Non-destructive detection of adulterated tablets of glibenclamide using NIR and solid-phase fluorescence spectroscopy and chemometric methods

Fernandes, Rafael da Silva; Costa, Fernanda S. L.; Valderrama, Patrícia; Março, Paulo Henrique; Lima, Kássio M. G.

doi:10.1016/j.jpba.2012.03.004

Cited by 27 publications

(11 citation statements)

References 17 publications

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“…As mentioned before, classification approaches are widely applied in quality controls of pharmaceuticals, in particular to detect counterfeit drugs, as, for instance, it is reported in da Silva Fernandes et al ( 2012 ), where NIR and fluorescence spectroscopy were combined with different classification methods to distinguish among pure and adulterated tablets. In Storme-Paris et al ( 2010 ), a non-destructive approach is proposed to distinguish genuine tablets from counterfeit or recalled (from the market) medicines.…”

Section: Classificationmentioning

confidence: 99%

Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis

2018

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Spectroscopy is widely used to characterize pharmaceutical products or processes, especially due to its desirable characteristics of being rapid, cheap, non-invasive/non-destructive and applicable both off-line and in-/at-/on-line. Spectroscopic techniques produce profiles containing a high amount of information, which can profitably be exploited through the use of multivariate mathematic and statistic (chemometric) techniques. The present paper aims at providing a brief overview of the different chemometric approaches applicable in the context of spectroscopy-based pharmaceutical analysis, discussing both the unsupervised exploration of the collected data and the possibility of building predictive models for both quantitative (calibration) and qualitative (classification) responses.

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Section: Classificationmentioning

confidence: 99%

Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis

2018

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“…According to ICH recommendations [25], at least five concentrations must be used. In this study, six concentrations were chosen in the ranges of 50-300 µg mL -1 metformine, 1.5-9.0 µg mL -1 pioglitazone and 0.5-3 µg mL -1 glibenclamide respectively.…”

Section: Analytical Methods Validationmentioning

confidence: 99%

“…It stimulates the secretion and enhances the utilization of insulin by appropriate tissues. Different methods have been reported for the analysis of Glibenclamide alone or its combination with other drugs is HPLC [19][20][21][22][23][24], voltametric [25], spectophotometry [25] and LCMS/ MS [26].…”

Section: Introductionmentioning

confidence: 99%

Method Development and Validation of Metformine, Pioglitazone and Glibenclamide in Tablet Dosage Form by using RP-HPLC

Tengli¹

2013

Biochem Anal Biochem

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Reverse phase high performance liquid chromatographic method has developed for the simultaneous estimation of metformine, pioglitazone and glibenclamide in tablet dosage for using gliclazide as an internal standard. The separation was achieved at ambient temperature with low pressure gradient mode by using 5 µ size phenomenex luna CN (100R 250×4.60 (mm) column with mobile phase containing acetonitrile, water and buffer (0.5% potassium dihydrogen phosphate) pH 2.5 adjusted with orthophosphoic acid in the ratio of 60:20:20. The flow rate was 1 mL min -1 and eluent was monitored at 230 nm by using UV detector. The selected chromatographic conditions effectively separated Metformine, pioglitazone and Glibenclamide with the retention time of 2.2, 2.8 and 5.8 min respectively. The linearity range for metformine, pioglitazone and glibenclamide is found in the range of 50-300 µg mL -1 , 1.5-9.0 µg mL -1 and 0.5-3.0 µg mL -1 respectively. The developed method was found to be accurate, simple, specific and reproducible. It can also be used for routine quality control analysis of these antidiabetic drugs in combinational dosage forms.

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“…Hal tersebut dapat mengakibatkan masyarakat Pemana kurang mengetahui pentingnya makanan tradisional daerah karena makanan tradisional adalah sangat berarti bagi setiap tempat [6]. Makanan tradisonal adalah makanan yang unik dan sangat berbeda dengan jenis produk makanan lain.…”

Section: Pendahuluanunclassified

Penerapan Jaringan Saraf Tiruan Untuk Menghitung Nilai Kandungan Makanan

Trisno¹,

Widiyantoro

Robo

2020

JSAI

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Kasoami merupakan makanan khas tradisional dari Desa Pemana. Makanan ini berasal dari ubi kayu lalu diproses dalam pengukusan. masyarakat yang mengkonsumsi makanan tersebut kurang mengetahui adanya nilai-nilai kandungan makanan. Dengan itu di terapkannya suatu apikasi yang dinamakan Aplikasi MENIKAM. Aplikasi MENIKAM ini singkatan dari Menghitung Nilai Kandungan Makanan yang bertujuan untuk membantu masyarakat dalam mengetahui nilai kandungan makanan. Pengembangan Aplikasi MENIKAM merupakan aplikasi cerdas yang dapat membantu mengetahui nilai kandungan makanan yang dikembangkan dengan metode NIR dan Kalibrasi Jaringan Saraf Tiruan. Selain untuk menghitung nilai kandungan makanan Aplikasi MENIKAM juga dapat memberikan sebuah tutorial proses pembuatan makanan dan menyediakan salah satu form untuk penjualan makanan. Untuk hasil yang di dapatkan yaitu menentukan komposisi utama ubi kayu di ambil dua puluh sampel Ubi (biji utuh) dipindai Panjang dari 20-30 cm. Model kalibrasi untuk pengukuran NIR menggunakan Jaringan Syaraf Tiruan (JST) tiga lapisan teknik. Sebagai lapisan input JST adalah input pertama 5, kedua 10, dan 15 komponen utama (PC). Outputnya adalah komposisi simultan yang akan di prediksi. Kontribusi dari aplikasi MENIKAM ini adalah memprediksi nilai kandungan makanan yang belum masyarakat ketahui dalam mengkonsumsi dengan bantuan metode-metode yang ada

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Non-destructive detection of adulterated tablets of glibenclamide using NIR and solid-phase fluorescence spectroscopy and chemometric methods

Cited by 27 publications

References 17 publications

Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis

Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis

Method Development and Validation of Metformine, Pioglitazone and Glibenclamide in Tablet Dosage Form by using RP-HPLC

Penerapan Jaringan Saraf Tiruan Untuk Menghitung Nilai Kandungan Makanan

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