Non-Coding RNAs and Endometrial Cancer

Vallone, Cristina; Rigon, Giuliano; Gulìa, Caterina; Baffa, Alberto; Votino, Raffaella; Morosetti, Giulia; Zaami, Simona; Briganti, Vito; Catania, Francesco; Gaffi, Marco; Nucciotti, R.; Costantini, F.M.; Piergentili, Roberto; Putignani, Lorenza; Signore, Fabrizio

doi:10.3390/genes9040187

Cited by 65 publications

(62 citation statements)

References 77 publications

(112 reference statements)

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“…Many papers have investigated the role of ncRNA in EC in an attempt to find new molecular markers able to discriminate the different subtypes, predict prognosis and design new drugs for personalized targeted therapies [ 44 , 45 , 46 , 47 ]. In this review, we focused our attention on more important biological pathways and processes altered in EC and we discussed the role of ncRNAs in their regulation.…”

Section: Ncrnas and Endometrial Cancermentioning

confidence: 99%

Non-Coding RNAs in Endometrial Physiopathology

Ferlita

Battaglia

Andronico

et al. 2018

IJMS

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The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.

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Section: Ncrnas and Endometrial Cancermentioning

confidence: 99%

Non-Coding RNAs in Endometrial Physiopathology

Ferlita

Battaglia

Andronico

et al. 2018

IJMS

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“…Zhou et al [44] experimentally con rmed that large intergenic non-coding ribonucleic acid-RoR is a ceRNA and acts as an miR-145 "sponge" to inhibit the mediation of the differentiation of stem cells by miR-145. Vallone et al [45] reviewed the relationship between non-coding RNAs and oncogenesis (lung cancer, bladder cancer, kidney cancer, and melanoma) based on three years of PubMed records.To date, very few ceRNA network studies have been performed with regards to EC. In the present study, correlation analysis showed that CCNE1 in the MEturquiose module was signi cantly negatively correlated with all of the hub genes in the MEbrown module, while all of the hub genes in the MEbrown module were signi cantly positively correlated, indicating that the two modules are not only modules with respect to topology but also with respect to function, and the existence of two modules is reasonable.…”

Section: Discussionmentioning

confidence: 99%

Construction and Comprehensive Analysis of the Competing Endogenous Rna Network in Endometrial Adenocarcinoma

Feng¹,

Cui²,

Jin³

et al. 2020

Preprint

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Background: Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors. In this study, we constructed gene co-expression networks to identify key modules and hub genes involved in the pathogenesis of EC. Methods: The RNA profiles of adenocarcinoma and non-adenocarcinoma tissues of patients with EC from The Cancer Genome Atlas were analyzed. MicroRNA, mRNA, and long non-coding RNA networks were constructed based on the differentially expressed RNAs between the two tissues. RNAs from the competing endogenous RNA (ceRNA) networks were then used to construct co-expression networks by weighted gene co-expression network analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed by the Database for Annotation, Visualization and Integrated Discovery tool. Results: The MEturquoise module was found to be significantly related to hypertension and the MEbrown module was significantly related to the history of other malignancies. Functional enrichment analysis showed that the MEturquoise module was associated with the GO biological process terms of transcription from RNA polymerase II promoter, positive regulation of male gonad development, endocardial cushion development, and endothelial cell differentiation. The MEbrown module was associated with GO terms DNA binding, epithelial-to-mesenchymal transition, and transcription from RNA polymerase II promoter. A total of 10 hub genes were identified and validated at transcriptional and translational levels. Conclusions: The identified ceRNAs may play a critical role in the progression and metastasis of EC and are thus candidate therapeutic targets and potential prognostic biomarkers. The two modules constructed further provide a useful reference that will advance understanding of the mechanisms of tumorigenesis in EC.

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“…Nevertheless, mounting evidence has emphasized the roles and clinical significance of non-coding RNAs and, in particular lncRNAs, among others in endometrial cancer (33,34).…”

Section: Discussionmentioning

confidence: 99%

Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type�I endometrial cancers

et al. 2018

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Endometrial cancer is the most frequently diagnosed gynecologic malignant disease. Although several genetic alterations have been associated with the increased risk of endometrial cancer, to date, the diagnosis and prognosis still rely on morphological features of the tumor, such as histological type, grading and invasiveness. As molecular-based classification is desirable for optimal treatment and prognosis of these cancers, we explored the potential of lncRNAs as molecular biomarkers. To this end, we first identified by RNA sequencing (RNA-Seq) a set of lncRNAs differentially expressed in cancer vs. normal endometrial tissues, a result confirmed also by analysis of normal and cancerous endometrium RNA-Seq data from TCGA (The Cancer Genome Atlas). A significant association of a subset of these differentially expressed lncRNAs with tumor grade was then determined in 405 TCGA endometrial cancer profiles. Integrating endometrial cancer-specific expression profiles of long and small non-coding RNAs, a functional association network was then identified. These results describe for the first time a functional ῾core᾽ network, comprising small and long RNAs, whose deregulation is associated with endometrial neoplastic transformation, representing a set of cancer biomarkers that can be monitored and targeted for diagnosis, follow-up and therapy of these tumors.

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Non-Coding RNAs and Endometrial Cancer

Cited by 65 publications

References 77 publications

Non-Coding RNAs in Endometrial Physiopathology

Non-Coding RNAs in Endometrial Physiopathology

Construction and Comprehensive Analysis of the Competing Endogenous Rna Network in Endometrial Adenocarcinoma

Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type�I endometrial cancers

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