Purpose -This applied neuroscience study aims to understand how direct and unconscious emotional and cognitive responses underlie travel destination preferences. State-of-the-art neuroscience tools and methods were used, including stationary eye tracking and brain scanning electroencephalography (EEG) to assess emotional and cognitive responses to destination images and assets. To the researchers' knowledge, this study is the first applied neuroscience study in tourism research and thus opens a new path of research and enquiry to this area. This paper is an attempt to understand specific mental processes in human tourism behaviours, and it is suggest that unconscious emotional and cognitive responses are natural processes that need to be studied and understood, not as special cases, but embedded as natural parts of tourism research.Design/methodology/approach -To better understand consumers' unconscious responses to possible travel destinations, a 3 Â 5 factorial design was run with the factors being stimulus type (images, printed names and videos) and travel destination (Dubai, Abu Dhabi, Hong Kong, New York and London). Eyetracking calibration was done with a nine-point fixation test and the EEG calibration was done using functional localizer tests based on the ABM B-ALERT calibration process. This calibration procedure allows reliable tracking of emotional and cognitive responses over time. Thirty Emirati (nationals of the UAE) participants, consisting of equal numbers of males and females (15) were recruited from the UAE and signed informed consent. Each participant was positioned in front of an eye tracker and computer screen, and brainscanning equipment was mounted; then, each participant underwent eye-tracking and neuroimaging calibration procedures. A Tobii T60XL eye tracker and an ABM X-10 EEG brain scanner, both running iMotions v5.1 in a Windows 7 environment, were used.Findings -General emotional and cognitive differences were identified between the channels through which travel destinations are presented. Words about and names of travel destinations cause higher cognitive