Non-contrast ASL perfusion in preoperative diagnosis of supratentorial gliomas

Баталов, А И; Захарова, Н. Е.; Pogosbekyan, E L; Фадеева, Л. М.; Goryaynov, S A; Baev, A A; Шульц, Е. И.; Chelushkin, D M; Потапов, А А; Pronin, Igor

doi:10.17116/neiro20188206115

Cited by 19 publications

(10 citation statements)

References 30 publications

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“…Most of the studies also discovered significant differences in blood flow between HGG and LGG 24 – 34 . The results of our study agree with Xiao et al 27 , who used a similar approach.…”

Section: Discussionmentioning

confidence: 99%

“…A number of recent studies were devoted to analyzing the role of pCASL-perfusion in differentiating cerebral gliomas grades 4 , 23 – 34 . Some studies found pCASL to be ineffective for glioma differentiation 4 , 23 , while others, on the contrary, claimed its efficacy 24 – 34 . They showed contradictory results regarding sensitivity and specificity, together with a great variety of the reported threshold values.…”

Section: Introductionmentioning

confidence: 99%

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3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

Баталов

Захарова

Pronin

et al. 2022

Sci Rep

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The aim of the study was to evaluate the role of pseudocontinuous arterial spin labeling perfusion (pCASL-perfusion) in preoperative assessment of cerebral glioma grades. The study group consisted of 253 patients, aged 7–78 years with supratentorial gliomas (65 low-grade gliomas (LGG), 188 high-grade gliomas (HGG)). We used 3D pCASL-perfusion for each patient in order to calculate the tumor blood flow (TBF). We obtained maximal tumor blood flow (maxTBF) in small regions of interest (30 ± 10 mm2) and then normalized absolute maximum tumor blood flow (nTBF) to that of the contralateral normal-appearing white matter of the centrum semiovale. MaxTBF and nTBF values significantly differed between HGG and LGG groups (p < 0.001), as well as between patient groups separated by the grades (grade II vs. grade III) (p < 0.001). Moreover, we performed ROC-analysis which demonstrated high sensitivity and specificity in differentiating between HGG and LGG. We found significant differences for maxTBF and nTBF between grade III and IV gliomas, however, ROC-analysis showed low sensitivity and specificity. We did not observe a significant difference in TBF for astrocytomas and oligodendrogliomas. Our study demonstrates that 3D pCASL-perfusion as an effective diagnostic tool for preoperative differentiation of glioma grades.

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“…Most of the studies also discovered significant differences in blood flow between HGG and LGG 24 – 34 . The results of our study agree with Xiao et al 27 , who used a similar approach.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

Баталов

Захарова

Pronin

et al. 2022

Sci Rep

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“…Был проведен ряд исследований, в которых ASL-перфузия применялась для оценки ангиогенеза в глиомах разной степени злокачественности [20][21][22][23][24]. Полученные в нашем исследовании показатели CBF в опухолевой ткани (135,4 ± 41,3) в целом сопоставимы с данными в вышеперечисленных работах, где исследовался кровоток в глиомах высокой степени злокачественности: в исследовании H. Ma и соавт.…”

Section: Discussionunclassified

The potentiality of arterial spins labeling (ASL) magnetic resonance perfusion technique for the diagnosis of glioblastoma residual tissue

Бунак

Степанова

Stashuk

2021

Almanac of Clinical Medicine

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Background: Growing glioblastoma is associated with an impairment of the blood brain barrier and increased hemodynamic parameters (CBV, CBF), which is related to advanced tumor angiogenesis. Arterial spin labeling (ASL) perfusion, an additional study to the routine intravenous contrast-enhanced magnetic resonance imaging (MRI), may be a technique for assessment of hemodynamics and identification of the residual tumor tissue.Aim: To study the potential of native ASL to assess hemodynamic parameters and detect residual tumor tissue in the patients who had undergone surgical resection of glioblastoma.Materials and methods: At 2 to 4 weeks after surgery for glioblastoma grade IV, brain MRI with native ASL perfusion and subsequent intravenous contrast enhancement was performed in 63 patients. Cerebral blood flow (CBF) values were measured in three areas of interest: in the presumptive tumor tissue (PTT) with maximal perfusion, in the postoperative scar tissue (PST) and in the deep white matter (DWM) of the contralateral hemisphere.Results: According to their CBF values, all patients were categorized into two groups. Group 1 included 43 patients (68.3%) with mean CBF in PTT of 135.4±41.3 ml/100 Gr/min (min 73.9, max 255.9). These values were 5 to 6-fold higher than the CBF values in the PST and 6 to 8-fold higher than those in DWM. Group 2 included 20 patients (31.7%) without any areas of abnormal CBF increase in PST, with its mean value of 22.1±5.6 ml/100 Gr/min (min 13.9, max 37.1), which was close to the CBF level in DWM (19.8±4.6 ml/100 Gr/min, p=0.06). There were no between-group differences for the CBF values in PST (p=0.6), and DWM (p=0.7).Conclusion: ASL MR perfusion technique has good potential for the identification of residual tumor tissue after surgical resection of glioblastoma and can be an alternative to contrast enhancement during long-term follow up.

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“…A different approach was adopted for measuring TBF in other studies, including small-sized ROI/VOI. Lin et al (2015) included solid component of the tumor picked on the slice with the highest TBF on the color maps [22]. ROI size was not speci ed in the paper.…”

Section: Discussionmentioning

confidence: 99%

ASL-Perfusion for Intrinsic Brain Tumor Diagnosis. Analysis of 253 Patients.

Баталов

Захарова

Pronin

et al. 2021

Preprint

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Purpose The aim of the study was to evaluate the role of pseudo-continuous ASL-perfusion (pCASL-perfusion) in preoperative assessing of cerebral glioma grades. Methods The study group consisted of 253 patients aged 7 to 78 years with supratentorial gliomas (65 had low-grade gliomas (LGG), 188 – high-grade gliomas (HGG)). Maximal tumor blood flow (maxTBF) in small ROIs (20 mm2 ± 10 mm2) were evaluated by subsequently normalized tumor blood flow (nTBF) calculation which was compared with normal appearing white matter of center semiovale of the contralateral hemisphere. Results TBF and nTBF values were significantly differed in HGG and LGG groups, as well as grade II and grade III gliomas; grade III and grade IV gliomas (p < 0.001). ASL-perfusion has demonstrated both high sensitivity and specificity in differentiating LGG and HGG, grade II and grade III gliomas, but low sensitivity and specificity in distinguishing grade III and grade IV gliomas. We did not observe a significant difference in TBF in astrocytomas and oligodendrogliomas. Conclusion Current results demonstrate that 3D pCASL-perfusion is an effective diagnostic tool for preoperative differentiation of low and high grade gliomas.

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Non-contrast ASL perfusion in preoperative diagnosis of supratentorial gliomas

Cited by 19 publications

References 30 publications

3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

The potentiality of arterial spins labeling (ASL) magnetic resonance perfusion technique for the diagnosis of glioblastoma residual tissue

ASL-Perfusion for Intrinsic Brain Tumor Diagnosis. Analysis of 253 Patients.

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