Non-cognitive symptoms and related conditions in the Alzheimer’s disease: a literature review

Raudino, Francesco

doi:10.1007/s10072-013-1424-7

Cited by 35 publications

(34 citation statements)

References 69 publications

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“…Getting confused about the dates, seasons and time, as well as familiar places is another sign of the disease. Vision may also be affected, and the patients may not be able to read, to judge distances or to distinguish colours and contrasts and olfactory dysfunction has also been reported [41]. Communication problems may also arise: patients may suffer from difficulties when expressing themselves, they may repeat things or they may stop in the middle of a conversation without knowing how to continue.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…As the disease progresses, this cognitive symptoms become even worse, and the patients start having troubles recognizing people nearby, including family members [22,42]. Reduced prevalence of pain can also be an AD symptom [41].…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Furthermore, they rely more and more on other people for everyday activities, like eating, bathing or dressing because they may have problems to perform well physically. They may also be unable to walk properly, due to gait and balance dysfunction [41], or to sit by themselves and incontinence and swallowing problems may also arise [22,42].…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Nevertheless, it is not still clear if depression is really a consequence of AD or a risk factor by itself [43]. Apathy, irritability, agitation, euphoria, disinhibition, delusions and hallucinations are also part of AD symptomatology [41].…”

Section: Inclusion Criteriamentioning

confidence: 99%

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On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Alberdi

Aztiria

Basarab

2016

Artificial Intelligence in Medicine

167

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Section: Inclusion Criteriamentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

See 2 more Smart Citations

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Alberdi

Aztiria

Basarab

2016

Artificial Intelligence in Medicine

167

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“…However, evidence shows the typical lesions of the AD not only in the brain but also in the spinal cord or even outside the Central Nervous System (CNS). Non-cognitive symptoms, mostly motor or psychiatric symptoms, are also recurrent in the AD (1). The retina is a part of the CNS easy to study.…”

Section: Contextmentioning

confidence: 99%

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

Raudino

2018

Arch Neurosci

Self Cite

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Context: The retina is a part of the Central Nervous System that is easy to study. The visual disturbances are frequent in Alzheimer's disease (AD) patients and sometimes, the AD begins with visual symptoms. This paper aims to review the existing literature on the involvement of the eye in the AD. In this first part, the animal models and the pathology in humans were examined. Evidence Acquisition: The Medline literature until March 2018 was surveyed. Results: Both animal models and pathological studies in humans demonstrate the impairment of the visual system in the AD, often in the early stages. Conclusions: A frequent and sometimes early involvement of the visual system was demonstrated but new studies are needed in order to investigate the degree of the visual impairment and in the animal models, the importance of the visual deficits in evaluating the cognitive deficits.

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Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease‐Like Pathology in Transgenic APP/PS1 Mice

Wang

Guan

Chen

et al. 2019

Molecular Nutrition Food Res

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Scope: Alzheimer's disease (AD) is a detrimental neurodegenerative disease and has no known effective treatment. The essential nutrient choline potentially plays an important role in cognition. Perinatal choline supplementation (CS) is critical for memory performance. Findings have shown that postnatal choline-containing compounds enhance memory functions in populations with memory impairments. However, whether CS can be targeted to decelerate the progression of AD remains unknown. Methods and results: APP/PS1 mice and their wild-type littermates are fed either a control or CS diet from 2 to 11 months of age. As compared to WT mice, APP/PS1 mice on the control diet are characterized by the reduction in the number of cholinergic neurons in the basal forebrain, reduced cholinergic fiber staining intensity in the amygdala, and reduced hippocampal and cerebral cortical levels of choline and acetylcholine. CS partially prevents these changes and ameliorates cognitive deficits and anxiety. Furthermore, amyloid-β deposition and microgliosis are decreased in the APP/PS1 mice fed a CS diet. These effects may have been due to inhibition of NLRP3 inflammasome activation and restoration of synapse membrane formation.

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Non-cognitive symptoms and related conditions in the Alzheimer’s disease: a literature review

Cited by 35 publications

References 69 publications

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease‐Like Pathology in Transgenic APP/PS1 Mice

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