men from the Finnish Family HPV Study, with a 6-year follow-up, were included in the analyses. HLA-G alleles were tested by direct sequencing. Oral, urethral, and semen samples were collected and analyzed for 24 different HPV genotypes. Unconditional logistic regression was used to determine associations between HLA-G alleles and genotypes with HPV infection and its outcomes. Overall, eight different HLA-G alleles were identified with 15 different HLA-G genotype combinations. The most common HLA-G allele among the men was G*01:01:01 (86.2%, n = 112) followed by G*01:01:02 (36.2%, n = 47). Allele G*01:01:02 showed to be protective against any- and high-risk (HR) oral HPV (OR range of 0.20–0.24, 95% CI range of 0.06–0.85). Men having allele G*01:01:01 showed a reduced risk for incident (OR 0.30, 95% CI 0.11–0.84) and persistent (OR 0.24, 95% CI 0.08–0.69) oral infections. Allele G*01:01:03 was associated with increased risk for urethral HR-HPV infections (OR 4.94, 95% CI 1.34–18.27). Among self-reported demographic data, genotype G*01:01:01/01:01:03 was associated with an increased risk for oral warts (OR 8.00, 95% CI 1.23–51.89) and allele G*01:03:01 increased the risk of pollen and/or animal allergy (OR 13.59, 95% CI 1.57–117.25). To conclude, HLA-G polymorphism in men largely impacts the outcome of an oral HPV infection and seems to associate with self-reported allergies.

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“…The non-classical HLA and MHC Class I Chain-Related (MIC) genes of the MHC class I region function in both the innate and adaptive immunity and have been targets of candidate gene studies showing putative, though conflicting, roles in diseases. Expression levels and polymorphisms in MICA, MICB, HLA-E and HLA-G have been associated with autoimmune diseases (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), infections (15)(16)(17)(18)(19)(20)(21)(22)(23) and susceptibility to cancer (24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data

Tammi,

Koskela,

Biobank

et al. 2023

Preprint

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In addition to the classical HLA genes, the major histocompatibility complex (MHC) harbors a high number of other polymorphic genes with less established roles in disease associations and transplantation matching. To facilitate studies of the non-classical and non-HLA genes in large patient and biobank cohorts, we trained imputation models for MICA, MICB, HLA-E, HLA-F and HLA-G alleles on genome SNP array data. We show, using both population-specific and multi-population 1000 Genomes references, that the alleles of these genes can be accurately imputed for screening and research purposes. The best imputation model for MICA, MICB, HLA-E, -F and -G achieved a mean accuracy of 99.3% (min, max: 98.6, 99.9). Furthermore, validation of the 1000 Genomes exome short-read sequencing-based allele calling against a clinical-grade reference data showed an average accuracy of 99.8%, testifying for the quality of the 1000 Genomes data as an imputation reference. The imputation models, trained using the HIBAG algorithm, are available at GitHub (https://github.com/FRCBS/HLA_EFG_MICAB_imputation) and can be run locally, thus avoiding the need of sending sensitive genome data to remote portals.

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HLA‐G gene 14‐bp deletion variant protects Iranian subjects against chronic hepatitis B infection

Cited by 6 publications

References 34 publications

HLA‐G: Function, polymorphisms and pathology

HLA‐G: Function, polymorphisms and pathology

The association of HLA-G polymorphism with oral and genital HPV infection in men

Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data

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