Non-coding RNAs regulate autophagy process via influencing the expression of associated protein

Zhao, Yunyi; Wang, Ze; Zhang, Wenhui; Zhang, Linbo

doi:10.1016/j.pbiomolbio.2019.11.009

Cited by 8 publications

(11 citation statements)

References 91 publications

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“…An increasing number of non-coding RNAs are reported to regulate Atg genes [42]. The expression of genes encoding core autophagy-related proteins is regulated by RNA-binding proteins (RBPs) and certain non-coding RNAs, enriching the regulatory mechanisms of autophagy by epigenetics [93].…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs), about 22 nucleotides long, are conserved in evolution and expressed in almost all eukaryotes. Interestingly they have been identified as sequence-specific post-transcriptional regulators of gene expression, including Atg genes [42]. miRNA-101 inhibits autophagy by targeting RAB5A, a member of the RAS oncogene family, and ATG4d, leading to the suppression of tumor formation [43].…”

Section: Regulation Of Autophagy By Non-coding Rnasmentioning

confidence: 99%

“…In mammals, genomic transcription produces a large number of long non-coding RNAs (lncRNA), which can regulate Atg genes expression and thus mediate autophagy occurrence [42]. In mouse, lncRNA NEAT1 directly binds to miR-29b and then upregulates Atg9a expression to activate autophagy; similarly, LncRNAXIST enhances ethanol-induced autophagy by binding to miRNA-29b [8,53].…”

Section: Regulation Of Autophagy By Non-coding Rnasmentioning

confidence: 99%

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Transcriptional and Post-Transcriptional Regulation of Autophagy

Long

Gan

Tettamanti

et al. 2022

Cells

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Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (microRNA, circRNA, and lncRNA) are reported to participate in autophagy regulation. Finally, post-transcriptional modifications, such as RNA methylation, play a key role in controlling autophagy occurrence. In this review, we summarize the progress on autophagy research regarding transcriptional regulation, which will provide the foundations and directions for future studies on this self-eating process.

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Section: Discussionmentioning

confidence: 99%

Section: Regulation Of Autophagy By Non-coding Rnasmentioning

confidence: 99%

Section: Regulation Of Autophagy By Non-coding Rnasmentioning

confidence: 99%

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Transcriptional and Post-Transcriptional Regulation of Autophagy

Long

Gan

Tettamanti

et al. 2022

Cells

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“…It is, therefore, necessary to analyze indepth the specific mechanism of autophagy. Recent studies have shown that noncoding RNA regulates autophagy by affecting the expression of related genes [34]. A class of miRNAs that first appeared in many noncoding RNA studies continues to explore their regulatory pathways in autophagy [29,35].…”

Section: Autophagy-relatedmentioning

confidence: 99%

The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer

Huang

Sun

et al. 2021

Journal of Oncology

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Autophagy is a treatment target for many disorders, including cancer, and its specific role is becoming increasingly well known. In tumors, researchers pay attention to microribonucleic acids (miRNAs) with regulatory effects to develop more effective therapeutic drugs for autophagy and find new therapeutic targets. Various studies have shown that autophagy-related miRNAs play an irreplaceable role in different tumors, such as miR-495, miR-30, and miR-101. These miRNAs are associated with autophagy resistance in gastric cancer, non-small cell lung cancer, and cervical cancer. In recent years, autophagy-related miRNAs have also been reported to play a role in autophagy in urinary system tumors. This article reviews the regulatory effects of autophagy-related miRNAs in kidney, bladder, and prostate cancer and provides new ideas for targeted therapy of the three major tumors of the urinary system.

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“…Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) can also regulate cell autophagy by modulating gene expression [ 120 ]. Fan et.…”

Section: Cellular and Molecular Aspects Of Autophagymentioning

confidence: 99%

Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

Silva

Neves

Santos

et al. 2020

Cancers

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Autophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells—while in some situations, it has a cytoprotective effect that causes chemotherapy resistance, in others, it has a cytotoxic effect in which some compounds induce autophagy-mediated cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer, including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer stem cells has also been discussed.

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Non-coding RNAs regulate autophagy process via influencing the expression of associated protein

Cited by 8 publications

References 91 publications

Transcriptional and Post-Transcriptional Regulation of Autophagy

Transcriptional and Post-Transcriptional Regulation of Autophagy

The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer

Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

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