2024
DOI: 10.3389/ebm.2024.10120
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Non-coding RNAs and neuroinflammation: implications for neurological disorders

Yvonne Chen,
Julia Mateski,
Linda Gerace
et al.

Abstract: Neuroinflammation is considered a balanced inflammatory response important in the intrinsic repair process after injury or infection. Under chronic states of disease, injury, or infection, persistent neuroinflammation results in a heightened presence of cytokines, chemokines, and reactive oxygen species that result in tissue damage. In the CNS, the surrounding microglia normally contain macrophages and other innate immune cells that perform active immune surveillance. The resulting cytokines produced by these … Show more

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Cited by 6 publications
(2 citation statements)
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“…Lee et al, 2004;O'Brien et al, 2018;Shukla et al, 2011). MicroRNAs are seen to participate in the functional regulation at the distant synaptic sites in neuronal cells, and to modulate inflammatory mechanisms that lead to neurological diseases (Chen et al, 2024;Kaurani, 2024).…”
Section: Introductionmentioning
confidence: 99%
“…Lee et al, 2004;O'Brien et al, 2018;Shukla et al, 2011). MicroRNAs are seen to participate in the functional regulation at the distant synaptic sites in neuronal cells, and to modulate inflammatory mechanisms that lead to neurological diseases (Chen et al, 2024;Kaurani, 2024).…”
Section: Introductionmentioning
confidence: 99%
“…They can be expressed within the activation of a gene promoter or their own promoters [1,2], and play a regulatory role in protein synthesis by targeting and degrading RNA transcripts containing compatible nucleotide sequences [3][4][5][6][7]. MicroRNAs are seen to participate in the functional regulation at the distant synaptic sites in neuronal cells, and to modulate inflammatory mechanisms that lead to neurological diseases [8,9].…”
Section: Introductionmentioning
confidence: 99%